Results 61 to 70 of about 1,930 (158)

Lactase Persistence Variants in Arabia and in the African Arabs

Human Biology, 2014
Lactase persistence (LP), the state enabling the digestion of milk sugar in adulthood, occurs only in some human populations. The convergent and independent origin of this physiological ability in Europe and Africa is linked with animal domestication that either had started in both places independently or had spread from the Near East by acculturation.
Edita, Priehodová, Abdelhay, Abdelsawy, Evelyne, Heyer, Viktor, Cerný   +3 more
openaire   +3 more sources

Convergent adaptation of human lactase persistence in Africa and Europe [PDF]

Nature Genetics, 2006
A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Tanzanians, Kenyans and Sudanese and identified three SNPs (G/C-14010,
Tishkoff SA, Reed FA, Ranciaro, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen, HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema, G, Nyambo TB, Ghori J, Bumpstead, S, Pritchard, JK, Wray GA, Deloukas P   +23 more
openaire   +3 more sources

Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau

BMC Biology, 2023
Background Domestication and introduction of dairy animals facilitated the permanent human occupation of the Tibetan Plateau. Yet the history of dairy pastoralism in the Tibetan Plateau remains poorly understood.
Min-Sheng Peng, Yan-Hu Liu, Quan-Kuan Shen, Xiao-Hua Zhang, Jiajia Dong, Jin-Xiu Li, Hui Zhao, Hui Zhang, Xiaoming Zhang, Yaoxi He, Hong Shi, Chaoying Cui, Ouzhuluobu, Tian-Yi Wu, Shi-Ming Liu, Gonggalanzi, Baimakangzhuo, Caijuan Bai, Duojizhuoma, Ti Liu, Shan-Shan Dai, Robert W. Murphy, Xue-Bin Qi, Guanghui Dong, Bing Su, Ya-Ping Zhang   +25 more
doaj   +1 more source

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

International Journal of Dermatology, Volume 65, Issue 4, Page 706-723, April 2026.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska, Isha Gandhi, Robert Adler, Deena Fayyad, Perya Bhagchandani, Shabnam Afzal, Waleed Adawi, Shivani Patel, Shawn G. Kwatra   +8 more
wiley   +1 more source

Lack of Association between LCT_rs140433552*CA>del Indel Polymorphism and Lactose Intolerance in a Southern Brazilian Population

Lifestyle Genomics, 2020
Background/Aims: Polymorphisms in the enhancer of the lactase gene (LCT) are strongly associated with lactase persistence, but not always predictive of the phenotype.
Luana Caroline Oliveira, Andrey Lucas Dias Barros, Angelica Beate Winter Boldt, Gabriel Adelman Cipolla   +3 more
doaj   +1 more source

Molecular Pharming: Advances, Applications, and Future Prospects in Biotechnology and Medicine

Engineering in Life Sciences, Volume 26, Issue 3, March 2026.
ABSTRACT Genetically engineered plants incorporate the use of a novel bioreactor known as molecular pharming, which has a transformative view on the pharmaceutical industry. The technique enables mass production, at a low cost, and reproducibly of a large number of different protein‐based drugs, vaccines, and industrial enzymes. This review‐based study
Md. Hridoy Ahmed, Md. Mustak Khan, Shishir Dutta, Md. Foyzur Rahman, Mohammad Shariful Islam, Md. Najmul Hosen, Md. Saad Hossain, Md. Aftabur Rahman, Md. Sadman Hasan Sahil, Tanjuma Tasnim Hira, Ifthesum, Ashikur Rahaman, Md. Afser Rabbi, Laila Khaleda   +13 more
wiley   +1 more source

Preterm Birth International Collaborative Australasia Branch: Expert Consensus on Diagnosis and Treatment of Neonatal Lactose Intolerance (2025)

Pediatric Discovery, Volume 4, Issue 1, March 2026.
ABSTRACT This consensus aims to standardize the diagnosis and management of neonatal lactose intolerance (LI). A multidisciplinary working group was established under the auspices of the Preterm Birth International Collaborative (Australasia Branch). The development process included a comprehensive literature review of databases, which identified 61 ...
Zhengli Wang, Shuping Han, Xinzhu Lin, Hui Wu, Lingfen Xu, Jun Tang, Wei Hao, Chao Yu, Xiaomei Tong, Juan Zhang, Rong Ju, Xiaoli Xie, Long Chen, Fang Li, Xingwang Zhu, Liping Xu, Lanlan Geng, Wei Zhou, Xueyun Ren, Chuanfeng Li, Guoping Chen, Wenyan Tang, Jiang Duan, Zhi Zhao, Tao Pan, Zhongliang Li, Yingli Wu, Siqi Zhuang, Ying Ouyang, Falin Xu, Zheng Chen, Yiyang Liu, Zhoujie Peng, Lei Bao, Yu He, Lin Kong, Xianlan Zheng, Lijuan Xu, Qiao Shen, Qian Zhang, Junli Li, Junjun Wang, Yuan Shi   +42 more
wiley   +1 more source

European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow‐Up, and Complex Disease Courses

United European Gastroenterology Journal, Volume 14, Issue 2, March 2026.
ABSTRACT Introduction Since the publication of the first European Society for the Study of Coeliac Disease (ESsCD) guidelines in 2019, substantial advances have been made in understanding the management and complex disease courses of coeliac disease (CeD) in adults.
Abdulbaqi Al‐Toma, Federica Branchi, Fabiana Zingone, Annalisa Schiepatti, Georgia Malamut, Cristina Canova, Isabella Rosato, Honoria Ocagli, Nick Trott, Luca Elli, Alina Popp, Carmen Gianfrani, Renata Auricchio, Andra Neefjes‐Borst, David S. Sanders, Christophe Cellier, Chris J. Mulder, Gerd Bouma, Knut E. A. Lundin, Ludvig M. Sollid, Michael Schumann   +20 more
wiley   +1 more source

High frequency of lactose intolerance in a prehistoric hunter-gatherer population in northern Europe

BMC Evolutionary Biology, 2010
Background Genes and culture are believed to interact, but it has been difficult to find direct evidence for the process. One candidate example that has been put forward is lactase persistence in adulthood, i.e. the ability to continue digesting the milk
Holmlund Gunilla, Molnar Petra, Storå Jan, Lidén Kerstin, Linderholm Anna, Malmström Helena, Jakobsson Mattias, Götherström Anders   +7 more
doaj   +1 more source

Lactose‐Derived Carbohydrates Induce Sexually Dimorphic Nutritional Programming Effects on Lifespan in Drosophila melanogaster

Aging Cell, Volume 25, Issue 3, March 2026.
Early‐life co‐consumption of galactose and glucose (hydrolyzed lactose) programs Drosophila melanogaster lifespan in a sex‐specific manner. Particularly, the co‐consumption of galactose and glucose programs extended lifespan when female flies were challenged by obesogenic diets later in life, and this is concomitant with remodeling of lipid metabolism,
Peixin Sun, Shiying Shao, Robin W. Creemers, Anna F. Bekebrede, Jing Tang, Steven Driever, Jaap Keijer, Evert M. van Schothorst   +7 more
wiley   +1 more source