The Onset of Lactase Persistence in Europe [PDF]
Human Heredity, 2013 The genomic region containing the lactase (LCT) gene shows one of the strongest signals of positive selection in Europeans, detectable using a range of approaches including haplotype length, linked microsatellite variation and population-differentiation-based tests. Lactase is the enzyme that carries out the digestion of the milk sugar lactose.
Pascale Gerbault
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Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910) in medieval central europe. [PDF]
PLoS ONE, 2014 Ruminant milk and dairy products are important food resources in many European, African, and Middle Eastern societies. These regions are also associated with derived genetic variants for lactase persistence.
Annina Krüttli +5 more
doaj +1 more source
Lactase persistence, allelic asociation, and possible heterogeneity
Gastroenterology, 2003 Mark Poulter +8 more
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Archives of Medical Science, 2022 The LCT: -13910C>T (rs4988235) polymorphism is associated with lactase persistence. Our previous study revealed impairment of pancreatic beta-cell function after an oral glucose tolerance test (OGTT) without a significant decrease in insulin sensitivity ...
M. Pietrzak-Nowacka +5 more
semanticscholar +1 more source
Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. [PDF]
Evol AnthropolABSTRACT Gene‐culture coevolution (GCC)—an ambitious synthesis of biological and social sciences is often used to explain the evolution of key human traits. Despite the framework's broad conceptual appeal however, empirical evidence is often perceived as limited to a few key examples like lactase persistence.
Kasser SM +3 more
europepmc +2 more sources
Comparative metabolomics in primates reveals the effects of diet and gene regulatory variation on metabolic divergence. [PDF]
, 2014 Human diets differ from those of non-human primates. Among few obvious differences, humans consume more meat than most non-human primates and regularly cook their food.
Blekhman, Ran +5 more
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Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change [PDF]
, 2016 The importance of subtle gene regulation and epigenetics in determining complex human traits is increasingly being recognized. However, bridging the gaps between environmental, epigenetic and genetic influences and unraveling causal relationships remain ...
Swallow, DM, Troelsen, JT
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Lactase persistence: a case of evolution in modern humans [PDF]
The Biochemist, 2015 We modern humans may be able to control our environment and protect ourselves from the adverse consequences of disease, but our evolution never stops. The selective pressures that affect the numbers of viable offspring carrying novel DNA changes alter in time and space.
Dallas M. Swallow
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Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder. [PDF]
, 2006 The DSM-III, DSM-IV, DSM-IV-TR and ICD-10 have judiciously minimized discussion of etiologies to distance clinical psychiatry from Freudian psychoanalysis.
Bracha, Dr. H. Stefan
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