Results 51 to 60 of about 37,884 (225)
BMC Microbiology, 2020 Background The msaABCR operon regulates several staphylococcal phenotypes such as biofilm formation, capsule production, protease production, pigmentation, antibiotic resistance, and persister cells formation.
Gyan S. Sahukhal +4 more
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The Inducible lac Operator-Repressor System Is Functional in Zebrafish Cells
Frontiers in Genetics, 2021 BackgroundZebrafish are a foundational model organism for studying the spatio-temporal activity of genes and their regulatory sequences. A variety of approaches are currently available for editing genes and modifying gene expression in zebrafish ...
Sierra S. Nishizaki +8 more
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Supercoiling Effects on Short-Range DNA Looping in E. coli. [PDF]
PLoS ONE, 2016 DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades.
Lauren S Mogil +2 more
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Switching off: the phenotypic transition to the uninduced state of the lactose uptake pathway [PDF]
, 2021 The lactose uptake-pathway of E. coli is a paradigmatic example of multistability in gene-regulatory circuits. In the induced state of the lac-pathway, the genes comprising the lac-operon are transcribed, leading to the production of proteins which import and metabolize lactose.
arxiv +1 more source
Growth rate regulation of lac operon expression in Escherichia coli is cyclic AMP dependent [PDF]
, 2003 In contrast to the ribosomal RNA gene expression increasing with growth rate, transcription of the lac operon is downregulated by cell growth rate. In continuous culture, growth rate regulation of lac promoter was independent of carbon substrate used and
Chang, Yu-Jen +2 more
core +1 more source
Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics
Molecular Therapy: Nucleic Acids, 2013 Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for ...
Mark Stevenson +9 more
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MicrobiologyOpen, 2019 Bacteria can utilize diverse sugars as carbon and energy source, but the regulatory mechanisms directing the choice of the preferred substrate are often poorly understood.
Tamara Aleksandrzak‐Piekarczyk +2 more
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Biomedical and Biotechnology Research Journal, 2022 Background: The repeating elements in the genes or genomes of living organisms are associated with a variety of functions at the molecular level. Mirror repeats (MRs) are unique type of repeat sequences among them, which are found to be linked with H-DNA
Sandeep Yadav +2 more
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CRISPR SWAPnDROP -- A multifunctional system for genome editing and large-scale interspecies gene transfer [PDF]
, 2021 The need for diverse chromosomal modifications in biotechnology, synthetic biology and basic research requires the development of new technologies. With CRISPR SWAPnDROP, we extend the limits of genome editing to large-scale in-vivo DNA transfer between bacterial species.
arxiv +1 more source
Use of a Role-Playing Activity To Increase Student Understanding of Bacterial Gene Regulation
Journal of Microbiology & Biology Education, 2023 Undergraduate students often struggle to understand the basics of bacterial gene regulation, a key concept in microbiology. They find it hard to visualize the architecture of a bacterial operon or how the gene, RNA, and protein components interact with ...
Vinaya Sampath
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