Results 121 to 130 of about 13,194,872 (182)

Production, purification and kinetic characterization of glutaminase free anti-leukemic L-asparaginase with low endotoxin level from novel soil isolate

, 2019
Anti-leukemic enzyme L-asparaginase despite having significant applicability in medicine, holds side effects attributed to glutaminase activity and endotoxin content. Glutaminase activity proves to be toxic to non-tumor cells as glutamine is an essential
Hare Ram Singh (8013341), Pragya Prakash (8013338), Santosh Kumar Jha (1373979)   +2 more
core   +1 more source

Tissue trans-glutaminase antibody in Inflammatory Bowel Disease in Golestan province, Northern Iran (2005-08)

مجله دانشگاه علوم پزشکی گرگان, 2011
Background and Objective: Celiac is a hereditary disease presented with chronic inflammation of small intestine. Several studies supposed a relationship between Celiac disease and Inflammatory Bowel Disease (IBD). Tissue trans-glutaminase antibody is one
Amiriani T, Besharat S, Semnani Sh, Joshaghani HR, Roshandel GhR, Keshtkar AA, Kiaii MR, Mirkarimi HS, Hashemi-Nasab SZ, Zendeh-Bad AS   +9 more
doaj  

Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines

, 2015
L-Asparaginase (ASNase) is a front-line chemotherapy for acute lymphoblastic leukemia (ALL), which acts by deaminating asparagine and glutamine. To evaluate the importance of glutaminase activity, we exploited a recently developed mutant of Helicobacter ...
Erika Tarasco, Maristella Maggi, Steven D. Mittelman, Avramis, Vassilios I., Mittelman, Steven D., Vassilios I. Avramis, Claudia Scotti, Parmentier, Jean Hugues, MAGGI, MARISTELLA, Jean Hugues Parmentier, SCOTTI, CLAUDIA, Tarasco, Erika   +11 more
core   +1 more source

Kinetics of Soil L-Glutaminase Enzyme

International Journal of Current Microbiology and Applied Sciences, 2017
G . Pavani, P. Chandrasekhar Rao, G. Padmaja, R. Subhash Reddy   +3 more
openaire   +1 more source

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo

, 2018
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug L-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL cells.
Caffrey, Michael, Liu, Li, Van Vlierberghe, Pieter, Saunthararajah, Yogen, Kasim K. Kabirov, Mondelaers, Veerle, Lammens, Tim, Schlicht, Michael J, Bradley J. Merrill, Bosland, Maarten C, Michael Caffrey, Antanasijevic, Aleksandar, Andre Kajdacsy-Balla, Peirs, Sofie, Damiano Rondelli, Zhang, Jenny Yu, Maarten C. Bosland, Jenny Y. Zhang, Barbara De Moerloose, Michael J. Schlicht, Kabirov, Kasim K, Hien Anh Nguyen, Annie Oh, Lyubimov, Alexander V, Oh, Annie, Veerle Mondelaers, Mahmud, Dolores L, Steven Goossens, Amanda M. Schalk, Su, Ying, Rondelli, Damiano, Tim Lammens, Yogen Saunthararajah, Arnon Lavie, Ying Su, Schalk, Amanda M, Pieter Van Vlierberghe, De Moerloose, Barbara, Alexander V. Lyubimov, Aleksandar Antanasijevic, Li Liu, Goossens, Steven, Lavie, Arnon, Dolores L. Mahmud, Merrill, Bradley J, Nguyen, Hien Anh, Kajdacsy-Balla, Andre, Sofie Peirs   +47 more
core   +1 more source

Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors [PDF]

The Warburg effect is a metabolic alteration in cancer cells characterized by aerobic glycolysis and lactate production. A recent phenotypic screen for compounds that reverse Warburg metabolism identified two compounds, X1 and X4, that restore the ...
Morgan, Miele, Ranjini, Iyengar, Sainabou, Jallow, Scott, Ulrich, Clea, Crane, Noah, Strathmann   +5 more
core   +1 more source

Optimum conditions for L-glutaminase production by actinomycete strain isolated from estuarine fish, Chanos chanos (Forskal, 1775)

, 2006
256-258Actinomycetes were isolated from skin, gills and gut contents of estuarine fish, Chanos chanos using Kuster’s agar medium. Out of 20 strains tested, the strain LG-10 which was tentatively identified as Streptomyces rimosus showed L-glutaminase
Sahu, Maloy Kumar, Sivakumar, K, Manivel, P R, Kannan, L   +3 more
core  

Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2-Deficient Mouse Model

Cells
Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by mutations in the MeCP2 gene, predominantly affecting females. Recent work with MeCP2-deficient mouse models showed a significant role in glutamatergic transmission, specifically ...
Preeti Vyas, Elizabeth Smith Khoury, Nirnath Sah, Anjali Sharma, Javier Allende Labastida, Elizabeth L. Wilkinson, Kathleen Lac, Nerketa N. L. Damiba, Amanda Fowler, Jinhuan Liu, Ashley Bedner, Pavel Majer, Tomás Tichý, Ajit G. Thomas, Rana Rais, Barbara S. Slusher, Rangaramanujam M. Kannan, Sujatha Kannan   +17 more
doaj   +1 more source

Enzymatic properties of a L-asparaginase without secondary glutaminase activity from Streptomyces scabrisporus.

PLoS ONE
Acute lymphocytic leukemia (ALL) is characterized by the uncontrolled proliferation of lymphocyte precursor cells within the bone marrow, blood and extramedullary sites. L-asparaginase has become a standard treatment in childhood cases of ALL by reducing
Ricardo Rodríguez-Vargas, Francisca Villanueva-Flores, María Fernanda Gutiérrez-Chávez, Carlos Medrano-Villagómez, Andrés Zárate-Romero, Alejandro Huerta-Saquero   +5 more
doaj   +1 more source

Marine Bacteria Producing L-Asparaginase with Low Glutaminase and Urease Co-Activity from Pangandaran East Coast Indonesia

Squalen
acterial L-asparaginase is a therapeutic enzyme widely used in the treatment of Acute Lymphoblastic Leukemia (ALL). Although L-asparaginase is prominent in treating ALL, its use is limited due to its side effects caused by its dual substrate specificity ...
Wulan Pertiwi, Azmy Jasmine Namira, Maelita Ramdani Moeis, Luthfia Hastiani Muharram, Nelis Hernahadini   +4 more
doaj   +1 more source