The Origins of Lactase Persistence in Europe
PLoS Computational Biology, 2009 Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world.
Yuval Itan, Mark G Thomas
exaly +12 more sources
Dairying, diseases and the evolution of lactase persistence in Europe [PDF]
Nature, 2022 In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years1. Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal ...
Richard P Evershed +2 more
exaly +12 more sources
Dairy Production and Lactase Persistence in Humans. [PDF]
Anim Front, 2023 europepmc +6 more sources
A worldwide correlation of lactase persistence phenotype and genotypes [PDF]
BMC Evolutionary Biology, 2010 Background The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Ingram Catherine JE +4 more
doaj +10 more sources
Ileal Lactase Expression Associates with Lactase Persistence Genotypes. [PDF]
Nutrients, 2021 (1) Background: Lactose digestion depends on persistence genotypes (including rs4988235), the frequency of which exhibits broad geographical variability.
Nowak JK +6 more
europepmc +5 more sources
The evolution of lactase persistence [PDF]
Antropologia Portuguesa, 2012 Lactase persistence has long been recognized as a striking example of human dietary adaptation to changes in food production habits. The observation that the prevalence of lactase persistence is positively correlated with the cultural history of dairying
Jorge Rocha
doaj +7 more sources
Impact of selection and demography on the diffusion of lactase persistence. [PDF]
PLoS ONE, 2009 BACKGROUND:The lactase enzyme allows lactose digestion in fresh milk. Its activity strongly decreases after the weaning phase in most humans, but persists at a high frequency in Europe and some nomadic populations.
Pascale Gerbault +3 more
doaj +20 more sources
The Genetic Variation of Lactase Persistence Alleles in Sudan and South Sudan. [PDF]
Genome Biol Evol, 2021 Lactase persistence (LP) is a well-studied example of a Mendelian trait under selection in some human groups due to gene-culture coevolution. We investigated the frequencies of genetic variants linked to LP in Sudanese and South Sudanese populations ...
Hollfelder N +4 more
europepmc +8 more sources
World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection [PDF]
Human Genetics, 2017 The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G ...
Anke Liebert, Saioa López, Winston Lau
exaly +9 more sources
Strain-Level Analysis of
mSystems, 2020 One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Victor Schmidt +4 more
doaj +3 more sources