Results 51 to 60 of about 139,625 (161)

Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors

Neurobiology of Disease, 2009
Hypobaric hypoxia leads to cognitive dysfunctions due to increase in intracellular calcium through ion channels. The purpose of this study was to examine the temporal contribution of L-type calcium channels and N-methyl-D-aspartate receptors (NMDARs) in ...
Kalpana Barhwal, Sunil Kumar Hota, Iswar Baitharu, Dipti Prasad, Shashi Bala Singh, G. Ilavazhagan   +5 more
doaj   +1 more source

Calcium regulation of muscle spindle mechanosensory afferent function

Experimental Physiology
Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the
Anna Simon, Richard A. Lofthouse, Philip Miti, Claudiu V. Giuraniuc, Robert W. Banks, Guy S. Bewick   +5 more
doaj   +1 more source

12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels

Journal of Lipid Research, 2003
The lipoxygenase (LO) metabolite, 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], constricts renal vessels, contributes to the vascular response to angiotensin, and has been implicated in cardiovascular and renal diseases.
Shih Shen Yiu, Xueying Zhao, Edward W. Inscho, John D. Imig   +3 more
doaj   +1 more source

Bilirubin augments Ca2+ load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels

Scientific Reports, 2017
Neonatal brain is particularly vulnerable to pathological levels of bilirubin which elevates and overloads intracellular Ca2+, leading to neurotoxicity.
Min Liang, Xin-Lu Yin, Hai-Bo Shi, Chun-Yan Li, Xin-Yi Li, Ning-Ying Song, Hao-Song Shi, Yi Zhao, Lu-Yang Wang, Shan-Kai Yin   +9 more
doaj   +1 more source

Emerging roles of L-type voltage gated and other calcium channels in T lymphocytes.

Frontiers in Immunology, 2013
In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou, Mithilesh K. Jha, Didi eMatza, Richard A. Flavell, Richard A. Flavell   +4 more
doaj   +1 more source

Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels

Frontiers in Cellular Neuroscience, 2017
Modulation of ion channels by extracellular proteins plays critical roles in shaping synaptic plasticity. Retinoschisin (RS1) is an extracellular adhesive protein secreted from photoreceptors and bipolar cells, and it plays an important role during ...
Liheng Shi, Michael L. Ko, Gladys Y.-P. Ko, Gladys Y.-P. Ko   +3 more
doaj   +1 more source

Dysrhythmia due to Verapamil Overdose in a Young Woman

Case Reports in Cardiology
Verapamil (VER) is characterized as a calcium channel blocker (CCB) that can be intentionally or unintentionally overdosed. This drug, like other CCBs, inhibits the entry of calcium into vascular and myocardial tissues through L-type channels. VER exerts
Abdollah Malakian, Ensiyeh Taghizadeh, Zakaria Zakariaei   +2 more
doaj   +1 more source

Clustering of Ca_V 1.3 L-type calcium channels by Shank3. [PDF]

J Neurochem, 2023
Yang Q, Perfitt TL, Quay J, Hu L, Lawson-Qureshi D, Colbran RJ.   +5 more
europepmc   +1 more source

Nitric oxide signalling augments neuronal voltage-gated L-type (Ca(v)1) and P/q-type (Ca(v)2.1) channels in the mouse medial nucleus of the trapezoid body.

PLoS ONE, 2012
Nitric Oxide (NO) is a diffusible second messenger that modulates ion channels, intrinsic excitability and mediates synaptic plasticity. In light of its activity-dependent generation in the principal neurons of the medial nucleus of the trapezoid body ...
Adam J B Tozer, Ian D Forsythe, Joern R Steinert   +2 more
doaj   +1 more source

Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels. [PDF]

Channels (Austin), 2023
Heigl T, Netzer MA, Zanetti L, Ganglberger M, Fernández-Quintero ML, Koschak A.   +5 more
europepmc   +1 more source