Results 1 to 10 of about 371,453 (180)

Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]

PLoS Biol, 2020
The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Segurel L, Guarino-Vignon P, Marchi N, Lafosse S, Laurent R, Bon C, Fabre A, Hegay T, Heyer E.   +8 more
europepmc   +4 more sources

Ileal Lactase Expression Associates with Lactase Persistence Genotypes. [PDF]

Nutrients, 2021
(1) Background: Lactose digestion depends on persistence genotypes (including rs4988235), the frequency of which exhibits broad geographical variability.
Nowak JK, Dybska E, Dworacka M, Tsikhan N, Kononets V, Bermagambetova S, Walkowiak J.   +6 more
europepmc   +4 more sources

Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]

Front Physiol, 2021
The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Wells JCK, Pomeroy E, Stock JT.
europepmc   +3 more sources

Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas. [PDF]

Front Genet, 2021
In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Guimarães Alves AC, Sukow NM, Adelman Cipolla G, Mendes M, Leal TP, Petzl-Erler ML, Lehtonen Rodrigues Souza R, Rainha de Souza I, Sanchez C, Santolalla M, Loesch D, Dean M, Machado M, Moon JY, Kaplan R, North KE, Weiss S, Barreto ML, Lima-Costa MF, Guio H, Cáceres O, Padilla C, Tarazona-Santos E, Mata IF, Dieguez E, Raggio V, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher-Schuh A, Santos-Lobato BL, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda-Bustos CE, O'Connor TD, Beltrame MH, Borda V.   +40 more
europepmc   +3 more sources

Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification. [PDF]

Heliyon
The single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Alkaraki AK, Alfonso-Sánchez MA, Peña JA, Abuelezz AI.   +3 more
europepmc   +3 more sources

The Origins of Lactase Persistence in Europe

PLoS Computational Biology, 2009
Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world.
Yuval Itan, Mark G Thomas
exaly   +10 more sources

Dairying, diseases and the evolution of lactase persistence in Europe. [PDF]

Nature, 2022
Evershed RP, Davey Smith G, Roffet-Salque M, Timpson A, Diekmann Y, Lyon MS, Cramp LJE, Casanova E, Smyth J, Whelton HL, Dunne J, Brychova V, Šoberl L, Gerbault P, Gillis RE, Heyd V, Johnson E, Kendall I, Manning K, Marciniak A, Outram AK, Vigne JD, Shennan S, Bevan A, Colledge S, Allason-Jones L, Amkreutz L, Anders A, Arbogast RM, Bălăşescu A, Bánffy E, Barclay A, Behrens A, Bogucki P, Carrancho Alonso Á, Carretero JM, Cavanagh N, Claßen E, Collado Giraldo H, Conrad M, Csengeri P, Czerniak L, Dębiec M, Denaire A, Domboróczki L, Donald C, Ebert J, Evans C, Francés-Negro M, Gronenborn D, Haack F, Halle M, Hamon C, Hülshoff R, Ilett M, Iriarte E, Jakucs J, Jeunesse C, Johnson M, Jones AM, Jones AM, Karul N, Kiosak D, Kotova N, Krause R, Kretschmer S, Krüger M, Lefranc P, Lelong O, Lenneis E, Logvin A, Lüth F, Marton T, Marley J, Mortimer R, Oosterbeek L, Oross K, Pavúk J, Pechtl J, Pétrequin P, Pollard J, Pollard R, Powlesland D, Pyzel J, Raczky P, Richardson A, Rowe P, Rowland S, Rowlandson I, Saile T, Sebők K, Schier W, Schmalfuß G, Sharapova S, Sharp H, Sheridan A, Shevnina I, Sobkowiak-Tabaka I, Stadler P, Stäuble H, Stobbe A, Stojanovski D, Tasić N, van Wijk I, Vostrovská I, Vuković J, Wolfram S, Zeeb-Lanz A, Thomas MG.   +108 more
europepmc   +3 more sources

Strain-Level Analysis of Bifidobacterium spp. from Gut Microbiomes of Adults with Differing Lactase Persistence Genotypes. [PDF]

mSystems, 2020
One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Schmidt V, Enav H, Spector TD, Youngblut ND, Ley RE.   +4 more
europepmc   +3 more sources

Dairy Production and Lactase Persistence in Humans. [PDF]

Anim Front, 2023
europepmc   +4 more sources

Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait. [PDF]

BMC Genomics, 2019
Background Human population history in the Holocene was profoundly impacted by changes in lifestyle following the invention and adoption of food-production practices.
Vicente M, Priehodová E, Diallo I, Podgorná E, Poloni ES, Černý V, Schlebusch CM.   +6 more
europepmc   +3 more sources