A worldwide correlation of lactase persistence phenotype and genotypes [PDF]
BMC Evolutionary Biology, 2010 Background The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Ingram Catherine JE +4 more
doaj +11 more sources
World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection [PDF]
Human Genetics, 2017 The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G ...
Anke Liebert, Saioa López, Winston Lau
exaly +10 more sources
Milk intake, lactase persistence genotype, plasma proteins and risks of cardiovascular events in the Swedish general population. [PDF]
Eur J Epidemiol, 2023 To investigate the associations of milk intake (non-fermented and fermented milk), lactase persistence ( LCT -13910 C/T) genotype (a proxy for long-term non-fermented milk intake), and gene-milk interaction with risks of cardiovascular disease (CVD) and ...
Zhang S +6 more
europepmc +4 more sources
Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait [PDF]
BMC Genomics, 2019 Background Human population history in the Holocene was profoundly impacted by changes in lifestyle following the invention and adoption of food-production practices.
Mário Vicente +6 more
doaj +5 more sources
Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]
Frontiers in Physiology, 2021 The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Jonathan C. K. Wells +3 more
doaj +3 more sources
The molecular basis of lactase persistence: Linking genetics and epigenetics. [PDF]
Ann Hum GenetLactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations ...
Cohen CE, Swallow DM, Walker C.
europepmc +4 more sources
Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas [PDF]
Frontiers in Genetics, 2021 In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Ana Cecília Guimarães Alves +55 more
doaj +3 more sources
Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent [PDF]
Frontiers in Genetics, 2020 Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks
Shannon E. K. Joslin +9 more
doaj +3 more sources
Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification [PDF]
HeliyonThe single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Almuthanna K. Alkaraki +3 more
doaj +3 more sources
Association of Lactase Persistence Genotypes (rs4988235) and Ethnicity with Dairy Intake in a Healthy U.S. Population. [PDF]
Nutrients, 2019 Lactase persistence (LP) is a trait in which lactose can be digested throughout adulthood, while lactase non-persistence (LNP) can cause lactose intolerance and influence dairy consumption.
Chin EL +10 more
europepmc +4 more sources