Results 51 to 60 of about 1,561,247 (279)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa   +3 more
wiley   +1 more source

Just in case…

open access: yesКлиническая и экспериментальная тиреоидология, 2017
The article discusses the problems of modern clinical, laboratory and visual diagnostics, in particular the problem of reference ranges, high prevalence of clinically insignificant abnormalities with the increasing risk of detection when the tests are ...
Valentin V. Fadeyev
doaj   +1 more source

Comparison of Different Labeling Techniques for the LC-MS Profiling of Human Milk Oligosaccharides

open access: yesFrontiers in Chemistry, 2021
Human milk oligosaccharides (HMOs) exhibit various biological activities for infants, such as serving as prebiotics, blocking pathogens, and aiding in brain development.
Yinzhi Lang   +9 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Image Labeling by Assignment

open access: yes, 2016
We introduce a novel geometric approach to the image labeling problem. Abstracting from specific labeling applications, a general objective function is defined on a manifold of stochastic matrices, whose elements assign prior data that are given in any ...
Petra, Stefania   +3 more
core   +1 more source

Biocompatible sulfonium-based covalent probes for endogenous tubulin fluorescence nanoscopy in live and fixed cells

open access: yesNature Communications
Fluorescent probes enable precise visualization of dynamic cellular processes, especially when combined with super-resolution imaging techniques that overcome the diffraction limit.
Marie Auvray   +4 more
doaj   +1 more source

Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications

open access: yesPharmaceuticals, 2016
Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits.
Christian Nienberg   +5 more
doaj   +1 more source

The Social Marginalization of People Living with a Mentally Ill Label–Family, Friends, and Work

open access: yesQualitative Sociology Review, 2021
This paper is based on qualitative research among people diagnosed with a mental illness who voluntarily attend a mental health center. Such individuals are given a degrading “mentally ill” label, which transforms them into a “new” person.
Kateřina Maloušková, Martin Fafejta
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Legal aspects of development of organic agriculture in Ukraine in the context of European integration [PDF]

open access: yesEkonomika Poljoprivrede (1979), 2020
In modern economic conditions, organic production is gaining global significance, partly addressing food security and contributing to the well-being of the population. Ukraine is in the top-20 of world leaders in the organic movement. In this regard, the
Ignatenko Iryna
doaj  

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