Results 21 to 30 of about 729,292 (310)
Biology Open, 2021 The contractions of Chelonoidis carbonaria aortic rings induced by electrical field stimulation (EFS) are not inhibited by blockade of the voltage-gated sodium channels by tetrodotoxin but almost abolished by the α1/α2-adrenoceptor antagonist ...
José Britto-Júnior +10 more
doaj +1 more source
Involvement of Nitric Oxide in Microcirculatory Reactions after Ischemia-Reperfusion of the Rat Urinary Bladder [PDF]
, 2009 Background: Nitric oxide ( NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM).
Bajory, Z. +4 more
core +2 more sources
The L-NAME effects in acute experimental peritonitis
Science and Innovations, 2022 The article presents the results of research to study the course of experimental peritonitis in rats under administration of non-selective NO-synthase inhibitor, Nώ-nitro-L-arginine methyl ester (L-NAME). It has been shown that administration of L-NAME results in increase in the severity of in-toxication, reaction of leukocytes of blood and peritoneal ...
E. Gusakovskaya, N. Maksimovich
openaire +1 more source
Nitric oxide modulation of glutamatergic, baroreflex, and cardiopulmonary transmission in the nucleus of the solitary tract [PDF]
, 2005 The neuromodulatory effect of NO on glutamatergic transmission has been studied in several brain areas. Our previous single-cell studies suggested that NO facilitates glutamatergic transmission in the nucleus of the solitary tract (NTS).
Colombari, Eduardo +3 more
core +2 more sources
Pharmaceutical Biology, 2017 Context: Hesperidin (HSP), a flavanoglycone found in citrus fruits, has antioxidant, anti-inflammatory and neuroprotective properties. Objective: This study evaluates the protective effect of HSP on l-methionine-induced hyperhomocysteinemia (HHcy) in ...
B. Hemanth Kumar +2 more
doaj +1 more source
Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME [PDF]
, 2017 AIM: To counteract/reveal celecoxib-induced toxicity and NO system involvement. ----- METHODS: Celecoxib (1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157 (known to inhibit these lesions, 10 μg/kg, 10 ng ...
Bauk, Lara +9 more
core +1 more source
Aliskiren and valsartan in combination is a promising therapy for hypertensive renal injury in rats
Clinical and Experimental Hypertension, 2018 Neither ACEI nor ARBs completely repress the RAAS. Aliskiren is a newer agent that inhibits renin. However, it increases the biosynthesis and secretion of renin and prorenin, that might induce renal tissue damage.
Hala Salah Abdel Kawy
doaj +1 more source
Namık Kemal Tıp Dergisi, 2020 Aim:The mesocorticolimbic dopaminergic system, especially the nucleus accumbens, is an important region in opioid dependence and withdrawal. Studies have shown that nitric oxide synthase inhibitors modulate the development of tolerance to opioids, opioid
Mahluga JAFAROVA DEMİRKAPU +11 more
doaj +1 more source
The development of hypertensive neuroretinopathy model on wistar rats [PDF]
, 2017 A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on the background of single increased ...
Dolzhikov, A. A. +4 more
core +2 more sources
Journal of Pharmacopuncture, 2019 Objectives: The aim of this study was to evaluate the effect of Ribes khorasanicum (R. khorasanicum); a plant growing in north Khorasan of Iran; on cardiovascular and stress oxidative in acute hypertension induced by N-nitro-l-arginine methyl ester (L ...
Ismael Hamounpeima +3 more
doaj +1 more source