Results 1 to 10 of about 713,418 (262)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Systemic Nitric Oxide Synthase Inhibition Suppresses Apelin-Induced Rise in Body Temperature in Rats

Acta Medica Bulgarica
Apelin is a peptide involved in the regulation of various physiological processes, including thermoregulation, metabolism, and energy balance. This study investigates the role of nitric oxide (NO) in mediating apelin’s effects on body temperature, food ...
Hristov M., Andreeva-Gateva P.
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Mechanisms of gastroprotective effects of Anabasis articulata (Forssk.) Moq. decoction against ethanol-induced gastric mucosal injury in rats [PDF]

Archives of Biological Sciences
Anabasis articulata, commonly known as ‘ajrem’ or ‘eshnan’, is widely used in traditional medicine across the Arab world to alleviate ailments such as eczema, fever, and inflammatory diseases. Despite its extensive use, no prior studies have investigated
Makhlouf Yasmina, Bouaziz Amel, Hasnaoui Chahinez, Zourgui Lazhar, Dab Houcine, Yahia Boutheina, Benazi Nabil, Barghout Nihed, Bentahar Assia, Djidel Saliha, Khennouf Seddik, Dahamna Saliha   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evaluation of TNF-α and IFN-γ Levels in Macrophage of Preeclampsia Mice Model Induced by DOCA and L-NAME

Journal of Experimental Life Science
Preeclampsia is a pregnancy disorder characterized by high blood pressure, proteinuria, and chronic inflammation that potentially leads to multiorgan failure. This study investigated differences in the relative number of pro-inflammatory cytokines (IFN-γ
Winda Karina Susanti, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Sri Rahayu, Muhaimin Rifa’i, Muhammad Sasmito Djati   +5 more
doaj   +1 more source

Pharmacological evidence for connection of nitric oxide-mediated pathways in neuroprotective mechanism of ischemic postconditioning in mice

Journal of Pharmacy and Bioallied Sciences, 2014
Introduction: Postconditioning (PoCo) is an adaptive phenomenon whereby brief repetitive cycles of ischemia with intermittent reperfusion instituted immediately after prolonged ischemia at the onset of prolonged reperfusion elicit tissue protection. PoCo
Puja Gulati, Nirmal Singh
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hypotensive effect of extract of macerated garlic (Allium sativum) for 18 weeks in an in vivo experimental model

Revista Peruana de Medicina Experimental y Salud Pública, 2014
Objectives. Determine whether macerated extract of garlic (Allium sativum) for 18 weeks is equal to or better than Captopril in its hypotensive effect in rats. Materials and methods.
David Chaupis-Meza, Juan Rojas, Manuel Gasco, Gustavo F. Gonzales   +3 more
doaj   +1 more source