Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]
Frontiers in Physiology, 2021 The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Jonathan C. K. Wells +3 more
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Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas [PDF]
Frontiers in Genetics, 2021 In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Ana Cecília Guimarães Alves +55 more
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Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent [PDF]
Frontiers in Genetics, 2020 Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks
Shannon E. K. Joslin +9 more
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The lactase persistence genotype is a protective factor for the metabolic syndrome [PDF]
Genetics and Molecular Biology, 2014 The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension.
Deise C. Friedrich +6 more
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Strain-Level Analysis of
mSystems, 2020 One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Victor Schmidt +4 more
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Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations [PDF]
Genetics and Molecular Biology, 2017 Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek +5 more
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Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification [PDF]
HeliyonThe single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Almuthanna K. Alkaraki +3 more
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Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]
PLoS Biology, 2020 The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Segurel +8 more
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Lactase persistence and lipid pathway selection in the Maasai. [PDF]
PLoS ONE, 2012 The Maasai are a pastoral people in Kenya and Tanzania, whose traditional diet of milk, blood and meat is rich in lactose, fat and cholesterol. In spite of this, they have low levels of blood cholesterol, and seldom suffer from gallstones or cardiac ...
Kshitij Wagh +12 more
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Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait [PDF]
BMC Genomics, 2019 Background Human population history in the Holocene was profoundly impacted by changes in lifestyle following the invention and adoption of food-production practices.
Mário Vicente +6 more
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