Lactase persistence and lipid pathway selection in the Maasai. [PDF]
PLoS ONE, 2012 The Maasai are a pastoral people in Kenya and Tanzania, whose traditional diet of milk, blood and meat is rich in lactose, fat and cholesterol. In spite of this, they have low levels of blood cholesterol, and seldom suffer from gallstones or cardiac ...
Kshitij Wagh +12 more
doaj +6 more sources
Ileal Lactase Expression Associates with Lactase Persistence Genotypes. [PDF]
Nutrients, 2021 (1) Background: Lactose digestion depends on persistence genotypes (including rs4988235), the frequency of which exhibits broad geographical variability.
Nowak JK +6 more
europepmc +4 more sources
Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Dogs. [PDF]
Mol Biol Evol, 2021 Coexistence and cooperation between dogs and humans over thousands of years have supported convergent evolutionary processes in the two species. Previous studies found that Eurasian dogs evolved into a distinct geographic cluster.
Liu YH +8 more
europepmc +4 more sources
The Origins of Lactase Persistence in Europe
PLoS Computational Biology, 2009 Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world.
Yuval Itan, Mark G Thomas
exaly +10 more sources
Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations [PDF]
Genetics and Molecular Biology, 2017 Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek +5 more
doaj +4 more sources
Dairying, diseases and the evolution of lactase persistence in Europe [PDF]
Nature, 2022 Richard P Evershed +2 more
exaly +3 more sources
Strain-Level Analysis of
mSystems, 2020 One of the strongest associations between human genetics and the gut microbiome is a greater relative abundance of Bifidobacterium in adults with lactase gene (LCT) single nucleotide polymorphisms (SNPs) associated with lactase nonpersistence (GG ...
Victor Schmidt +4 more
doaj +3 more sources
Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA. [PDF]
PLoS Biology, 2020 The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent human evolution. While the phenotypic change under selection, lactase persistence (LP), is known, the evolutionary advantage ...
Laure Segurel +8 more
doaj +3 more sources
Diversity of lactase persistence in African milk drinkers. [PDF]
Hum Genet, 2015 The genetic trait of lactase persistence is attributable to allelic variants in an enhancer region upstream of the lactase gene, LCT. To date, five different functional alleles, -13910*T, -13907*G, -13915*G, -14009*G and -14010*C, have been identified ...
Jones BL +10 more
europepmc +7 more sources
Dairy Production and Lactase Persistence in Humans. [PDF]
Anim Front, 2023 europepmc +4 more sources