Results 171 to 180 of about 729,292 (310)

Renoprotective effects of compound 21 and empagliflozin in L-Name-induced hypertensive rats. [PDF]

BMC Urol
Ozhan O, Colak M, Karaca E, Dogru F, Kucukakcali Z, Acet A, Parlakpinar H.   +6 more
europepmc   +1 more source

Drying temperature affects the hypolipidemic, antioxidant, and antihypertensive potential of Hibiscus sabdariffa calyx in rats induced with L-NAME. [PDF]

Toxicol Rep, 2023
Efosa JO, Omage K, Azeke MA.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hydrolyzed Collagen from Salmon Skin Mitigates L-NAME-Induced Hypertension in Rats by Attenuating Oxidative Stress and Inflammation and Improving Vascular Remodeling. [PDF]

Int J Mol Sci
Mungmuang P, Tocharus J, Panthiya L, Sungnoon R, Nilsuwan K, Benjakul S, Tocharus C.   +6 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

UNI-494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L-NAME and angiotensin II. [PDF]

Physiol Rep
Ho FJM, Siow CJR, Aljaibeji H, Ding M, Mitchell RN, Medicherla S, Reddy G, Gupta S, Williams GH, Romero JR.   +9 more
europepmc   +1 more source

Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats. [PDF]

Cardiovasc Ther, 2023
Razzaq MA, Younis W, Malik MNH, Alsahli TG, Alamgeer, Jahan S, Ehsan R, Gasparotto Junior A, Bashir A.   +8 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Renoprotective effect of dulaglutide in L-NAME-induced hypertensive nephropathy in rats: insight into the roles of PPAR-gamma and VEGF. [PDF]

Hypertens Res
Bastawy N, El-Mosallamy AEMK, Rasheed RA, Sadek AS, Khattab RT, Ali E, Zaghloul RA, Ghaly WBA, Boushra AF.   +8 more
europepmc   +1 more source

Antihypertensive effect of the stem bark aqueous extract of Garcinia lucida Vesque (Clusiaceae) in L-NAME-treated rats: Contribution of endothelium-dependent and -independent vasorelaxation. [PDF]

Heliyon, 2023
Nguelefack-Mbuyo EP, Sonfack CS, Fofié CK, Fodem C, Ndjenda Ii MK, Dongmo AB, Nguelefack TB.   +6 more
europepmc   +1 more source