Diversity of lactase persistence in African milk drinkers. [PDF]
Hum Genet, 2015 The genetic trait of lactase persistence is attributable to allelic variants in an enhancer region upstream of the lactase gene, LCT. To date, five different functional alleles, -13910*T, -13907*G, -13915*G, -14009*G and -14010*C, have been identified ...
Jones BL +10 more
europepmc +7 more sources
The origins of lactase persistence in Europe.
PLoS Computational Biology, 2009 Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world.
Yuval Itan +4 more
doaj +10 more sources
A worldwide correlation of lactase persistence phenotype and genotypes [PDF]
BMC Evolutionary Biology, 2010 Background The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Ingram Catherine JE +4 more
doaj +6 more sources
Lactase persistence and lipid pathway selection in the Maasai. [PDF]
PLoS ONE, 2012 The Maasai are a pastoral people in Kenya and Tanzania, whose traditional diet of milk, blood and meat is rich in lactose, fat and cholesterol. In spite of this, they have low levels of blood cholesterol, and seldom suffer from gallstones or cardiac ...
Kshitij Wagh +12 more
doaj +5 more sources
Evolution of Lactase Persistence: Turbo-Charging Adaptation in Growth Under the Selective Pressure of Maternal Mortality? [PDF]
Frontiers in Physiology, 2021 The emergence of the capacity to digest milk in some populations represents a landmark in human evolution, linking genetic change with a component of niche construction, namely dairying.
Jonathan C. K. Wells +3 more
doaj +2 more sources
Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas [PDF]
Frontiers in Genetics, 2021 In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads.
Ana Cecília Guimarães Alves +55 more
doaj +2 more sources
Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent [PDF]
Frontiers in Genetics, 2020 Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks
Shannon E. K. Joslin +9 more
doaj +2 more sources
Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups [PDF]
Nutrition Journal, 2009 Background Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa.
Silva Joyce MK +5 more
doaj +2 more sources
The evolution of lactase persistence [PDF]
Antropologia Portuguesa, 2012 Lactase persistence has long been recognized as a striking example of human dietary adaptation to changes in food production habits. The observation that the prevalence of lactase persistence is positively correlated with the cultural history of dairying
Jorge Rocha
doaj +3 more sources
World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection. [PDF]
Hum Genet, 2017 The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G ...
Liebert A +9 more
europepmc +7 more sources