Results 141 to 150 of about 312,266 (316)

Rationally re-designed mutation of NAD-independent l-lactate dehydrogenase: high optical resolution of racemic mandelic acid by the engineered Escherichia coli [PDF]

, 2012
Tianyi Jiang, Chao Gao, Peipei Dou, Cuiqing Ma, Jian Kong, Ping Xu   +5 more
openalex   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Risk stratification for Splenic Marginal Zone Lymphoma based on haemoglobin concentration, platelet count, high lactate dehydrogenase level and extrahilar lymphadenopathy: development and validation on 593 cases [PDF]

, 2012
Carlos Montalbán, Víctor Abraira, Luca Arcaini, Eva Domingo‐Domènech, Pablo Guisado‐Vasco, Emilio Iannito, Manuela Mollejo, Estella Matutes, Andrés J.M. Ferreri, Antonio Salar, Sara Rattotti, Andrea Carpaneto, Ricardo Pérez Fernández, José Belló, Miguel‐Teodoro Hernández, Dolores Caballero, Félix Carbonell, Miguel Á. Piris   +17 more
openalex   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Activities of Pyruvate Dehydrogenase Complex, Pyruvate Carboxylase and L-Lactate Dehydrogenase in the Liver of Thiamine-deficient Rats

, 1973
Takako Kishibe, Tetsuko Kujime, Osamu Okinaka   +2 more
openalex   +2 more sources

A Real‐Time Cell Death Self‐Reporting Theranostic Agent for Dynamic Optimization of Photodynamic Therapy

Advanced Science, EarlyView.
A cell death self‐reporting photodynamic theranostic nanoagent (CDPN) is developed that integrates photodynamic therapy (PDT) with real‐time K⁺ imaging to provide timely feedback on treatment responses. This approach enables the optimization of the drug‐light interval (DLI), a critical factor in PDT, resulting in significantly enhanced antitumor ...
Wei Bian, Qiyue Wang, Cui He, Pan Tao, Juanjuan Zheng, Yulu Zhang, Jing Li, Fangyuan Li, Hongyan Jia, Daishun Ling   +9 more
wiley   +1 more source

Fructose 1,6-diphosphate-activated L-lactate dehydrogenase from Streptococcus lactis: kinetic properties and factors affecting activation

Journal of Bacteriology, 1977
V. Crow, G. G. Pritchard
semanticscholar   +1 more source

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

Advanced Science, EarlyView.
This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei   +11 more
wiley   +1 more source

Contributory roles of two l-lactate dehydrogenases for l-lactic acid production in thermotolerant Bacillus coagulans [PDF]

, 2016
Lifan Sun, Caili Zhang, Pengcheng Lyu, Yanping Wang, Limin Wang, Bo Yu   +5 more
openalex   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source