Results 21 to 30 of about 345,367 (170)

Proposed mechanism for the selection of lactase persistence in childhood

BioEssays, 2023
AbstractLactase persistence/persistent (LP), the ability to express the lactase enzyme in adults, is one of the most strongly selected phenotypes in humans. It is encoded by at least five genetic variants that have rapidly become widespread in various human populations.
Fabre, Alexandre, Fabre, Anne, Bon, Céline, Guerry, Paul, Ségurel, Laure   +4 more
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Lactase persistence and milk consumption in Europe: an interdisciplinary approach involving genetics and archaeology [PDF]

Documenta Praehistorica, 2013
The ability to digest milk during adulthood (lactase persistence) is a genetically determined trait present only in humans. Its origin and diffusion are correlated with the development of pastoralism and the consumption of fresh milk.
Michela Leonardi
doaj   +2 more sources

Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification [PDF]

Heliyon
The single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Almuthanna K. Alkaraki, Miguel A. Alfonso-Sánchez, Jose A. Peña, Alanoud I. Abuelezz   +3 more
doaj   +2 more sources

Diversity of lactase persistence in African milk drinkers [PDF]

Human Genetics, 2015
The genetic trait of lactase persistence is attributable to allelic variants in an enhancer region upstream of the lactase gene, LCT. To date, five different functional alleles, -13910*T, -13907*G, -13915*G, -14009*G and -14010*C, have been identified.
Jones, BL, Oljira, T, Liebert, A, Zmarz, P, Montalva, N, Tarekeyn, A, Ekong, R, Thomas, MG, Bekele, E, Bradman, N, Swallow, DM   +10 more
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Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations [PDF]

Genetics and Molecular Biology, 2017
Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek, Věra Adámková, Lenka Šedová, Věra Olišarová, Václav Adámek, Valérie Tóthová   +5 more
doaj   +2 more sources

Meta-analysis of lactase phenotypes on obesity, metabolic syndrome and milk consumption [PDF]

BMJ Nutrition, Prevention & Health
Background The variability in lactose digestion ability is categorised into lactase persistence and lactase non-persistence phenotypes, primarily determined by the 13 910 C>T single nucleotide polymorphism (rs4988235).
Pornthep Tanpowpong, Sasivimol Rattanasiri, Karis Phengsalae, Songpon Getsuwan, Sirinapa Siwarom   +4 more
doaj   +2 more sources

Evolutionary GEM: Evolution of Lactase Persistence

Western Undergraduate Research Journal: Health and Natural Sciences, 2017
Though humans are known to lose lactase ability post-weaning, some people maintain lactase production into adulthood, a condition known as lactase persistence. Global distribution patterns of lactase persistency are inconsistent; the condition is much more prevalent in some populations than others.
Xinghan (Hill) Du, Patricia M. Gray
openaire   +3 more sources

The molecular basis of lactase persistence: Linking genetics and epigenetics [PDF]

Annals of Human Genetics
AbstractLactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen, Dallas M. Swallow, Catherine Walker   +2 more
openaire   +3 more sources

Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]

PLoS Biology, 2020
The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Segurel, Perle Guarino-Vignon, Nina Marchi, Sophie Lafosse, Romain Laurent, Céline Bon, Alexandre Fabre, Tatyana Hegay, Evelyne Heyer   +8 more
doaj   +2 more sources

Genetic Origins of Lactase Persistence and the Spread of Pastoralism in Africa [PDF]

The American Journal of Human Genetics, 2014
In humans, the ability to digest lactose, the sugar in milk, declines after weaning because of decreasing levels of the enzyme lactase-phlorizin hydrolase, encoded by LCT. However, some individuals maintain high enzyme amounts and are able to digest lactose into adulthood (i.e., they have the lactase-persistence [LP] trait).
Ranciaro, Alessia, Campbell, Michael C., Hirbo, Jibril B., Ko, Wen Ya, Froment, Alain, ANAGNOSTOU, PAOLO, Kotze, Maritha J., Ibrahim, Muntaser, Nyambo, Thomas, Omar, Sabah A., Tishkoff, Sarah A.   +10 more
openaire   +5 more sources