Results 21 to 30 of about 714,437 (290)

The L-NAME effects in acute experimental peritonitis

Science and Innovations, 2022
The article presents the results of research to study the course of experimental peritonitis in rats under administration of non-selective NO-synthase inhibitor, Nώ-nitro-L-arginine methyl ester (L-NAME). It has been shown that administration of L-NAME results in increase in the severity of in-toxication, reaction of leukocytes of blood and peritoneal ...
E. Gusakovskaya, N. Maksimovich
openaire   +1 more source

Cardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone [PDF]

, 2014
Background: Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload.
Coelho‐Filho, Otavio R., Jerosch‐Herold, Michael, Kwong, Raymond, Mitchell, Richard, Moreno, Heitor, Neilan, Tomas G., Shah, Ravi V.   +6 more
core   +1 more source

Hesperidin, a citrus flavonoid, protects against l-methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats

Pharmaceutical Biology, 2017
Context: Hesperidin (HSP), a flavanoglycone found in citrus fruits, has antioxidant, anti-inflammatory and neuroprotective properties. Objective: This study evaluates the protective effect of HSP on l-methionine-induced hyperhomocysteinemia (HHcy) in ...
B. Hemanth Kumar, B. Dinesh Kumar, Prakash V. Diwan   +2 more
doaj   +1 more source

The development of hypertensive neuroretinopathy model on wistar rats [PDF]

, 2017
A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on the background of single increased ...
Dolzhikov, A. A., Gubareva, V. O., Levkova, E. A., Peresypkina, A. A., Shabelnikova, A. S.   +4 more
core   +2 more sources

Aliskiren and valsartan in combination is a promising therapy for hypertensive renal injury in rats

Clinical and Experimental Hypertension, 2018
Neither ACEI nor ARBs completely repress the RAAS. Aliskiren is a newer agent that inhibits renin. However, it increases the biosynthesis and secretion of renin and prorenin, that might induce renal tissue damage.
Hala Salah Abdel Kawy
doaj   +1 more source

L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats

Brazilian Journal of Pharmaceutical Sciences, 2012
Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation mediated by the P450 enzyme system.
Natália Valadares de Moraes, Mateus Machado Bergamaschi, Maria de Lourdes Pires Bianchi, Juliana Bordinassi Bragheto, Wilson Roberto Malfará, Regina Helena Costa Queiroz   +5 more
doaj   +1 more source

The Effects of L-NAME and Agmatine in The Nucleus Accumbens Core Regıon on Morphine Withdrawal Syndrome

Namık Kemal Tıp Dergisi, 2020
Aim:The mesocorticolimbic dopaminergic system, especially the nucleus accumbens, is an important region in opioid dependence and withdrawal. Studies have shown that nitric oxide synthase inhibitors modulate the development of tolerance to opioids, opioid
Mahluga JAFAROVA DEMİRKAPU, Hasan Raci YANANLI, Elmar MAMMADOV, Ina DERVİSHİ, Ali KIRBAŞ, Şafak Recep YAŞAR, Tzemal SALİ, Mansur KURBANOĞLU, Merve ÇAĞLAR, Öykü USLU, Halil Eren SAKALLİ, Betilay TOPKARA   +11 more
doaj   +1 more source

Increasing the fungicidal action of Amphotericin B by inhibiting the Nitric Oxide-Dependent tolerance pathway [PDF]

, 2017
Amphotericin B (AmB) induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear.
Cammue, Bruno P. A., Cools, Tanne L., Kokalj, Tadej, Kumar, Phalguni Tewari, Lammertyn, Jeroen, Ludovico, Paula, Marques, Belém Sampaio, Spincemaille, Pieter, Struyfs, Caroline, Thevissen, Karin, Vriens,Kim   +10 more
core   +3 more sources

Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System—Triple NO-Agent Approach in Rats

Pharmaceuticals
Background/Objectives: This 7-day rat tracheocutaneous fistula study considered the not-studied issues of tracheocutaneous fistula course, wound healing, and fistula in the NO-system relations.
Goran Madzarac, Tomislav Becejac, Toni Penovic, Dominik Drazenovic, Lucija Kralj, Marta Popović Dolic, Suncana Sikiric, Lidija Beketic Oreskovic, Ivana Oreskovic, Sanja Strbe, Ana Maria Tubikanec, Mihovil Penavic, Hrvoje Vranes, Ivan Krezic, Mario Kordic, Antun Koprivanac, Tinka Vidovic, Josipa Vlainic, Dinko Stancic Rokotov, Alenka Boban Blagaic, Sven Seiwerth, Anita Skrtic, Predrag Sikiric   +22 more
doaj   +1 more source

Effect of Hydroalcoholic Extract of Ribes khorasanicum on Acute Hypertension Induced by L-NAME in Rat

Journal of Pharmacopuncture, 2019
Objectives: The aim of this study was to evaluate the effect of Ribes khorasanicum (R. khorasanicum); a plant growing in north Khorasan of Iran; on cardiovascular and stress oxidative in acute hypertension induced by N-nitro-l-arginine methyl ester (L ...
Ismael Hamounpeima, Mahmoud Hosseini, Reza Mohebbati, Mohammad Naser Shafei   +3 more
doaj   +1 more source