Results 41 to 50 of about 44,172 (240)

ADAM-17-independent shedding of L-selectin [PDF]

Journal of Leukocyte Biology, 2003
Abstract L-selectin is expressed by leukocytes and facilitates their adhesion under flow along the walls of blood vessels. As do a variety of membrane proteins, L-selectin undergoes ectodomain shedding. Using approaches that monitor full-length L-selectin in short-term assays, it has been determined that L-selectin shedding is defective ...
Bruce, Walcheck, Shelia R, Alexander, Catherine A, St Hill, Erik, Matala   +3 more
openaire   +2 more sources

Sulfhydryl Regulation of L-Selectin Shedding: Phenylarsine Oxide Promotes Activation-Independent L-Selectin Shedding from Leukocytes [PDF]

The Journal of Immunology, 2000
AbstractThe L-selectin adhesion molecule mediates leukocyte recruitment to inflammatory sites and lymphocyte trafficking through the peripheral lymph nodes. In response to leukocyte activation, L-selectin is proteolytically released from the cell surface, disabling leukocytes from the subsequent L-selectin-dependent interactions.
T A, Bennett, B S, Edwards, L A, Sklar, S, Rogelj   +3 more
openaire   +2 more sources

Lung-Derived Selectins Enhance Metastatic Behavior of Triple Negative Breast Cancer Cells

Biomedicines, 2021
The lung is one of the deadliest sites of breast cancer metastasis, particularly for triple negative breast cancer (TNBC). We have previously shown that the lung produces several soluble factors that may enhance the metastatic behavior of TNBC, including
Sami U. Khan, Ying Xia, David Goodale, Gabriella Schoettle, Alison L. Allan   +4 more
doaj   +1 more source

Immunohistochemical localization of adhesion molecules (CD62 and CD18) in the mammary gland of dairy cows

Czech Journal of Animal Science, 2007
Localization of the L-selectin (CD62L) and β2-integrin (CD18) bearing cells in different tissues of the bovine mammary gland was examined. Five dairy cows of Holstein-Friesian breed in the middle of their second and third lactation cycle were used in the
M. Simon, S. Hluchý, Ľ. Horovská, J. Antalíková, J. Čuboň   +4 more
doaj   +1 more source

Differential L-Selectin Binding Activities of Human Hematopoietic Cell L-Selectin Ligands, HCELL and PSGL-1 [PDF]

Journal of Biological Chemistry, 2001
Expression of L-selectin on human hematopoietic cells (HC) is associated with a higher proliferative activity and a more rapid engraftment after hematopoietic stem cell transplantation. Two L-selectin ligands are expressed on human HCs, P-selectin glycoprotein ligand-1 (PSGL-1) and a specialized glycoform of CD44 (hematopoietic cell E- and L-selectin ...
C J, Dimitroff, J Y, Lee, K S, Schor, B M, Sandmaier, R, Sackstein   +4 more
openaire   +2 more sources

CLINICAL AND IMMUNOLOGICAL CHANGES IN TREATMENT OF ADENOMYOSIS IN PATIENTS WITH INFERTILITY

Кубанский научный медицинский вестник, 2017
Aim. The aim of this study was to asses changes of adhesion molecules (L-selectin, neopterin and interleukin-6) in patients with adenomyosis-related infertility during the therapy.Materials and methods.
L. Yu. KARAKHALIS, A. R. JHIGALENKO, G. A. PENJHOYAN, N. V. KOLESNIKOVA   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Elevated serum L-selectin levels and decreased L-selectin expression on CD8+ lymphocytes in systemic sclerosis [PDF]

Clinical and Experimental Immunology, 2001
SUMMARYL-selectin is expressed on most circulating leucocytes and mediates leucocyte rolling on endothelium at sites of inflammation. Following rolling or activation of leucocytes, cell surface L-selectin is released as soluble L-selectin (sL-selectin).
Y, Shimada, M, Hasegawa, K, Takehara, S, Sato   +3 more
openaire   +2 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source