Results 1 to 10 of about 326,261 (230)

Dairying and the evolution and consequences of lactase persistence in humans. [PDF]

Anim Front, 2023
A stable and consistent food source is one of the most important evolutionary challenges facing any species. Mammalian young are typically born incapable of provisioning for themselves, but all mammalian species, through the production of milk, have ...
Stock JT, Wells JCK.
europepmc   +7 more sources

The molecular basis of lactase persistence: Linking genetics and epigenetics. [PDF]

Ann Hum Genet
Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations ...
Cohen CE, Swallow DM, Walker C.
europepmc   +4 more sources

Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]

Frontiers in Physiology, 2021
The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Jonathan C. K. Wells, Emma Pomeroy, Jay T. Stock, Jay T. Stock   +3 more
doaj   +6 more sources

Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas [PDF]

Frontiers in Genetics, 2021
In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Ana Cecília Guimarães Alves, Ana Cecília Guimarães Alves, Natalie Mary Sukow, Gabriel Adelman Cipolla, Marla Mendes, Thiago P. Leal, Maria Luiza Petzl-Erler, Maria Luiza Petzl-Erler, Ricardo Lehtonen Rodrigues Souza, Ricardo Lehtonen Rodrigues Souza, Ilíada Rainha de Souza, Ilíada Rainha de Souza, Cesar Sanchez, Meddly Santolalla, Douglas Loesch, Michael Dean, Moara Machado, Jee-Young Moon, Robert Kaplan, Robert Kaplan, Kari E. North, Scott Weiss, Mauricio L. Barreto, Mauricio L. Barreto, M. Fernanda Lima-Costa, M. Fernanda Lima-Costa, Heinner Guio, Heinner Guio, Omar Cáceres, Omar Cáceres, Carlos Padilla, Eduardo Tarazona-Santos, Ignacio F. Mata, Ignacio F. Mata, Ignacio F. Mata, Elena Dieguez, Víctor Raggio, Andres Lescano, Vitor Tumas, Vanderci Borges, Henrique B. Ferraz, Carlos R. Rieder, Artur Schumacher-Schuh, Artur Schumacher-Schuh, Bruno L. Santos-Lobato, Pedro Chana-Cuevas, William Fernandez, Gonzalo Arboleda, Humberto Arboleda, Carlos E. Arboleda-Bustos, Timothy D. O’Connor, Timothy D. O’Connor, Timothy D. O’Connor, Marcia Holsbach Beltrame, Marcia Holsbach Beltrame, Victor Borda   +55 more
doaj   +3 more sources

Development of a novel SNP assay to detect lactase persistence associated genetic variants. [PDF]

Mol Biol Rep, 2021
In adulthood the activity of the lactase enzyme is inherited as autosomal dominant form associated to Single nucleotide polymorphisms (SNPs). The present research was aimed to develop a novel genetic method to test lactase non persistence more powerfully.
De Luca P, Iaconis D, Biffali E, Enza C, de Magistris L, Riegler G, Pappalardo D, Amato MR, Iardino P, Montanino C, De Felice B.   +10 more
europepmc   +4 more sources

Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification [PDF]

Heliyon
The single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Almuthanna K. Alkaraki, Miguel A. Alfonso-Sánchez, Jose A. Peña, Alanoud I. Abuelezz   +3 more
doaj   +3 more sources

Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent [PDF]

Frontiers in Genetics, 2020
Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks
Shannon E. K. Joslin, Blythe P. Durbin-Johnson, Blythe P. Durbin-Johnson, Monica Britton, Matthew L. Settles, Ian Korf, Ian Korf, Danielle G. Lemay, Danielle G. Lemay, Danielle G. Lemay   +9 more
doaj   +3 more sources

Neanderthal adaptive introgression shaped <i>LCT</i> enhancer region diversity without linking to lactase persistence in East Asian populations. [PDF]

Proc Natl Acad Sci U S A
Significance Positive selection at the 2q21.3 locus in Europeans and Africans has long been tied to lactase persistence (LP) and milk-drinking and is a textbook example of convergent evolution and gene–culture coevolution.
Ma X, Lu Y, Stoneking M, Xu S.
europepmc   +3 more sources

Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]

PLoS Biology, 2020
The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Segurel, Perle Guarino-Vignon, Nina Marchi, Sophie Lafosse, Romain Laurent, Céline Bon, Alexandre Fabre, Tatyana Hegay, Evelyne Heyer   +8 more
doaj   +3 more sources

Lactase Persistence-Associated rs4988235 Polymorphism: A Novel Genetic Link to Cardiovascular Risk via Modulation of ApoB100 and ApoAI. [PDF]

Nutrients
Background/Objectives: As part of the human adaptation to dairy consumption, the presence of the rs4988235-T variant in the MCM6 gene primarily determines lactase persistence in adult European populations, increasing the expression of the lactase ...
Kharrat Helu N, Al Ashkar H, Kovacs N, Adany R, Piko P.   +4 more
europepmc   +3 more sources