The lactase persistence genotype is a protective factor for the metabolic syndrome [PDF]
Genetics and Molecular Biology, 2014 The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension.
Deise C. Friedrich +6 more
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Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas [PDF]
Frontiers in Genetics, 2021 In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Ana Cecília Guimarães Alves +55 more
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Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]
Frontiers in Physiology, 2021 The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Jonathan C. K. Wells +3 more
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Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent [PDF]
Frontiers in Genetics, 2020 Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks
Shannon E. K. Joslin +9 more
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Community based countrywide analysis of lactase persistence related genetic variants and their correlation with digestive symptoms in Libya. [PDF]
PLOS Global Public HealthLactose intolerance is a complex symptomatic response to lactose maldigestion that is influenced by, but not strictly determined by, the down- regulation of the enzyme lactase.
Ariej M Mustafa +7 more
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Strain-Level Analysis of
mSystems, 2020 One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Victor Schmidt +4 more
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Lactase persistence in the Jordanian population: Potential effects of the Arabian Peninsula and Sahara's aridification [PDF]
HeliyonThe single nucleotide polymorphism (SNP) −13910 C > T has proved a good predictor of the incidence of lactase persistence in Europe and South Asia.
Almuthanna K. Alkaraki +3 more
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Meta-analysis of lactase phenotypes on obesity, metabolic syndrome and milk consumption [PDF]
BMJ Nutrition, Prevention & HealthBackground The variability in lactose digestion ability is categorised into lactase persistence and lactase non-persistence phenotypes, primarily determined by the 13 910 C>T single nucleotide polymorphism (rs4988235).
Pornthep Tanpowpong +4 more
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Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]
PLoS Biology, 2020 The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Segurel +8 more
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Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait [PDF]
BMC Genomics, 2019 Background Human population history in the Holocene was profoundly impacted by changes in lifestyle following the invention and adoption of food-production practices.
Mário Vicente +6 more
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