Results 31 to 40 of about 713,418 (262)

Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension [PDF]

Frontiers in Medicine, 2020
Hypertension-induced renal injury is characterized by structural kidney alterations and function deterioration. Therapeutics for kidney protection are limited, thus novel renoprotectives in hypertension are being continuously sought out. Ivabradine, an inhibitor of the If current in the sinoatrial node reducing heart rate (HR), was shown to be of ...
Peter Stanko, Tomas Baka, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Andrej Barta, Pavol Janega, Pavol Janega, Michaela Adamcova, Ludovit Paulis, Ludovit Paulis, Fedor Simko, Fedor Simko, Fedor Simko   +13 more
openaire   +3 more sources

Aliskiren and valsartan in combination is a promising therapy for hypertensive renal injury in rats

Clinical and Experimental Hypertension, 2018
Neither ACEI nor ARBs completely repress the RAAS. Aliskiren is a newer agent that inhibits renin. However, it increases the biosynthesis and secretion of renin and prorenin, that might induce renal tissue damage.
Hala Salah Abdel Kawy
doaj   +1 more source

The Effects of L-NAME and Agmatine in The Nucleus Accumbens Core Regıon on Morphine Withdrawal Syndrome

Namık Kemal Tıp Dergisi, 2020
Aim:The mesocorticolimbic dopaminergic system, especially the nucleus accumbens, is an important region in opioid dependence and withdrawal. Studies have shown that nitric oxide synthase inhibitors modulate the development of tolerance to opioids, opioid
Mahluga JAFAROVA DEMİRKAPU, Hasan Raci YANANLI, Elmar MAMMADOV, Ina DERVİSHİ, Ali KIRBAŞ, Şafak Recep YAŞAR, Tzemal SALİ, Mansur KURBANOĞLU, Merve ÇAĞLAR, Öykü USLU, Halil Eren SAKALLİ, Betilay TOPKARA   +11 more
doaj   +1 more source

Effect of Hydroalcoholic Extract of Ribes khorasanicum on Acute Hypertension Induced by L-NAME in Rat

Journal of Pharmacopuncture, 2019
Objectives: The aim of this study was to evaluate the effect of Ribes khorasanicum (R. khorasanicum); a plant growing in north Khorasan of Iran; on cardiovascular and stress oxidative in acute hypertension induced by N-nitro-l-arginine methyl ester (L ...
Ismael Hamounpeima, Mahmoud Hosseini, Reza Mohebbati, Mohammad Naser Shafei   +3 more
doaj   +1 more source

The effect of L-NAME on intra- and inter-nephron synchronization

European Journal of Pharmaceutical Sciences, 2009
Kidney autoregulation involves complicated intra- and inter-nephron synchronization phenomena among oscillatory modes produced, respectively, by the tubuloglomerular feedback (TGF) mechanism and by the myogenic regulation of the afferent arteriolar blood flow.
Sosnovtseva, O V, Pavlov, A N, Pavlova, O N, Mosekilde, E, Holstein-Rathlou, Niels-Henrik   +4 more
openaire   +3 more sources

Experimental preeclampsia development depends on vitamin D(3) status in female wistar rats [PDF]

The Ukrainian Biochemical Journal
Deficiency of vitamin D3 during pregnancy is a widespread challenge associated with increased risk of complications, particularly preeclampsia (PE), a serious condition characterized by hypertension with proteinuria.
I. V. Poladych, I. O. Shymanskyi, M. M. Veliky, D. O. Govsieiev   +3 more
doaj   +1 more source

Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System—Triple NO-Agent Approach in Rats

Pharmaceuticals
Background/Objectives: This 7-day rat tracheocutaneous fistula study considered the not-studied issues of tracheocutaneous fistula course, wound healing, and fistula in the NO-system relations.
Goran Madzarac, Tomislav Becejac, Toni Penovic, Dominik Drazenovic, Lucija Kralj, Marta Popović Dolic, Suncana Sikiric, Lidija Beketic Oreskovic, Ivana Oreskovic, Sanja Strbe, Ana Maria Tubikanec, Mihovil Penavic, Hrvoje Vranes, Ivan Krezic, Mario Kordic, Antun Koprivanac, Tinka Vidovic, Josipa Vlainic, Dinko Stancic Rokotov, Alenka Boban Blagaic, Sven Seiwerth, Anita Skrtic, Predrag Sikiric   +22 more
doaj   +1 more source

Differential responses of mesenteric arterial bed to vasoactive substances in L-NAME-induced preeclampsia: Role of oxidative stress and endothelial dysfunction

Clinical and Experimental Hypertension, 2018
To investigate the systemic and placental oxidant status as well as vascular function in experimental preeclampsia (PE) induced by nitro-L-arginine methyl ester (L-NAME). Fetal parameters and maternal blood pressure, proteinuria, mesenteric arterial bed (
Taline A. S. Amaral, Dayane T. Ognibene, Lenize C. R. M. Carvalho, Ana Paula M. Rocha, Cristiane A. Costa, Roberto S. Moura, Angela C. Resende   +6 more
doaj   +1 more source

Role of cilnidipine on quantification of apoptotic cells in the brain of N-nitro-L-Arginine Methyl Ester (L-NAME) induced hypertensive rats

BLDE University Journal of Health Sciences, 2020
Background: Hypertension can lead to myocardial infarction, stroke, renal failure, and death if not detected and treated appropriately. It has also been shown that modulation of nitric oxide (NO) availability is an important determinant of ischemic ...
Surekha B Hippargi, Gouher B Shaikh, Kusal K Das, R M Potekar   +3 more
doaj   +1 more source

Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice

Journal of Pharmacological Sciences, 2005
The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral N(G)-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the alpha- and beta-chains of fibrinogen, whereas plasma
Takinishi, Yasutaka, Okazaki, Masako, Oguchi, Katsuji   +2 more
openaire   +4 more sources