Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
Cell Reports, 2018 Summary: Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations can be
Mira Jeong +13 more
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Propagation of MM Virus in L Cells [PDF]
Applied Microbiology, 1969 MM virus (mouse-brain stock) replicated to a limited extent in L cells without cytopathic effects; the average yield was less than 1 plaque-forming unit/cell. Passage in BHK-21 cells resulted in MM virus [MM(BHK)] which replicated to high titers (200 to 300 plaque-forming units/cell) in L cells with complete cytopathic effects.
D J, Giron, F F, Pindak
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State of the Art of Fuel Cells for Ship Applications [PDF]
, 2012 Fuel cells promise to be far more efficient, produce lower or zero emissions, and operate cleaner than conventional internal-combustion engine and gas turbine. They are already used for transportation application (buses, cars and tramways).
HAN, Jingang +5 more
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What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? [PDF]
Frontiers in Endocrinology, 2021 Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and appetite, and include cardiovascular benefits and possibly also beneficial effects in neurodegenerative diseases.
Rune E. Kuhre +7 more
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Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells [PDF]
, 2006 Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells ...
Seaberg, R.M. +18 more
core +1 more source
L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy
Frontiers in Immunology, 2019 The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker, since expression is downregulated following engagement of the T cell receptor.
H. Angharad Watson +13 more
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ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections
Viruses, 2021 Host response to a viral infection includes the production of type I interferon (IFN) and the induction of interferon-stimulated genes that have broad antiviral effects.
Barkha Ramnani +3 more
doaj +1 more source
Sensitive superoxide detection in vascular cells by the new chemiluminescence dye L-012 [PDF]
, 1999 The detection superoxide production in vascular cells is usually limited by a low sensitivity of available assays, We tested the applicability of the luminol derivate L-012 {[}8-amino-5-chloro-7-phenylpyridol{[}3,4-d]pyridazine-l,4(2H,3H)dione] to ...
Sohn, Hae-Young +4 more
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Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells [PDF]
, 1991 Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells.
Kaissling, Brigitte +7 more
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Low-dose levodopa protects nerve cells from oxidative stress and up-regulates expression of pCREB and CD39. [PDF]
PLoS ONE, 2014 OBJECTIVE: This study aimed to investigate the influence of low-dose levodopa (L-DOPA) on neuronal cell death under oxidative stress. METHODS: PC12 cells were treated with L-DOPA at different concentrations. We detected the L-DOPA induced reactive oxygen
Shi-Ying Zhong +5 more
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