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Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
Frontiers in Oncology, 2019 Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts of glucose producing large volumes of lactate even in the presence of ...
Alejandro García-carranc +1 more
exaly +2 more sources
Frontiers in Oncology, 2021 Lactate has been observed to fuel TCA cycle and is associated with cancer progression in human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate on lung cancer metabolism is rarely reported.
Jun Jiang +12 more
doaj +2 more sources
Lactate Is a Metabolic Mediator That Shapes Immune Cell Fate and Function
Frontiers in Physiology, 2021 Lactate and the associated H+ ions are still introduced in many biochemistry and general biology textbooks and courses as a metabolic by-product within fast or oxygen-independent glycolysis.
Heather L. Caslin +5 more
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Frontiers in Immunology, 2020 Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7
Min Fan, Tuanzhu Ha, Chuanfu Li
exaly +2 more sources
Glucose feeds the TCA cycle via circulating lactate
Nature, 2017 Sheng Hui +2 more
exaly +2 more sources
Lactate Metabolism in Human Lung Tumors
Cell, 2017 Brandon Faubert, Ling Cai, Jiyeon Kim
exaly +2 more sources
Science Advances, 2023 High levels of lactate are positively associated with the prognosis and mortality in patients with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in cardiac fibrosis.
Min Fan +9 more
semanticscholar +1 more source
Cell Proliferation, 2023 Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the role of a universal metabolic fuel for energy via the ‘lactate shuttle’ moving between cells and transmitting signals.
Tingxi Wang +10 more
semanticscholar +1 more source
Lactate metabolism in human health and disease
Signal Transduction and Targeted Therapy, 2022 The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect.
Xiaolu Li +9 more
semanticscholar +1 more source
Clinical observations of Leber hereditary optic neuropathy with and without neurological symptoms [PDF]
Анналы клинической и экспериментальной неврологии, 2022 Three case studies of adults with Leber hereditary optic neuropathy with and without neurological symptoms are presented. An elevated blood lactate level and changes in the activity of the mitochondrial enzymes in peripheral blood lymphocytes were noted.
Sergey V. Kotov +4 more
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