Opinion: Increased calorie gain from lactose digestion could contribute to selection for lactase persistence. [PDF]
PLoS Genet, 2023 Lactase persistence refers to the retained ability of adults to express the gene for lactase and is recognised to be common in human populations which use domesticated animals.
Curtis D.
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Dairying and the evolution and consequences of lactase persistence in humans. [PDF]
Anim Front, 2023 A stable and consistent food source is one of the most important evolutionary challenges facing any species. Mammalian young are typically born incapable of provisioning for themselves, but all mammalian species, through the production of milk, have ...
Stock JT, Wells JCK.
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Dairy Consumption, Lactase Persistence, and Mortality Risk in a Cohort From Southern Sweden. [PDF]
Front Nutr, 2021 Background: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed.
Sonestedt E +3 more
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Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910) in medieval central europe. [PDF]
PLoS ONE, 2014 Ruminant milk and dairy products are important food resources in many European, African, and Middle Eastern societies. These regions are also associated with derived genetic variants for lactase persistence.
Annina Krüttli +5 more
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Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population [PDF]
BMC Research Notes, 2010 Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts.
Morgan Angharad R +6 more
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The Genetic Variation of Lactase Persistence Alleles in Sudan and South Sudan. [PDF]
Genome Biol Evol, 2021 Lactase persistence (LP) is a well-studied example of a Mendelian trait under selection in some human groups due to gene-culture coevolution. We investigated the frequencies of genetic variants linked to LP in Sudanese and South Sudanese populations ...
Hollfelder N +4 more
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Development of a novel SNP assay to detect lactase persistence associated genetic variants. [PDF]
Mol Biol Rep, 2021 In adulthood the activity of the lactase enzyme is inherited as autosomal dominant form associated to Single nucleotide polymorphisms (SNPs). The present research was aimed to develop a novel genetic method to test lactase non persistence more powerfully.
De Luca P +10 more
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Neanderthal adaptive introgression shaped <i>LCT</i> enhancer region diversity without linking to lactase persistence in East Asian populations. [PDF]
Proc Natl Acad Sci U S ASignificance Positive selection at the 2q21.3 locus in Europeans and Africans has long been tied to lactase persistence (LP) and milk-drinking and is a textbook example of convergent evolution and gene–culture coevolution.
Ma X, Lu Y, Stoneking M, Xu S.
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Lactase Persistence-Associated rs4988235 Polymorphism: A Novel Genetic Link to Cardiovascular Risk via Modulation of ApoB100 and ApoAI. [PDF]
NutrientsBackground/Objectives: As part of the human adaptation to dairy consumption, the presence of the rs4988235-T variant in the MCM6 gene primarily determines lactase persistence in adult European populations, increasing the expression of the lactase ...
Kharrat Helu N +4 more
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The evolution of lactase persistence [PDF]
Antropologia Portuguesa, 2012 Lactase persistence has long been recognized as a striking example of human dietary adaptation to changes in food production habits. The observation that the prevalence of lactase persistence is positively correlated with the cultural history of dairying
Jorge Rocha
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