Results 31 to 40 of about 360,868 (176)
World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection. [PDF]
Hum Genet, 2017 The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G ...
Liebert A +9 more
europepmc +2 more sources
Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population
Annals of Human Biology, 2022 Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase
Stefan Németh +5 more
doaj +1 more source
The molecular basis of lactase persistence: Linking genetics and epigenetics. [PDF]
Ann Hum GenetAbstractLactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Cohen CE, Swallow DM, Walker C.
europepmc +3 more sources
The evolution of lactase persistence in Europe. A synthesis of archaeological and genetic evidence
, 2012 Lactase persistence, the ability to digest the milk sugar lactose in adulthood, is highly associated with a T allele situated 13,910 bp upstream from the actual lactase gene in Europeans.
Thomas, M.G. +11 more
core +2 more sources
Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population. [PDF]
PLoS ONE, 2012 Adult-type hypolactasia is a common phenotype caused by the lactase enzyme deficiency. The -13910 C>T polymorphism, located 14 Kb upstream of the lactase gene (LCT) in the MCM6 gene was associated with lactase persistence (LP) in Europeans.
Deise C Friedrich +3 more
doaj +1 more source
BMC Research Notes, 2010 Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts.
Morgan Angharad R +6 more
doaj +1 more source
Scientific Reports, 2018 In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the −13910C > T, but also others, are ...
Milena N. Leseva +6 more
doaj +1 more source
Why Anthropologists Should Study Dogs [PDF]
Evol AnthropolABSTRACT While primates have traditionally been a focus of evolutionary anthropologists, the domestic dog represents a valuable complementary model due to its long shared evolutionary history with humans. The advantages of studying dogs are particularly evident in four key areas: (1) analyzing evolutionary adaptations, (2) understanding humanity's past,
Smith K.
europepmc +2 more sources
World Allergy Organization Journal, 2017 Lactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed.
Ralf G. Heine +9 more
doaj +3 more sources
Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption. [PDF]
PLoS ONE, 2018 BACKGROUND:Current literature proposes associations between homocysteine (HCY), folic acid (FA), vitamin B12 metabolism and depression. However, the exact underlying biological mechanisms remain unclear.
Dietmar Enko +5 more
doaj +1 more source