Results 31 to 40 of about 1,908 (139)

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals

Scientific Reports, 2018
In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the −13910C > T, but also others, are ...
Milena N. Leseva, Richard J. Grand, Hagen Klett, Melanie Boerries, Hauke Busch, Alexandra M. Binder, Karin B. Michels   +6 more
doaj   +1 more source

Lactose intolerance and gastrointestinal cow’s milk allergy in infants and children – common misconceptions revisited

World Allergy Organization Journal, 2017
Lactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed.
Ralf G. Heine, Fawaz AlRefaee, Prashant Bachina, Julie C. De Leon, Lanlan Geng, Sitang Gong, José Armando Madrazo, Jarungchit Ngamphaiboon, Christina Ong, Jossie M. Rogacion   +9 more
doaj   +3 more sources

Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption. [PDF]

PLoS ONE, 2018
BACKGROUND:Current literature proposes associations between homocysteine (HCY), folic acid (FA), vitamin B12 metabolism and depression. However, the exact underlying biological mechanisms remain unclear.
Dietmar Enko, Andreas Meinitzer, Wolfgang Brandmayr, Gabriele Halwachs-Baumann, Wolfgang J Schnedl, Gernot Kriegshäuser   +5 more
doaj   +1 more source

Meta-analysis of lactase phenotypes on obesity, metabolic syndrome and milk consumption

BMJ Nutrition, Prevention & Health
Background The variability in lactose digestion ability is categorised into lactase persistence and lactase non-persistence phenotypes, primarily determined by the 13 910 C>T single nucleotide polymorphism (rs4988235).
Pornthep Tanpowpong, Sasivimol Rattanasiri, Karis Phengsalae, Songpon Getsuwan, Sirinapa Siwarom   +4 more
doaj   +1 more source

Evaluation of Milk and Lactose Sensitivity in Lactase Non-Persistence Genotypes

Proceedings, 2019
Background: Lactase non-persistence, a condition affecting 75% of the world’s population, ischaracterized by inactivity of the lactase enzyme, resulting in lactose intolerance. [...]
Aahana Shrestha, Jakob André Martinsson, Helga Josefin Karlström, Nils Jimmy Nilsson, Mathew Philip Greig Barnett, Jo Kate Perry, Amber Marie Milan, David Cameron-Smith   +7 more
doaj   +1 more source

Lactase non-persistent genotype influences milk consumption and gastrointestinal symptoms in Northern Russians

BMC Gastroenterology, 2011
Background Milk is an important source of nutrients. The consumption of milk, however, may cause abdominal complaints in lactose intolerant individuals.
Khabarova Yulia, Tornianen Suvi, Tuomisto Sari, Järvelä Irma, Karhunen Pekka, Isokoski Mauri, Mattila Kari   +6 more
doaj   +1 more source

Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms

BMC Gastroenterology, 2009
Background Oxytocin and the oxytocin receptor have been demonstrated in the gastrointestinal (GI) tract and have been shown to exert physiological effects on gut motility. The role for oxytocin in the pathophysiology of GI complaints is unknown.
Simrén Magnus, Carlson Joyce, Truedsson Mikael, Ohlsson Bodil   +3 more
doaj   +1 more source

Relation of the C/T-13910 LCT Polymorphism with Body Composition Measures and Their Modulation by Dairy Products in a Caucasian Men

American Journal of Men's Health, 2021
The C/T-13910 LCT is closely associated with lactase persistence and LCT has emerged as a new candidate gene for obesity, in particular in northern Europeans.
Agnieszka Popadowska, Agnieszka Kempinska-Podhorodecka   +1 more
doaj   +1 more source

Polymorphism of the LCT gene regulatory region in Turkicspeaking populations of the Altay-Sayan region (southern Siberia)

Вавиловский журнал генетики и селекции, 2017
Retention of lactase activity in adulthood (lactase persistence) is one of the most important adaptive traits for human populations that consume fresh milk from domestic animals.
I. V. Pilipenko, M. S. Pristyazhnyuk, V. F. Kobzev, M. I. Voevoda, A. S. Pilipenko   +4 more
doaj   +1 more source

Correlation between lactose absorption and the C/T-13910 and G/A-22018 mutations of the lactase-phlorizin hydrolase (LCT) gene in adult-type hypolactasia

Brazilian Journal of Medical and Biological Research, 2007
The C/T-13910 mutation is the major factor responsible for the persistence of the lactase-phlorizin hydrolase (LCT) gene expression. Mutation G/A-22018 appears to be only in co-segregation with C/T-13910.
A.C. Bulhões, H.A.S. Goldani, F.S. Oliveira, U.S. Matte, R.B. Mazzuca, T.R. Silveira   +5 more
doaj   +1 more source