Results 21 to 30 of about 5,485 (192)

The lactase persistence genotype is a protective factor for the metabolic syndrome [PDF]

Genetics and Molecular Biology, 2014
The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension.
Deise C. Friedrich, Fabiana M de Andrade, Marilu Fiegenbaum, Silvana de Almeida, Vanessa S. Mattevi, Sidia M. Callegari-Jacques, Mara H. Hutz   +6 more
doaj   +4 more sources

Strain-Level Analysis of Bifidobacterium spp. from Gut Microbiomes of Adults with Differing Lactase Persistence Genotypes [PDF]

mSystems, 2020
One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Victor Schmidt, Hagay Enav, Timothy D. Spector, Nicholas D. Youngblut, Ruth E. Ley   +4 more
doaj   +2 more sources

Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations [PDF]

Genetics and Molecular Biology, 2017
Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek, Věra Adámková, Lenka Šedová, Věra Olišarová, Václav Adámek, Valérie Tóthová   +5 more
doaj   +2 more sources

Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification [PDF]

Heliyon
The single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Almuthanna K. Alkaraki, Miguel A. Alfonso-Sánchez, Jose A. Peña, Alanoud I. Abuelezz   +3 more
doaj   +2 more sources

Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]

PLoS Biology, 2020
The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Segurel, Perle Guarino-Vignon, Nina Marchi, Sophie Lafosse, Romain Laurent, Céline Bon, Alexandre Fabre, Tatyana Hegay, Evelyne Heyer   +8 more
doaj   +2 more sources

The human lactase persistence-associated SNP −13910*T enables in vivo functional persistence of lactase promoter–reporter transgene expression [PDF]

Human Genetics, 2012
Lactase is the intestinal enzyme responsible for digestion of the milk sugar lactose. Lactase gene expression declines dramatically upon weaning in mammals and during early childhood in humans (lactase nonpersistence). In various ethnic groups, however, lactase persists in high levels throughout adulthood (lactase persistence).
Lin, Fang, Jong Kun, Ahn, Dariusz, Wodziak, Eric, Sibley   +3 more
openaire   +4 more sources

Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait [PDF]

BMC Genomics, 2019
Background Human population history in the Holocene was profoundly impacted by changes in lifestyle following the invention and adoption of food-production practices.
Mário Vicente, Edita Priehodová, Issa Diallo, Eliška Podgorná, Estella S. Poloni, Viktor Černý, Carina M. Schlebusch   +6 more
doaj   +2 more sources

Evolution of lactase persistence: an example of human niche construction [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
Niche construction is the process by which organisms construct important components of their local environment in ways that introduce novel selection pressures. Lactase persistence is one of the clearest examples of niche construction in humans. Lactase is the enzyme responsible for the digestion of the milk sugar lactose and its production decreases ...
Gerbault, P., Liebert, A., Itan, Y., Powell, A., Currat, Mathias, Burger, J., Swallow, D. M., Thomas, M. G.   +7 more
openaire   +6 more sources

Ileal Lactase Expression Associates with Lactase Persistence Genotypes. [PDF]

Nutrients, 2021
(1) Background: Lactose digestion depends on persistence genotypes (including rs4988235), the frequency of which exhibits broad geographical variability. However, little is known about the relationship between lactase (LCT) genotypes and intestinal expression of LCT.
Nowak JK, Dybska E, Dworacka M, Tsikhan N, Kononets V, Bermagambetova S, Walkowiak J.   +6 more
europepmc   +3 more sources

Preterm Birth International Collaborative Australasia Branch: Expert Consensus on Diagnosis and Treatment of Neonatal Lactose Intolerance (2025). [PDF]

Pediatr Discov
ABSTRACT This consensus aims to standardize the diagnosis and management of neonatal lactose intolerance (LI). A multidisciplinary working group was established under the auspices of the Preterm Birth International Collaborative (Australasia Branch). The development process included a comprehensive literature review of databases, which identified 61 ...
Wang Z, Han S, Lin X, Wu H, Xu L, Tang J, Hao W, Yu C, Tong X, Zhang J, Ju R, Xie X, Chen L, Li F, Zhu X, Xu L, Geng L, Zhou W, Ren X, Li C, Chen G, Tang W, Duan J, Zhao Z, Pan T, Li Z, Wu Y, Zhuang S, Ouyang Y, Xu F, Chen Z, Liu Y, Peng Z, Bao L, He Y, Kong L, Zheng X, Xu L, Shen Q, Zhang Q, Li J, Wang J, Shi Y.   +42 more
europepmc   +2 more sources