Results 121 to 130 of about 312,266 (316)

Oxidation of D-lactate and L-lactate by Neisseria meningitidis: purification and cloning of meningococcal D-lactate dehydrogenase [PDF]

, 1993
Alice L. Erwin, E C Gotschlich
openalex   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug docking

Frontiers in Molecular Biosciences
BackgroundDiabetic foot ulcers are the most common and serious complication of diabetes mellitus, the high morbidity, mortality, and disability of which greatly diminish the quality of life of patients and impose a heavy socioeconomic burden. Thus, it is
Hui Guo, Kui Xiao, Yanhua Zheng, Jianchun Zong   +3 more
doaj   +1 more source

L-Lactate Dehydrogenase A Chain

Definitions, 2020

semanticscholar   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

Some Lactobacillus l -Lactate Dehydrogenases Exhibit Comparable Catalytic Activities for Pyruvate and Oxaloacetate [PDF]

, 2001
Kazuhito Arai, Takeo Kamata, H. Uchikoba, Shinya Fushinobu, Hiroshi Matsuzawa, Hayao Taguchi   +5 more
openalex   +1 more source

Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver

Advanced Science, EarlyView.
The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li, Tongwei Zhang, Tongxiang Tao, Yaxuan Liu, Haining Xia, Sajid ur Rehman, Zeyong Guo, Jing Zhang, Ruiguo Chen, Zhan Zhang, Junfeng Wang, Kun Ma   +11 more
wiley   +1 more source

The catalytic role of tyrosine 254 in flavocytochrome b₂ (l‐lactate dehydrogenase from baker's yeast) [PDF]

, 2001
Muriel Gondry, Joëlle Dubois, Micheline Terrier, Florence Lederer   +3 more
openalex   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Astrocytic pyruvate dehydrogenase kinase-lactic acid axis involvement in glia-neuron crosstalk contributes to morphine-induced hyperalgesia in mice

Fundamental Research
The activation of spinal astrocytes accounts for opioid-induced hyperalgesia (OIH), but the underlying mechanisms remain elusive. The presence of astrocyte-neuron lactate shuttle (ANLS) makes astrocytes necessary for some neural function and ...
Xiaqing Ma, Qi Qi, Wenying Wang, Min Huang, Haiyan Wang, Limin Luo, Xiaotao Xu, Tifei Yuan, Haibo Shi, Wei Jiang, Tao Xu   +10 more
doaj