Results 21 to 30 of about 1,908 (139)
Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population
Annals of Human Biology, 2022 Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase
Stefan Németh +5 more
doaj +1 more source
The molecular basis of lactase persistence: Linking genetics and epigenetics. [PDF]
Ann Hum GenetAbstractLactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Cohen CE, Swallow DM, Walker C.
europepmc +3 more sources
Human Genetics: Lactase Persistence in a Battlefield [PDF]
Current Biology, 2020 Lactase persistence is a common genetic trait in Europeans and other pastoralists. New ancient DNA evidence from a Bronze Age battlefield indicates that selection for lactase persistence was strong and on-going in the last 3,000 years.
openaire +3 more sources
The Onset of Lactase Persistence in Europe [PDF]
Human Heredity, 2013 The genomic region containing the lactase (LCT) gene shows one of the strongest signals of positive selection in Europeans, detectable using a range of approaches including haplotype length, linked microsatellite variation and population-differentiation-based tests. Lactase is the enzyme that carries out the digestion of the milk sugar lactose.
openaire +2 more sources
Diversity of lactase persistence in African milk drinkers. [PDF]
Hum Genet, 2015 The genetic trait of lactase persistence is attributable to allelic variants in an enhancer region upstream of the lactase gene, LCT. To date, five different functional alleles, -13910*T, -13907*G, -13915*G, -14009*G and -14010*C, have been identified.
Jones BL +10 more
europepmc +5 more sources
Documenta Praehistorica, 2013 The ability to digest milk during adulthood (lactase persistence) is a genetically determined trait present only in humans. Its origin and diffusion are correlated with the development of pastoralism and the consumption of fresh milk.
Michela Leonardi
doaj +1 more source
Proposed mechanism for the selection of lactase persistence in childhood
BioEssays, 2023 AbstractLactase persistence/persistent (LP), the ability to express the lactase enzyme in adults, is one of the most strongly selected phenotypes in humans. It is encoded by at least five genetic variants that have rapidly become widespread in various human populations.
Fabre, Alexandre +4 more
openaire +3 more sources
Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population. [PDF]
PLoS ONE, 2012 Adult-type hypolactasia is a common phenotype caused by the lactase enzyme deficiency. The -13910 C>T polymorphism, located 14 Kb upstream of the lactase gene (LCT) in the MCM6 gene was associated with lactase persistence (LP) in Europeans.
Deise C Friedrich +3 more
doaj +1 more source
BMC Research Notes, 2010 Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts.
Morgan Angharad R +6 more
doaj +1 more source
Genetic origins of lactase persistence and the spread of pastoralism in Africa. [PDF]
Am J Hum Genet, 2014 In humans, the ability to digest lactose, the sugar in milk, declines after weaning because of decreasing levels of the enzyme lactase-phlorizin hydrolase, encoded by LCT. However, some individuals maintain high enzyme amounts and are able to digest lactose into adulthood (i.e., they have the lactase-persistence [LP] trait).
Ranciaro A +10 more
europepmc +6 more sources