Results 251 to 260 of about 20,426,999 (313)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails <i>FDX1</i> Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance. [PDF]

Cancer Commun (Lond)
Wang W, Jiang X, Chen X, Liang K, Chen M, Lu K, Wei Q, Wu Y, Zhu L, Chen Y, Hou T, Luo J, Li C, Wang X, Jin H, Feng L.   +15 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4-Dependent Enhancer Activation. [PDF]

Adv Sci (Weinh)
Bhattarai PY, Vasukutty A, Na Y, Lim SC, Choi HS.   +4 more
europepmc   +1 more source

Malic enzyme 1 senses L-lactate to determine tumor heterogeneity. [PDF]

Signal Transduct Target Ther
Cao SY, Hu K, Huang S, Guan XL, Wang J, Shen Y, Ming H, Gu A, Wang C, Shen X, Wu Q, Chen Z, Yin M, Wen W, Lei QY.   +14 more
europepmc   +1 more source

Photodynamically Sensitized Mitochondrial-Damage Amplification Strategy Promotes Pyroptosis-Induced Immunotherapy of Osteosarcoma. [PDF]

Biomater Res
Ding T, Xiong T, Xu X, Sun Q, Liu M, Fang Z, Li Y, Wu Z, Zhang W, Zhou P, Bao H, He X, Wang T, Zhang C, Tian D, Huang F.   +15 more
europepmc   +1 more source

From Undifferentiated Connective Tissue Disease to Common Variable Immunodeficiency: A Novel NFKB1 Mutation in a Pediatric Case. [PDF]

Clin Case Rep
Hu YJ, Hao S, Feng D, Huang BX, Huang WY.   +4 more
europepmc   +1 more source

L-Glutamine and Cell Function

Japanese Journal of Clinical Chemistry, 2000
openaire   +1 more source