Results 31 to 40 of about 139,625 (161)
Neuroprotective effects of blockers for T-type calcium channels
Molecular Neurodegeneration, 2009 Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin +4 more
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Current Therapeutic Research, 2023 : Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD +4 more
doaj +1 more source
Psychostimulants, L-type Calcium Channels, Kinases, and Phosphatases [PDF]
The Neuroscientist, 2005 There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression.
Anjali M, Rajadhyaksha +1 more
openaire +2 more sources
Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons. [PDF]
PLoS ONE, 2014 Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy.
Allison Sargoy +3 more
doaj +1 more source
The Voltage-Gated Calcium Channel EGL-19 Acts on Glia to Drive Olfactory Adaptation
Frontiers in Molecular Neuroscience, 2022 Calcium channelopathies have been strongly linked to cardiovascular, muscular, neurological and psychiatric disorders. The voltage-gated calcium channels (VGCC) are vital transducers of membrane potential changes to facilitate the dynamics of calcium ...
Du Chen +17 more
doaj +1 more source
Anomalous L-Type Calcium Channels of Rat Spinal Motoneurons [PDF]
The Journal of General Physiology, 1999 Single channel patch-clamp recordings show that embryonic rat spinal motoneurons express anomalous L-type calcium channels, which reopen upon repolarization to resting potentials, displaying both short and long reopenings. The probability of reopening increases with increasing voltage of the preceding depolarization without any apparent correlation ...
HIVERT B +4 more
openaire +3 more sources
Neurobiology of Disease, 2004 Prions are transmissible pathogens that cause neurodegenerative diseases, although the mechanisms behind the nervous system dysfunctions are unclear.
Malin K Sandberg +3 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2013 Current schistosomiasis control strategies are largely based on chemotherapeutic agents and a limited number of drugs are available today. Praziquantel (PZQ) is the only drug currently used in schistosomiasis control programs.
Vanessa Silva-Moraes +6 more
doaj +1 more source
Modeling L-type Calcium Channel with Phenylalkylamines [PDF]
Biophysical Journal, 2009 Phenylalkylamines (PAAs), a major class of L-type calcium channel (LCC) blockers, have aromatic rings A and B connected by a flexible chain with cyano and ammonium groups proximal to rings A and B, respectively. Structural aspects of ligand-channel interactions remain unclear.
Cheng, Ricky C.K. +2 more
openaire +1 more source
An Indole Alkaloid Extracted from Evodia rutaecarpa Inhibits Colonic Motility of Rats In Vitro
Gastroenterology Research and Practice, 2020 Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa. Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown.
Guo-xiang Wang +4 more
doaj +1 more source