Results 41 to 50 of about 139,625 (161)

L-type calcium channel modulates cystic kidney phenotype

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
In polycystic kidney disease (PKD), abnormal proliferation and genomic instability of renal epithelia have been associated with cyst formation and kidney enlargement. We recently showed that L-type calcium channel (CaV1.2) is localized to primary cilia of epithelial cells.
Jin, Xingjian, Muntean, Brian S., Aal-Aaboda, Munaf S., Duan, Qiming, Zhou, Jing, Nauli, Surya M.   +5 more
openaire   +2 more sources

Role of Calcium Channels in the Protective Effect of Hydrogen Sulfide in Rat Cardiomyoblasts

Cellular Physiology and Biochemistry, 2014
Background: Hydrogen sulfide contributes to the reduction of oxidative stress-related injury in cardiomyocytes but the underlying mechanism is still unclear. Aims: Here we investigated the role of voltage-operated calcium channels (VOCCs) as mediators of
Daniele Avanzato, Annalisa Merlino, Sabina Porrera, Rui Wang, Luca Munaron, Daniele Mancardi   +5 more
doaj   +1 more source

Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

Neurobiology of Disease, 2000
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrPSc.
Stefano Thellung, Tullio Florio, Valentina Villa, Alessandro Corsaro, Sara Arena, Carolina Amico, Mauro Robello, Mario Salmona, Gianluigi Forloni, Orso Bugiani, Fabrizio Tagliavini, Gennaro Schettini   +11 more
doaj   +1 more source

T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. [PDF]

PLoS ONE, 2016
The process of calcium entry in T cells is a multichannel and multi-step process. We have studied the requirement for L-type calcium channels (Cav1.1) α1S subunits during calcium entry after TCR stimulation. High expression levels of Cav1.1 channels were
Didi Matza, Abdallah Badou, Kathryn G Klemic, Judith Stein, Usha Govindarajulu, Monica J Nadler, Jean-Pierre Kinet, Amnon Peled, Oz M Shapira, Leonard K Kaczmarek, Richard A Flavell   +10 more
doaj   +1 more source

Voltage-gated calcium channels: Their discovery, function and importance as drug targets

Brain and Neuroscience Advances, 2018
This review will first describe the importance of Ca 2+ entry for function of excitable cells, and the subsequent discovery of voltage-activated calcium conductances in these cells.
Annette C. Dolphin
doaj   +1 more source

Inactivation of L-type calcium channel modulated by HCN2 channel

American Journal of Physiology-Cell Physiology, 2010
Ca2+ entry is delicately controlled by inactivation of L-type calcium channel (LTCC) composed of the pore-forming subunit α1C and the auxiliary subunits β1 and α2δ. Calmodulin is the key protein that interacts with the COOH-terminal motifs of α1C, leading to the fine control of LTCC inactivation. In this study we show evidence that a hyperpolarization-
Yen-Chang, Lin, Jianying, Huang, Qi, Zhang, John M, Hollander, Jefferson C, Frisbee, Karen H, Martin, Casey, Nestor, Robert, Goodman, Han-Gang, Yu   +8 more
openaire   +3 more sources

Modeling L-type Calcium Channel with Dihydropyridines [PDF]

Biophysical Journal, 2009
Dyhydropyridines (DHPs) is a major class of L-type calcium channel (LCC) ligands, which have boat-like six-membered ring with NH-group at the stern, aromatic moiety at the bow, and various substituents at the port and starboard sides. DHPs demonstrate antagonistic or agonistic action, which was previously explained as stabilization or destabilization ...
Tikhonov, Denis B., Zhorov, Boris S.
openaire   +1 more source

Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis

EBioMedicine, 2020
Background: Previously, we found that amplification of chromosome 17q24.1-24.2 is associated with lymph node metastasis, tumour size, and lymphovascular invasion in invasive ductal carcinoma.
Nisha Kanwar, Katia Carmine-Simmen, Ranju Nair, Chunjie Wang, Soode Moghadas-Jafari, Heiko Blaser, Danh Tran-Thanh, Dongyu Wang, Peiqi Wang, Jenny Wang, Adrian Pasculescu, Alessandro Datti, Tak Mak, John D. Lewis, Susan J. Done   +14 more
doaj   +1 more source

Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling

Communications Biology, 2022
When present in the cytosol, a variety of peptides encoded by the distal carboxyl-termini of the L-type CaV1 calcium channels downregulate channel activity and neurite outgrowth.
Yaxiong Yang, Zhen Yu, Jinli Geng, Min Liu, Nan Liu, Ping Li, Weili Hong, Shuhua Yue, He Jiang, Haiyan Ge, Feng Qian, Wei Xiong, Ping Wang, Sen Song, Xiaomei Li, Yubo Fan, Xiaodong Liu   +16 more
doaj   +1 more source

Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation

Reviews in Cardiovascular Medicine
Atrial fibrillation (AF) is a prevalent and complex arrhythmia for which the pathogenesis involves various electrophysiological factors, notably the regulation of calcium channels.
Zuyuan Huang, Cheng Luo, Zimin Wu, Baoshi Zheng   +3 more
doaj   +1 more source