Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population
Annals of Human Biology, 2022 Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase
Stefan Németh +5 more
doaj +2 more sources
Proposed mechanism for the selection of lactase persistence in childhood
BioEssays, 2023 Lactase persistence/persistent (LP), the ability to express the lactase enzyme in adults, is one of the most strongly selected phenotypes in humans. It is encoded by at least five genetic variants that have rapidly become widespread in various human ...
A. Fabre +4 more
semanticscholar +4 more sources
Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana [PDF]
BMC Genetics, 2009 Background Lactase non-persistence is a condition where lactase activity is decreased in the intestinal wall after weaning. In European derived populations a single nucleotide polymorphism (SNP) C/T-13910 residing 13.9 kb upstream from the lactase gene ...
Dandara Collet +5 more
doaj +2 more sources
Genetic Origins of Lactase Persistence and the Spread of Pastoralism in Africa [PDF]
American Journal of Human Genetics, 2014 In humans, the ability to digest lactose, the sugar in milk, declines after weaning because of decreasing levels of the enzyme lactase-phlorizin hydrolase, encoded by LCT. However, some individuals maintain high enzyme amounts and are able to digest lactose into adulthood (i.e., they have the lactase-persistence [LP] trait).
Alessia Ranciaro +2 more
exaly +8 more sources
Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population [PDF]
BMC Research Notes, 2010 Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts.
Morgan Angharad R +6 more
doaj +2 more sources
Lactase persistence genotypes and malaria susceptibility in Fulani of Mali [PDF]
Malaria Journal, 2011 Background Fulani are a widely spread African ethnic group characterized by lower susceptibility to Plasmodium falciparum, clinical malaria morbidity and higher rate of lactase persistence compared to sympatric tribes.
Dolo Amagana +8 more
doaj +5 more sources
Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups [PDF]
Nutrition Journal, 2009 Background Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa.
Silva Joyce MK +5 more
doaj +2 more sources
Evaluation of Milk and Lactose Sensitivity in Lactase Non-Persistence Genotypes [PDF]
Proceedings, 2019 Background: Lactase non-persistence, a condition affecting 75% of the world’s population, ischaracterized by inactivity of the lactase enzyme, resulting in lactose intolerance. [...]
Aahana Shrestha +7 more
doaj +2 more sources
Comparison of Quick Lactose Intolerance Test in duodenal biopsies of dyspeptic patients with single nucleotide polymorphism LCT-13910C>T associated with primary hypolactasia/lactase-persistence [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To analyze the usefulness of Quick Lactose Intolerance Test in relation to the genetic test based on LCT-13910C>T genotypes, previously validated for clinical practice, for primary hypolactasia/lactase-persistence diagnosis.
Rejane Mattar +3 more
doaj +3 more sources
The Eurasian lactase persistence variant LCT-13910 C/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to sunlight. [PDF]
J Nutr Sci, 2020 Rapid selection of a genetic variant that confers continuous life-long lactase production in Europeans (LCT-13910 C/T) has been attributed to the advantages of acquiring nutrients from consuming milk without the disadvantages of lactose malabsorption ...
Moghaddam A.
europepmc +2 more sources