Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change [PDF]
, 2016 The importance of subtle gene regulation and epigenetics in determining complex human traits is increasingly being recognized. However, bridging the gaps between environmental, epigenetic and genetic influences and unraveling causal relationships remain ...
Swallow, DM, Troelsen, JT
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Association of the rs4988235 in the lactase gene with obesity and its modulation by dairy products in a Mediterranean population [PDF]
, 2011 The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association of this polymorphism with obesity-
Arregui, María +9 more
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Archives of Medical Science, 2022 The LCT: -13910C>T (rs4988235) polymorphism is associated with lactase persistence. Our previous study revealed impairment of pancreatic beta-cell function after an oral glucose tolerance test (OGTT) without a significant decrease in insulin sensitivity ...
M. Pietrzak-Nowacka +5 more
semanticscholar +1 more source
Measuring lactase enzymatic activity in the teaching lab [PDF]
, 2018 Understanding how enzymes work, and relating this to real life examples, is critical to a wide range of undergraduate degrees in the biological and biomedical sciences.
Cottrell, Graeme +5 more
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Evolution of the human fear-circuitry and acute sociogenic pseudoneurological symptoms: The Neolithic balanced-polymorphism hypothesis [PDF]
, 2005 In light of the increasing threat of large-scale massacres such as terrorism against non-combatants (civilians), more attention is warranted not only to posttraumatic stress disorder (PTSD) but also to acute sociogenic pseudoneurological ("conversion ...
Bracha, Dr. H. Stefan +3 more
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Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. [PDF]
Evol AnthropolABSTRACT Gene‐culture coevolution (GCC)—an ambitious synthesis of biological and social sciences is often used to explain the evolution of key human traits. Despite the framework's broad conceptual appeal however, empirical evidence is often perceived as limited to a few key examples like lactase persistence.
Kasser SM +3 more
europepmc +2 more sources
Modulation of lactose synthesis and orexinergic-glucose pathway by sex steroid hormones. [PDF]
Physiol RepAbstract Sex steroid hormones play a regulatory role in various metabolic processes, including glucose homeostasis via the orexinergic system and lactose synthesis. This review consolidates experimental findings on the mechanisms by which these hormones regulate these two pathways. A systematic search of PubMed, Scopus, and Web of Science identified 15
Hakizimana JC, Alagbonsi AI.
europepmc +2 more sources
Association of lactase persistence genotype with milk consumption, obesity and blood pressure:a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort with a systematic review and meta-analysis. [PDF]
, 2016 Background: Milk intake has been associated with lower blood pressure (BP) in observational studies, and randomized controlled trials suggested that milk-derived tripeptides have BP-lowering effects.
Davey Smith, George +4 more
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The Onset of Lactase Persistence in Europe [PDF]
Human Heredity, 2013 The genomic region containing the lactase (LCT) gene shows one of the strongest signals of positive selection in Europeans, detectable using a range of approaches including haplotype length, linked microsatellite variation and population-differentiation-based tests. Lactase is the enzyme that carries out the digestion of the milk sugar lactose.
openaire +2 more sources
Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population. [PDF]
PLoS ONE, 2012 Adult-type hypolactasia is a common phenotype caused by the lactase enzyme deficiency. The -13910 C>T polymorphism, located 14 Kb upstream of the lactase gene (LCT) in the MCM6 gene was associated with lactase persistence (LP) in Europeans.
Deise C Friedrich +3 more
doaj +1 more source