Results 11 to 20 of about 50,722 (240)

Biologically Active 1-Arylpiperazines. Synthesis of New N-(4-Aryl-1-piperazinyl)alkyl Derivatives of Quinazolidin-4(3H)-one, 2,3-Dihydrophthalazine-1,4-dione and 1,2-Dihydropyridazine-3,6-dione as Potential Serotonin Receptor Ligands

Molecules, 2001
The synthesis of a series of new n-propyl and n-butyl chain containing 1-arylpiperazine derivatives of quinazolidin-4(3H)-one (7) 2-phenyl-2,3-dihydrophthalazine-1,4-dione (8) and 1-phenyl-1,2-dihydropyridazine-3,6-dione (9) as potential serotonin ...
Sijka Charakchieva-Minol, Andrzej J. Bojarski, Maria J. Mokrosz, Teresa Kowalska, Piotr Kowalski   +4 more
doaj   +1 more source

Synthesis of a tricyclic lactam via Beckmann rearrangement and ring-rearrangement metathesis as key steps

Beilstein Journal of Organic Chemistry, 2015
A tricyclic lactam is reported in a four step synthesis sequence via Beckmann rearrangement and ring-rearrangement metathesis as key steps. Here, we used a simple starting material such as dicyclopentadiene.
Sambasivarao Kotha, Ongolu Ravikumar, Jadab Majhi   +2 more
doaj   +1 more source

Fast Solvent-free Alkylation of Amides and Lactams under Microwave Irradiation

Molecules, 1999
N-Substituted amides and lactams are rapidly N-alkylated under solvent-free phase-transfer catalytic conditions using microwaves.
Dariusz Bogdal
doaj   +1 more source

Fungal Lactamases: Their Occurrence and Function

Frontiers in Microbiology, 2017
Fungi are absorptive feeders and thus must colonize and ramify through their substrate to survive. In so doing they are in competition, particularly in the soil, with myriad microbes.
Minglu Gao, Anthony E. Glenn, Alex A. Blacutt, Scott E. Gold   +3 more
doaj   +1 more source

Ni-catalyzed carbamoylation of unactivated alkenes for stereoselective construction of six-membered lactams

Nature Communications, 2022
Six-membered chiral lactams are common structural motifs of pharmaceuticals. Here, the authors describe a nickel-catalyzed reductive carbamoylation of alkenes to form enantioenriched six-membered lactams.
Chenhuan Zhang, Xianqing Wu, Tingting Xia, Jingping Qu, Yifeng Chen   +4 more
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A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source

Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position

Frontiers in Chemistry, 2019
Mono- and disubstituted 4-CF3 β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.
Monika Skibińska, Monika Skibińska, Marcin Kaźmierczak, Marcin Kaźmierczak, Thierry Milcent, Tomasz Cytlak, Tomasz Cytlak, Henryk Koroniak, Benoit Crousse   +8 more
doaj   +1 more source

Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast [version 1; peer review: 2 approved]

F1000Research, 2021
Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs.
Erika Rodríguez Cavallo, Darío Méndez Cuadro, Albeiro Marrugo Padilla, Johana Marquez   +3 more
doaj   +1 more source

p-Nitrophenyl carbonate promoted ring-opening reactions of DBU and DBN affording lactam carbamates

Beilstein Journal of Organic Chemistry, 2016
The amidine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and DBN (1,5-diazabicyclo[4.3.0]non-5-ene) display nucleophilic behaviour towards highly electrophilic p-nitrophenyl carbonate derivatives with ring opening of the bicyclic ring to form ...
Madhuri Vangala, Ganesh P Shinde
doaj   +1 more source

β-Lactams from the Ocean

Marine Drugs, 2023
The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria ...
Jed F. Fisher, Shahriar Mobashery
doaj   +1 more source