Results 11 to 20 of about 345,367 (170)

Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]

Frontiers in Physiology, 2021
The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Jonathan C. K. Wells, Emma Pomeroy, Jay T. Stock, Jay T. Stock   +3 more
doaj   +9 more sources

Genetic diversity of lactase persistence in East African populations [PDF]

BMC Research Notes, 2016
The expression of lactase which digests lactose from milk in humans is generally lost after weaning, but selected mutations influencing the promoter of the lactase gene have spread into the human populations. This is considered a classical example of gene-culture co-evolution, and several studies suggested that the lactase gene has been under strong ...
Hassan, H.Y., Erp, A. van, Jaeger, M., Tahir, H., Oosting, M., Joosten, L.A., Netea, M.G.   +6 more
europepmc   +7 more sources

The Onset of Lactase Persistence in Europe [PDF]

Human Heredity, 2013
The genomic region containing the lactase (LCT) gene shows one of the strongest signals of positive selection in Europeans, detectable using a range of approaches including haplotype length, linked microsatellite variation and population-differentiation-based tests. Lactase is the enzyme that carries out the digestion of the milk sugar lactose.
Gerbault, P.
openaire   +3 more sources

Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas [PDF]

Frontiers in Genetics, 2021
In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Ana Cecília Guimarães Alves, Ana Cecília Guimarães Alves, Natalie Mary Sukow, Gabriel Adelman Cipolla, Marla Mendes, Thiago P. Leal, Maria Luiza Petzl-Erler, Maria Luiza Petzl-Erler, Ricardo Lehtonen Rodrigues Souza, Ricardo Lehtonen Rodrigues Souza, Ilíada Rainha de Souza, Ilíada Rainha de Souza, Cesar Sanchez, Meddly Santolalla, Douglas Loesch, Michael Dean, Moara Machado, Jee-Young Moon, Robert Kaplan, Robert Kaplan, Kari E. North, Scott Weiss, Mauricio L. Barreto, Mauricio L. Barreto, M. Fernanda Lima-Costa, M. Fernanda Lima-Costa, Heinner Guio, Heinner Guio, Omar Cáceres, Omar Cáceres, Carlos Padilla, Eduardo Tarazona-Santos, Ignacio F. Mata, Ignacio F. Mata, Ignacio F. Mata, Elena Dieguez, Víctor Raggio, Andres Lescano, Vitor Tumas, Vanderci Borges, Henrique B. Ferraz, Carlos R. Rieder, Artur Schumacher-Schuh, Artur Schumacher-Schuh, Bruno L. Santos-Lobato, Pedro Chana-Cuevas, William Fernandez, Gonzalo Arboleda, Humberto Arboleda, Carlos E. Arboleda-Bustos, Timothy D. O’Connor, Timothy D. O’Connor, Timothy D. O’Connor, Marcia Holsbach Beltrame, Marcia Holsbach Beltrame, Victor Borda   +55 more
doaj   +2 more sources

Human Genetics: Lactase Persistence in a Battlefield [PDF]

Current Biology, 2020
Lactase persistence is a common genetic trait in Europeans and other pastoralists. New ancient DNA evidence from a Bronze Age battlefield indicates that selection for lactase persistence was strong and on-going in the last 3,000 years.
Saag, L
core   +6 more sources

Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910) in medieval central europe. [PDF]

PLoS ONE, 2014
Ruminant milk and dairy products are important food resources in many European, African, and Middle Eastern societies. These regions are also associated with derived genetic variants for lactase persistence.
Annina Krüttli, Abigail Bouwman, Gülfirde Akgül, Philippe Della Casa, Frank Rühli, Christina Warinner   +5 more
doaj   +5 more sources

Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent [PDF]

Frontiers in Genetics, 2020
Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks
Shannon E. K. Joslin, Blythe P. Durbin-Johnson, Blythe P. Durbin-Johnson, Monica Britton, Matthew L. Settles, Ian Korf, Ian Korf, Danielle G. Lemay, Danielle G. Lemay, Danielle G. Lemay   +9 more
doaj   +2 more sources

Community based countrywide analysis of lactase persistence related genetic variants and their correlation with digestive symptoms in Libya. [PDF]

PLOS Global Public Health
Lactose intolerance is a complex symptomatic response to lactose maldigestion that is influenced by, but not strictly determined by, the down- regulation of the enzyme lactase.
Ariej M Mustafa, Inas M Alhudiri, Abdenaser A Mohamed, Hafsa Al-Emam, Ahmad Ramadan, Halla Elshwekh, Hamza Ben Zeglam, Nabil S Enattah   +7 more
doaj   +2 more sources

World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection. [PDF]

Hum Genet, 2017
The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G ...
Liebert A, López S, Jones BL, Montalva N, Gerbault P, Lau W, Thomas MG, Bradman N, Maniatis N, Swallow DM.   +9 more
europepmc   +2 more sources

Strain-Level Analysis of Bifidobacterium spp. from Gut Microbiomes of Adults with Differing Lactase Persistence Genotypes [PDF]

mSystems, 2020
One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Victor Schmidt, Hagay Enav, Timothy D. Spector, Nicholas D. Youngblut, Ruth E. Ley   +4 more
doaj   +2 more sources