Proposed mechanism for the selection of lactase persistence in childhood
BioEssays, 2023 International audienceAbstract Lactase persistence/persistent (LP), the ability to express the lactase enzyme in adults, is one of the most strongly selected phenotypes in humans.
Fabre, Alexandre +9 more
core +4 more sources
Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations [PDF]
Genetics and Molecular Biology, 2017 Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek +5 more
doaj +2 more sources
Evaluation of Milk and Lactose Sensitivity in Lactase Non-Persistence Genotypes
Proceedings, 2019 Background: Lactase non-persistence, a condition affecting 75% of the world’s population, ischaracterized by inactivity of the lactase enzyme, resulting in lactose intolerance. [...]
Aahana Shrestha +7 more
doaj +2 more sources
Diversity of lactase persistence in African milk drinkers [PDF]
Human Genetics, 2015 The genetic trait of lactase persistence is attributable to allelic variants in an enhancer region upstream of the lactase gene, LCT. To date, five different functional alleles, -13910*T, -13907*G, -13915*G, -14009*G and -14010*C, have been identified.
Dallas M Swallow +2 more
exaly +6 more sources
Lactase persistence and lipid pathway selection in the Maasai.
PLoS ONE, 2012 The Maasai are a pastoral people in Kenya and Tanzania, whose traditional diet of milk, blood and meat is rich in lactose, fat and cholesterol. In spite of this, they have low levels of blood cholesterol, and seldom suffer from gallstones or cardiac ...
Kshitij Wagh +12 more
doaj +4 more sources
Evolutionary GEM: Evolution of Lactase Persistence
Western Undergraduate Research Journal: Health and Natural Sciences, 2017 Though humans are known to lose lactase ability post-weaning, some people maintain lactase production into adulthood, a condition known as lactase persistence.
Gray, Patricia M. +3 more
core +3 more sources
Dairy Production and Lactase Persistence in Humans. [PDF]
Anim Front, 2023 europepmc +3 more sources
Dairying and the evolution and consequences of lactase persistence in humans. [PDF]
Anim Front, 2023 Stock JT, Wells JCK.
europepmc +4 more sources
Palaeoproteomic and genetic insights into millennial-scale dairy consumption in Armenia [PDF]
iScienceSummary: Dairy products are a key component of diet in Armenia today, yet the origins of milk consumption, its historical development, and genetic adaptations related to milk digestion remain understudied.
Mariya Antonosyan +30 more
doaj +2 more sources
Frequency of lactase persistence genotype in a healthy Polish population
Open Life Sciences, 2011 The majority of mammals are unable to digest lactose due to post-weaning deactivation of the LCT gene, which is responsible for encoding the enzyme lactase (i.e., adult-type hypolactasia).
Płoszaj Tomasz +2 more
doaj +2 more sources