Results 181 to 190 of about 13,174,260 (209)

Trypanosoma cruzi P21 protein exacerbates Leishmania (L.) amazonensis infection

Experimental Parasitology
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas disease, affects millions of people worldwide. Current treatments rely on drugs effective only in the acute phase, making the search for new therapeutic targets a priority. While a recombinant protein based on T.
Thaise Lara, Teixeira, Samuel Cota, Teixeira, Bruna Cristina, Borges, João Paulo Silva, Servato, Elida Cristina Monteiro de, Oliveira, Teresiama, Velikkakam, Claudio Vieira da, Silva   +6 more
openaire   +2 more sources

Melatonin attenuatesLeishmania (L.) amazonensisinfection by modulating arginine metabolism

Journal of Pineal Research, 2015
AbstractAcute inflammatory responses induced by bacteria or fungi block nocturnal melatonin synthesis by rodent pineal glands. Here, we showLeishmaniainfection does not impair daily melatonin rhythm in hamsters. Remarkably, the attenuated parasite burden and lesion progression in hamsters infected at nighttime was impaired by blockage of melatonin ...
Maria Fernanda, Laranjeira-Silva, Ricardo A, Zampieri, Sandra M, Muxel, Lucile Maria, Floeter-Winter, Regina P, Markus   +4 more
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Assessing the effects of Leishmania (Leishmania) infantum and L. (L.) amazonensis infections in macrophages using a quantitative proteome approach

Experimental Parasitology, 2022
Leishmania (Leishmania) infantum is the causative agent of visceral leishmaniasis, while L. (L.) amazonensis is associated with localized cutaneous and diffuse leishmaniasis, which can affect different organ tissues leading to visceral manifestations in some hosts.
Ivana H.R. Oliveira, Frank Kjeldsen, Marcella N. Melo-Braga, Thiago Verano-Braga, Hélida M. de Andrade   +4 more
openaire   +3 more sources

Assessing the composition of the plasma membrane of Leishmania (Leishmania) infantum and L. (L.) amazonensis using label-free proteomics

Experimental Parasitology, 2020
Protozoan parasites of the genus Leishmania are causative agents of leishmaniasis, a wide range of diseases affecting 12 million people worldwide. The species L. infantum and L. amazonensis are etiologic agents of visceral and cutaneous leishmaniasis, respectively.
Ivana H R, Oliveira, Henrique C P, Figueiredo, Cristiana P, Rezende, Thiago, Verano-Braga, Marcella N, Melo-Braga, João Luis, Reis Cunha, Hélida M, de Andrade   +6 more
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Antileishmanial activity of a naphthoquinone derivate against promastigote and amastigote stages of Leishmania infantum and Leishmania amazonensis and its mechanism of action against L. amazonensis species

Parasitology Research, 2017
Leishmaniasis has become a significant public health issue in several countries in the world. New products have been identified to treat against the disease; however, toxicity and/or high cost is a limitation. The present work evaluated the antileishmanial activity of a new naphthoquinone derivate, Flau-A [2-(2,3,4-tri-O-acetyl-6-deoxy-β-L ...
Débora Vasconcelos Costa Mendonça, Daniela Pagliara Lage, Stephane Lima Calixto, Flaviano Melo Ottoni, Grasiele de Sousa Vieira Tavares, Fernanda Ludolf, Miguel Angel Chávez-Fumagalli, Mônica Santos Schneider, Mariana Costa Duarte, Carlos Alberto Pereira Tavares, Ricardo José Alves, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho   +12 more
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Morphological alterations and growth inhibition of Leishmania (L.)amazonensis promastigotes exposed to zidovudine (AZT)

Parasitology Research, 2010
Leishmania parasites cause a worldwide public health disease and its treatment is still based on pentavalent antimonials which present financial and toxicologic limitations. Some nucleosidic derivatives have demonstrated anti-leishmanial properties and this study aims to evaluate the in vitro morphologic alterations and growth inhibition of Leishmania (
Carolina A, Araújo, Aline A, Araújo, Camilla L, Batista, Milton A P, Oliveira, Valeria, Oliveira, Ruy S, Lino Junior, Marina C, Vinaud, Jose C B, Bezerra   +7 more
openaire   +2 more sources

Pravastatin modulates macrophage functions of Leishmania (L.) amazonensis-infected BALB/c mice

Experimental Parasitology, 2013
The control of leishmaniases poses an important challenge due to the scarcity and toxicity of the pharmacological options available. We have previously shown that pravastatin significantly improves the course of the disease in Leishmania (L.) amazonensis-infected BALB/c mice.
Carlos S, Kückelhaus, Selma A S, Kückelhaus, Carlos Eduardo, Tosta, Maria Imaculada, Muniz-Junqueira   +3 more
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A radioiodinated peptidyl diazomethane detects similar cysteine proteinases in amastigotes and promastigotes ofLeishmania (L.) mexicana andL. (L.) amazonensis

Parasitology Research, 1995
Cysteine proteinase activities were examined in lesion amastigotes as well as in stationary-phase promastigotes of Leishmania (L.) mexicana and Leishmania (L.) amazonensis isolates. Enzyme detection in gelatin gels revealed that amastigotes of three L.
S C, Alfieri, J M, Balanco, E M, Pral
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Lantana camara L. induces a multi-targeted cell death process in Leishmania amazonensis

Journal of Ethnopharmacology
Lantana camara L. is a species known for its broad spectrum of bioactivities and is commonly used in folk therapy to address inflammatory, dermatological, gastrointestinal, intestinal worms and protozoan diseases. It boasts a diverse array of secondary metabolites such as terpenes, flavonoids, and saponins.
Ari Sérgio de Oliveira Lemos, Juliana da Trindade Granato, Luciana Maria Ribeiro Antinarelli, Patrícia de Almeida Machado, Lara Melo Campos, João Pedro Reis Costa Bastos, Victor do Valle Midlej, Adolfo Firmino da Silva Neto, Rodrigo Luiz Fabri, Elaine Soares Coimbra   +9 more
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Effect of Copaifera reticulata on amastigote forms of Leishmania (L.) amazonensis

Planta Medica, 2008
AO dos Santos, T Ueda-Nakamura, BPD Filho, VF da Veiga Jr, AC Pinto, CV Nakamura   +5 more
openaire   +1 more source