Results 11 to 20 of about 20,426,999 (313)

Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells. [PDF]

, 2013
Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T., Biology of Reproductive Cells, Pirity, M., Rungarunlert, Sasitorn, Klincumhom, Nuttha, Rungarunlert, S., Dinnyés, András, Tharasanit, Theerawat, Dep Gezondheidszorg Landbouwhuisdieren, Klincumhom, N., Techakumphu, M., Pirity, Melinda, Dinnyes, A.   +12 more
core   +2 more sources

DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A

Genome Biology, 2017
Background DNA methylation has widespread effects on gene expression during development. However, our ability to assign specific function to regions of DNA methylation is limited by the poor correlation between global patterns of DNA methylation and gene
Yung-Hsin Huang, Jianzhong Su, Yong Lei, Lorenzo Brunetti, Michael C. Gundry, Xiaotian Zhang, Mira Jeong, Wei Li, Margaret A. Goodell   +8 more
doaj   +1 more source

miR-33a-5p in small extracellular vesicles as non-invasive biomarker for oxaliplatin sensitivity in human colorectal cancer cells

Biochemistry and Biophysics Reports, 2021
microRNAs (miRNAs) contained in small extracellular vesicles (sEVs) are candidates for non-invasive biomarkers. Oxaliplatin (L-OHP) has been approved for advanced colorectal cancer (CRC) chemotherapy.
Shota Tanaka, Mika Hosokawa, Takumi Miyamoto, Aiko Nakagawa, Mika Haruna, Kumiko Ueda, Seigo Iwakawa, Ken-ichi Ogawara   +7 more
doaj   +1 more source

Homeobox oncogene activation by pan-cancer DNA hypermethylation

Genome Biology, 2018
Background Cancers have long been recognized to be not only genetically but also epigenetically distinct from their tissues of origin. Although genetic alterations underlying oncogene upregulation have been well studied, to what extent epigenetic ...
Jianzhong Su, Yung-Hsin Huang, Xiaodong Cui, Xinyu Wang, Xiaotian Zhang, Yong Lei, Jianfeng Xu, Xueqiu Lin, Kaifu Chen, Jie Lv, Margaret A. Goodell, Wei Li   +11 more
doaj   +1 more source

Nutrition and L and K-enteroendocrine cells [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2011
The review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are ...
Ruth, Gutierrez-Aguilar, Stephen C, Woods   +1 more
openaire   +2 more sources

L-arginine deprivation impairs Leishmania major-specific T-cell responses. [PDF]

, 2009
The amino acid L-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing ...
Markus Munder, Beak‐San Choi, Munder, Markus, Kropf, Pascale, Choi, Beak-San, Rogers, Matthew, Matthew Rogers, Pascale Kropf   +7 more
core   +1 more source

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

Genome Biology, 2018
Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be further oxidized ...
Tianpeng Gu, Xueqiu Lin, Sean M. Cullen, Min Luo, Mira Jeong, Marcos Estecio, Jianjun Shen, Swanand Hardikar, Deqiang Sun, Jianzhong Su, Danielle Rux, Anna Guzman, Minjung Lee, Lei Stanley Qi, Jia-Jia Chen, Michael Kyba, Yun Huang, Taiping Chen, Wei Li, Margaret A. Goodell   +19 more
doaj   +1 more source

GLP-1 localisation and proglucagon gene expression in healthy and diabetic mouse ileum

Journal of Veterinary Research, 2018
Glucagon-like peptide-1 (GLP-1) is a polypeptide that is mainly produced by intestinal L cells and is encoded by the proglucagon gene. In this study, GLP-1 localisation was investigated in the ileum of healthy and diabetic mice by immunohistochemistry ...
Taşçı Serap Koral, Bingöl Seyit Ali
doaj   +1 more source

Combinatorial Method/High Throughput Strategies for Hydrogel Optimization in Tissue Engineering Applications

Gels, 2016
Combinatorial method/high throughput strategies, which have long been used in the pharmaceutical industry, have recently been applied to hydrogel optimization for tissue engineering applications.
Laura A. Smith Callahan
doaj   +1 more source

Small poly-L-lysines improve cationic lipid-mediated gene transfer in vascular cells in vitro and in vivo [PDF]

, 2007
The potential of two small poly-L-lysines ( sPLLs), low molecular weight sPLL ( LMW-L) containing 7 - 30 lysine residues and L18 with 18 lysine repeats, to enhance the efficiency of liposome-mediated gene transfer ( GT) with cationic lipid DOCSPER {[}1,3-
Pelisek, Jaroslav, Rolland, Pierre-Henri, Nikol, Sigrid, Golda, Adam, Mekkaoui, Choukri, Engelmann, Markus G., Klocke, Rainer, Golda, Adam;Pelisek, Jaroslav;Klocke, Rainer;Engelmann, Markus G.;Rolland, Pierre-Henri;Mekkaoui, Choukri;Nikol, Sigrid, Golda, A;Pelisek, J;Klocke, R;Engelmann, MG;Rolland, PH;Mekkaoui, C;Nikol, S   +8 more
core   +1 more source