Results 21 to 30 of about 20,426,999 (313)
SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
Nature Communications, 2019 Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.
Qi Miao +8 more
doaj +1 more source
Using CRISPR/Cas9 to model human liver disease
JHEP Reports, 2019 Summary: CRISPR/Cas9 gene editing has revolutionised biomedical research. The ease of design has allowed many groups to apply this technology for disease modelling in animals. While the mouse remains the most commonly used organism for embryonic editing,
Michele Alves-Bezerra +3 more
doaj +1 more source
Medicine Science, 2022 To examine the effects of Mesenchymal Stem Cell-Lyophilizate (MSC-L) on the proliferation of A549 lung cancer cells and the activities of the JAK-STAT3 signaling pathway in this process.
Fatma Nilay Tutak, Haluk Uluca
doaj +1 more source
Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. [PDF]
, 2008 The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MPhi) effector functions: We show that whereas L ...
Corset, C +20 more
core +1 more source
Physicochemical Studies on L-Cell Virions [PDF]
Journal of Virology, 1973 The L-cell virion (LCV) has been purified from supernatant fluids of mouse L cells grown in suspension culture. The virion is similar to other RNA tumor viruses by several criteria: (i) the density of the virion is 1.16 g/cm 3 ; (ii) the virion appears as a rounded membranous particle with an outer diameter of 146.7
J L, Nichols, K, Quade, R B, Luftig
openaire +2 more sources
Characterising dye-sensitised solar cells [PDF]
, 2009 In today’s society there is a vast and in many cases not fully appreciated dependence on electrical power for everyday life. Furthermore, with growing energy and environmental concerns arising due to fossil fuel depletion and climate change/global ...
Zerulla, Dominic +9 more
core +1 more source
Stem Cell Reports, 2015 Analyses of gene expression in single mouse embryonic stem cells (mESCs) cultured in serum and LIF revealed the presence of two distinct cell subpopulations with individual gene expression signatures.
Dmitri Papatsenko +6 more
doaj +1 more source
Glucose Sensing in L Cells: A Primary Cell Study
Cell Metabolism, 2008 Glucagon-like peptide-1 (GLP-1) is an enteric hormone that stimulates insulin secretion and improves glycaemia in type 2 diabetes. Although GLP-1-based treatments are clinically available, alternative strategies to increase endogenous GLP-1 release from L cells are hampered by our limited physiological understanding of this cell type.
Reimann, Frank +5 more
openaire +2 more sources
Quantification of cathepsins B and L in cells [PDF]
Biochemical Journal, 1998 A method for quantifying active cysteine proteinases in mammalian cells has been developed using an active-site-directed inhibitor. Fluoren-9-ylmethoxycarbonyl(di-iodotyrosylalanyl)-diazomethane (Fmoc-[I2]Tyr-Ala-CHN2) was prepared and shown to react irreversibly with cathepsins B and L, but not with cathepsin S.
R, Xing, A K, Addington, R W, Mason
openaire +2 more sources
New Approaches to Treat Osteoarthritis with Mesenchymal Stem Cells
Stem Cells International, 2018 Osteoarthritis is one of the most common chronic health problems in the world that causes disability and chronic pain with reduced mobility and is a progressive degenerative disease in weight-bearing joints such as the knee.
Kiran Shah +2 more
doaj +1 more source