Results 71 to 80 of about 24,421 (251)

Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent PPARγ and Nrf2 Agonist That Mitigates Colon Inflammation

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Peroxisome proliferator‐activated receptors (PPARs), functioning as nuclear receptors, regulate the expression of genes associated with inflammation, lipid metabolism, and glucose metabolism. The primary isotypes of PPARs are PPARα, PPARβ, and PPARγ. PPARγ is mostly expressed in adipose tissue and the colon.
Aya A. Touny, Balaji Venkataraman, Saeeda Almarzooqi, Rajesh B. Patil, Bhoomendra A. Bhongade, Miroslav Harjaček, Tahir A. Rizvi, Shreesh Ojha, Shamanth Neralagundi Harihar Gowdru, Sandeep B. Subramanya   +9 more
wiley   +1 more source

Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets [PDF]

, 2020
The monoterpene thymol has been proposed as a valuable alternative to in-feed antibiotics in animal production. However, the effectiveness of the antimicrobial is comprised by its fast absorption in the upper gastrointestinal tract.
De Smet, Stefaan, Degroote, Jeroen, Desmet, Tom, Michiels, Joris, Van Liefferinge, Elout, Van Noten, Noémie   +5 more
core   +1 more source

Analysis of lactase processing in rabbit

FEBS Letters, 1993
The proteolytic processing of rabbit intestinal lactase‐phlorizin‐hydrolase (LPH) was studied by pulse‐chase and continuous labeling experiments in organ culture from 15‐day‐old rabbits in the presence of glycosylation and processing inhibitors. Monensin and brefeldin A inhibited the two proteolytic cleavages of the precursor indicating that they are ...
ROSSI M, MAIURI, Luigi, SALVATI VM, RUSSOMANNO C, AURICCHIO S.   +4 more
openaire   +3 more sources

Pathogenic Deep Intronic PCSK1 Variant Causes Proprotein Convertase 1/3 Deficiency in a Family

Clinical Genetics, Volume 108, Issue 1, Page 102-106, July 2025.
Biallelic PCSK1 loss‐of‐function mutations cause proprotein convertase 1/3 (PC1/3) deficiency, a polyendocrinopathy; a total of 36 patients were reported. The first deep intronic PCSK1 variant, (NM_000439.5):c.1196+2681T>A, was found to segregate with the disease in a consanguineous family, and is shown together with 32 reported mutations.
Leah M. Huber, Aslı Subaşıoğlu, Dorota Garczarczyk‐Asim, Taras Valovka, Thomas Müller, Rüdiger Adam, Andreas R. Janecke   +6 more
wiley   +1 more source

Safety evaluation of an extension of use of the food enzyme β‐galactosidase from the genetically modified Aspergillus niger strain TOL

EFSA Journal, Volume 23, Issue 7, July 2025.
Abstract The food enzyme β‐galactosidase (β‐d‐galactoside galactohydrolase, EC 3.2.1.23) is produced with the genetically modified Aspergillus niger strain TOL by DSM Food Specialties B.V. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in one food
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Daniele Cavanna, Yi Liu   +14 more
wiley   +1 more source

The Effects of Exogenous Lactase on Improving Gastrointestinal Symp-toms in Patients with Lactose Intolerance

مجله دانشکده پزشکی اصفهان, 2011
Background: Lactose intolerance is common in Asian population. Enzyme replacement therapy facilitates consumption of milk and dairy products for patients with lactose intolerance. Clinical evidence in our clinics indicates a nonhomogeneity in improvement
Ramin Ghahremani, Behzad Asanjarani
doaj  

Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms

BMC Gastroenterology, 2009
Background Oxytocin and the oxytocin receptor have been demonstrated in the gastrointestinal (GI) tract and have been shown to exert physiological effects on gut motility. The role for oxytocin in the pathophysiology of GI complaints is unknown.
Simrén Magnus, Carlson Joyce, Truedsson Mikael, Ohlsson Bodil   +3 more
doaj   +1 more source

Probiotics—compensation for lactase insufficiency [PDF]

The American Journal of Clinical Nutrition, 2001
Yogurt and other conventional starter cultures and probiotic bacteria in fermented and unfermented milk products improve lactose digestion and eliminate symptoms of intolerance in lactose maldigesters. These beneficial effects are due to microbial beta-galactosidase in the (fermented) milk product, delayed gastrointestinal transit, positive effects on ...
Anna Stegelmann, Susanne Fenselau, C. Laue, Bernd Richter, Michael de Vrese, Jürgen Schrezenmeir   +5 more
openaire   +3 more sources

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, Volume 19, Issue 6, Page 1737-1750, June 2025.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

LACTASE DEFICIENCY IN CHILDREN

Педиатрическая фармакология, 2011
The topic of the article is the lactase deficiency in children. The most frequent clinical manifestations — diarrhea and flatulence —are not specific to this pathology. Symptoms, typical for the majority of the diseases nosologies of the digestive system,
V.A. Shcherbak, N.M. Shcherbak
doaj   +2 more sources