Results 11 to 20 of about 16,821 (255)
Association between functional lactase variants and a high abundance of Bifidobacterium in the gut of healthy Japanese people. [PDF]
PLoS ONE, 2018 Previous studies have shown that Japanese people exhibit a higher abundance of Bifidobacterium compared to people from other countries. Among the possible factors affecting the gut microbiota composition, an association of functional lactase gene ...
Kumiko Kato +5 more
doaj +2 more sources
Scientific Reports, 2018 In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the −13910C > T, but also others, are ...
Milena N. Leseva +6 more
doaj +2 more sources
Genetics and Molecular Biology, 2017 Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek +5 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Background This study investigated the effects of Baohe pill decoction on the diversity and community composition of lactase-producing bacteria in the intestinal contents of mice with diarrhea induced by high-fat and high-protein diet, which provided an ...
K. Zhou +5 more
semanticscholar +1 more source
Examination of runs of homozygosity in relation to height in an endogamous Namibian population
American Journal of Biological Anthropology, Volume 180, Issue 1, Page 207-215, January 2023., 2023 Abstract Objectives Height is a complex, highly heritable polygenic trait subject to both genetic composition and environmental influences. Recent studies suggest that a large proportion of height heritability is determined by the cumulative effect of many low allele frequency variants across the genome. Previous research has also identified an inverse
Natalie Swinford +6 more
wiley +1 more source
ChemPlusChem, Volume 87, Issue 12, December 2022., 2022 A deeper understanding regarding the enzyme‐carrier interactions and the enzyme conformation may bring clues about the inherent processes that occur during enzyme immobilization. In this study, the enzyme β‐galactosidase was immobilized on a meso‐macroporous silica carrier, and infrared spectroscopy allowed the search for such clues to explain the ...
Diogo Videira‐Quintela +3 more
wiley +1 more source
Human Molecular Genetics, 2021 Lactase persistence is a genetically-determined trait that is prevalent in African, European and Arab populations with a tradition of cattle herding and milk consumption.
M. Campbell, A. Ranciaro
semanticscholar +1 more source
Improved Gold Nanoprobes for Detection of Single Nucleotide Polymorphisms: The Influence of Size
Particle &Particle Systems Characterization, Volume 39, Issue 12, December 2022., 2022 Unique plasmonic properties of gold nanoparticles (AuNPs) are used for detection of a single nucleotide polymorphism related to lactose intolerance. Assays based on 20 nm and 35 nm AuNPs functionalized with specific oligonucleotide probes are compared and found that 35 nm AuNPs allow a reduction of 80% and 48% in the amount of gold and oligonucleotide ...
Maria Enea +7 more
wiley +1 more source
Nutrients, 2020 Lactose intolerance (LI) is characterized by the presence of primarily gastrointestinal clinical signs resulting from colonic fermentation of lactose, the absorption of which is impaired due to a deficiency in the lactase enzyme. These clinical signs can
R. Leis +4 more
semanticscholar +1 more source
PLoS Biology, 2020 The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Ségurel +8 more
semanticscholar +1 more source