Results 81 to 90 of about 312,266 (316)

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Ameliorative effect of L‐carnitine on chronic lead‐induced reproductive toxicity in male rats

Veterinary Medicine and Science, 2021
Lead toxicity is one of the causative agents of male infertility that raised concern from environmental contamination worldwide. L‐carnitine, a biologically active amino acid, present in high concentration in the reproductive organs such as the ...
Rania A. Abdel‐Emam, Esraa A. Ahmed
doaj   +1 more source

Affinity labelling of the allosteric site of the L-lactate dehydrogenase of Lactobacillus casei [PDF]

European Journal of Biochemistry, 1983
Kinetic investigations employing the substrate analogues 2-oxoglutarate and phospho(enol)pyruvate indicate that the allosteric L-lactate dehydrogenase (EC 1.1.1.27) of Lactobacillus casei has a non-catalytic pyruvate-binding site to which, in addition to pyruvate, the allosteric effector fructose 1,6-bisphosphate can also be found. A modification using
Christoph Woenckhaus, Ulrich Dr Rer Nat Mayr, Reinhard Hensel   +2 more
openaire   +3 more sources

Microstructure, Mechanical Properties, and Antibacterial Performance of Novel Fe‐Mn‐Zn Nanocrystalline Alloys Produced by Mechanical Alloying

Advanced Engineering Materials, EarlyView.
This article presents the development of Fe‐Mn‐Zn nanocrystalline alloys (0–9 wt% Zn) by mechanical alloying and subsequently hot pressing. Their microstructure, density, hardness, wear resistance, corrosion behavior, and antibacterial properties are systematically examined.
Ilker Emin Dag, Funda Kilic, Mrutyunjay Panigrahi, Baris Avar   +3 more
wiley   +1 more source

Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

Cancer & Metabolism, 2021
Background Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate.
Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis, A. Dean Sherry   +6 more
doaj   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Molecular Characterization and Enological Potential of A High Lactic Acid-Producing Lachancea thermotolerans Vineyard Strain

Foods, 2020
Lactic acid production is an important feature of the yeast Lachancea thermotolerans that has gained increasing interest in winemaking. In particular, in light of climate change, the biological acidification and ethanol reduction by the use of selected ...
Georgios Sgouros, Athanasios Mallouchos, Maria-Evangelia Filippousi, Georgios Banilas, Aspasia Nisiotou   +4 more
doaj   +1 more source

Ultra‐Effective Light‐Activated Antibacterial Activity via Carboxyl Functionalized Graphene Quantum Dots and Films

Advanced Functional Materials, EarlyView.
Carboxyl‐functionalized graphene quantum dots (cGQDs) exhibit high singlet oxygen quantum yield due to strong spin–orbit coupling. cGQDs achieve minimum bactericidal concentration of only 0.4 µg mL−1 against S. aureus under low‐intensity illumination.
Muhammad Hassnain, Laure S. van Hofwegen, Humeyra Nur Kaleli, Temirlan Kubanaliev, Zafer Eroglu, Asim Onal, Payal P. S. Balraadjsing, Onder Metin, Fahri Alkan, Sebastian A. J. Zaat, Sedat Nizamoglu   +10 more
wiley   +1 more source

In vitro antihistamine-releasing activity of a peptide derived from wasp venom of Vespa orientalis

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To investigate the antihistamine-releasing effect of a peptide isolated from wasp venom of Vespa orientalis. Methods: This peptide was separated from crude venom by chromatography methods and mass spectrometry.
Jafar Jalaei, Mehdi Fazeli, Hamid Rajaian, Somayeh Layeghi Ghalehsoukhteh, Alireza Dehghani, Dominic Winter   +5 more
doaj   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source