In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence [PDF]
, 2016 The genetic trait that allows intestinal lactase to persist into adulthood in some 35% of humans worldwide operates at the level of transcription, the effect being caused by cis-acting nucleotide changes upstream of the lactase gene (LCT).
Danielsen, ET +5 more
core +2 more sources
Evolution of the human fear-circuitry and acute sociogenic pseudoneurological symptoms: The Neolithic balanced-polymorphism hypothesis [PDF]
, 2005 In light of the increasing threat of large-scale massacres such as terrorism against non-combatants (civilians), more attention is warranted not only to posttraumatic stress disorder (PTSD) but also to acute sociogenic pseudoneurological ("conversion ...
Bracha, Dr. H. Stefan +3 more
core +1 more source
Documenta Praehistorica, 2013 The ability to digest milk during adulthood (lactase persistence) is a genetically determined trait present only in humans. Its origin and diffusion are correlated with the development of pastoralism and the consumption of fresh milk.
Michela Leonardi
doaj +1 more source
The Onset of Lactase Persistence in Europe [PDF]
Human Heredity, 2013 The genomic region containing the lactase (LCT) gene shows one of the strongest signals of positive selection in Europeans, detectable using a range of approaches including haplotype length, linked microsatellite variation and population-differentiation-based tests. Lactase is the enzyme that carries out the digestion of the milk sugar lactose.
openaire +2 more sources
Genetic diversity of lactase persistence in East African populations. [PDF]
BMC Res Notes, 2016 The expression of lactase which digests lactose from milk in humans is generally lost after weaning, but selected mutations influencing the promoter of the lactase gene have spread into the human populations. This is considered a classical example of gene-culture co-evolution, and several studies suggested that the lactase gene has been under strong ...
Hassan HY +6 more
europepmc +6 more sources
Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population. [PDF]
PLoS ONE, 2012 Adult-type hypolactasia is a common phenotype caused by the lactase enzyme deficiency. The -13910 C>T polymorphism, located 14 Kb upstream of the lactase gene (LCT) in the MCM6 gene was associated with lactase persistence (LP) in Europeans.
Deise C Friedrich +3 more
doaj +1 more source
Excellent agreement between genetic and hydrogen breath tests for lactase deficiency and the role of extended symptom assessment [PDF]
, 2010 Clinical manifestations of lactase (LCT) deficiency include intestinal and extra-intestinal symptoms. Lactose hydrogen breath test (H2-BT) is considered the gold standard to evaluate LCT deficiency (LD).
A. v. Eckardstein +13 more
core +3 more sources
BMC Research Notes, 2010 Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts.
Morgan Angharad R +6 more
doaj +1 more source
Nutrient Estimation from 24-Hour Food Recalls Using Machine Learning and Database Mapping: A Case Study with Lactose. [PDF]
, 2019 The Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) is a free dietary recall system that outputs fewer nutrients than the Nutrition Data System for Research (NDSR).
Bouzid, Yasmine Y +6 more
core +2 more sources
Scientific Reports, 2018 In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the −13910C > T, but also others, are ...
Milena N. Leseva +6 more
doaj +1 more source