Diagnosis of adult-type hypolactasia/lactase persistence: genotyping of single nucleotide polymorphism (SNP C/T-13910) is not consistent with breath test in Colombian Caribbean population [PDF]
Arquivos de Gastroenterologia, 2012 CONTEXT: Genotyping of single nucleotide polymorphism (SNP C/T-13910) located upstream of the lactase gene is used to determine adult-type hypolactasia/lactase persistence in North-European Caucasian subjects.
Evelyn Mendoza Torres +3 more
doaj +2 more sources
The lactase persistence genotype is a protective factor for the metabolic syndrome [PDF]
Genetics and Molecular Biology, 2014 The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension.
Deise C. Friedrich +6 more
doaj +4 more sources
In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence [PDF]
, 2016 The genetic trait that allows intestinal lactase to persist into adulthood in some 35% of humans worldwide operates at the level of transcription, the effect being caused by cis-acting nucleotide changes upstream of the lactase gene (LCT).
Danielsen, ET +5 more
core +4 more sources
Impact of selection and demography on the diffusion of lactase persistence. [PDF]
PLoS ONE, 2009 BACKGROUND:The lactase enzyme allows lactose digestion in fresh milk. Its activity strongly decreases after the weaning phase in most humans, but persists at a high frequency in Europe and some nomadic populations.
Pascale Gerbault +3 more
doaj +3 more sources
Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population
Annals of Human Biology, 2022 Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase
Stefan Németh +5 more
doaj +2 more sources
Documenta Praehistorica, 2013 The ability to digest milk during adulthood (lactase persistence) is a genetically determined trait present only in humans. Its origin and diffusion are correlated with the development of pastoralism and the consumption of fresh milk.
Michela Leonardi
doaj +3 more sources
Genetic diversity of lactase persistence in East African populations. [PDF]
BMC Res Notes, 2016 The expression of lactase which digests lactose from milk in humans is generally lost after weaning, but selected mutations influencing the promoter of the lactase gene have spread into the human populations. This is considered a classical example of gene-culture co-evolution, and several studies suggested that the lactase gene has been under strong ...
Hassan HY +6 more
europepmc +8 more sources
The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults [PDF]
Oman Medical Journal, 2013 Objective: To examine the correlation of lactase persistence phenotype with genotype in Omani adults.Methods: Lactase persistence phenotype was tested by hydrogen breath test in 52 Omani Adults using the Micro H2 analyzer.
Abdulrahim Al-Abri, Riad Bayoumi
doaj +2 more sources
Nutrition Journal, 2009 Background Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa.
Silva Joyce MK +5 more
doaj +2 more sources
Annals of Human Genetics, 1998 A genetic polymorphism is responsible for determining that some humans express lactase at high levels throughout their lives and are thus lactose tolerant, while others lose lactase expression during childhood and are lactose intolerant. We have previously shown that this polymorphism is controlled by an element or elements which act in cis to the ...
C. Harvey +11 more
openalex +6 more sources