The lactase persistence genotype is a protective factor for the metabolic syndrome [PDF]
Genetics and Molecular Biology, 2014 The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension.
Deise C. Friedrich +6 more
doaj +9 more sources
Diversity of lactase persistence in African milk drinkers. [PDF]
Hum Genet, 2015 The genetic trait of lactase persistence is attributable to allelic variants in an enhancer region upstream of the lactase gene, LCT. To date, five different functional alleles, -13910*T, -13907*G, -13915*G, -14009*G and -14010*C, have been identified ...
Jones BL +10 more
europepmc +7 more sources
Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations [PDF]
Genetics and Molecular Biology, 2017 Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression ...
Jaroslav A. Hubácek +5 more
doaj +4 more sources
Lactase persistence and lipid pathway selection in the Maasai. [PDF]
PLoS ONE, 2012 The Maasai are a pastoral people in Kenya and Tanzania, whose traditional diet of milk, blood and meat is rich in lactose, fat and cholesterol. In spite of this, they have low levels of blood cholesterol, and seldom suffer from gallstones or cardiac ...
Kshitij Wagh +12 more
doaj +6 more sources
Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait [PDF]
BMC Genomics, 2019 Background Human population history in the Holocene was profoundly impacted by changes in lifestyle following the invention and adoption of food-production practices.
Mário Vicente +6 more
doaj +3 more sources
Milk intake, lactase persistence genotype, plasma proteins and risks of cardiovascular events in the Swedish general population. [PDF]
Eur J Epidemiol, 2023 To investigate the associations of milk intake (non-fermented and fermented milk), lactase persistence ( LCT -13910 C/T) genotype (a proxy for long-term non-fermented milk intake), and gene-milk interaction with risks of cardiovascular disease (CVD) and ...
Zhang S +6 more
europepmc +2 more sources
Opinion: Increased calorie gain from lactose digestion could contribute to selection for lactase persistence. [PDF]
PLoS Genet, 2023 Lactase persistence refers to the retained ability of adults to express the gene for lactase and is recognised to be common in human populations which use domesticated animals.
Curtis D.
europepmc +2 more sources
Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden. [PDF]
Front Nutr, 2021 Background: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed.
Sonestedt E +3 more
europepmc +2 more sources
Human adaptation, demography and cattle domestication: an overview of the complexity of lactase persistence in Africa [PDF]
Human Molecular Genetics, 2021 Lactase persistence is a genetically-determined trait that is prevalent in African, European and Arab populations with a tradition of cattle herding and milk consumption.
Michael C. Campbell, Alessia Ranciaro
openalex +2 more sources
Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Dogs. [PDF]
Mol Biol Evol, 2021 Coexistence and cooperation between dogs and humans over thousands of years have supported convergent evolutionary processes in the two species. Previous studies found that Eurasian dogs evolved into a distinct geographic cluster.
Liu YH +8 more
europepmc +2 more sources