Results 1 to 10 of about 774,319 (342)

LDH-A Promotes Metabolic Rewiring in Leucocytes from the Intestine of Rats Treated with TNBS

Metabolites, 2023
Although the aetiology of inflammatory bowel diseases (IBDs) is still unknown, one of their main characteristics is that the immune system chronically affects the permeability of the intestinal lamina propria, in turn altering the composition of the ...
Belen Mendoza-Arroyo, Martha Cecilia Rosales-Hernández, Judith Pacheco-Yépez, Astrid Mayleth Rivera-Antonio, Yazmín Karina Márquez-Flores, Luz María Cárdenas-Jaramillo, Aldo Arturo Reséndiz-Albor, Ivonne Maciel Arciniega-Martínez, Teresita Rocío Cruz-Hernández, Edgar Abarca-Rojano   +9 more
doaj   +1 more source

Evaluation of intermittent protocol at incremental laboratory test in measuring physiological indices of soccer players [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Purpose: Due to the intervals' nature of soccer, the aim of this study was to evaluate intermittent protocol of incremental laboratory test in measuring the physiological parameters of soccer players.Methods: Eighteen young soccer players (Mean ± SD; age
Atta Bahreini Nejad, ِDariush Moflahi, Mehdi Abbaspour   +2 more
doaj   +1 more source

Unveiling the veil of lactate in tumor-associated macrophages: a successful strategy for immunometabolic therapy

Frontiers in Immunology, 2023
Lactate, traditionally regarded as a metabolic waste product at the terminal of the glycolysis process, has recently been found to have multifaceted functional roles in metabolism and beyond.
Hongxia Tao, Xuansheng Zhong, Anqi Zeng, Linjiang Song   +3 more
doaj   +1 more source

Metabolic reprogramming in the tumor microenvironment: unleashing T cell stemness for enhanced cancer immunotherapy

Frontiers in Pharmacology, 2023
T cells play a pivotal role in the immune system by distinguishing between various harmful pathogens and cancerous cells within the human body and initiating an immune response.
Youhan Liu, Tao Wang, Wen Ma, Zixuan Jia, Qinglu Wang, Maoling Zhang, Ying Luo, Hongmei Sun   +7 more
doaj   +1 more source

Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?

Microorganisms, 2022
Background: The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis/septic shock have yet to be determined.
Bianca-Liana Grigorescu, Irina Săplăcan, Ioana Roxana Bordea, Marius Petrisor, Oana Coman, Claudiu Ion Puiac, Ariana Toncean, Raluca Stefania Fodor   +7 more
doaj   +1 more source

Layered Double Hydroxide-Modified Organic Electrochemical Transistor for Glucose and Lactate Biosensing

Sensors, 2020
Biosensors based on Organic Electrochemical Transistors (OECTs) are developed for the selective detection of glucose and lactate. The transistor architecture provides signal amplification (gain) with respect to the simple amperometric response.
Isacco Gualandi, Marta Tessarolo, Federica Mariani, Danilo Arcangeli, Luca Possanzini, Domenica Tonelli, Beatrice Fraboni, Erika Scavetta   +7 more
doaj   +1 more source

Immature platelet indices alongside procalcitonin for sensitive and specific identification of bacteremia in the intensive care unit

Platelets, 2021
Hematological markers that can be rapidly analyzed and regularly monitored during a patient’s stay on ICU, and that can identify bacterial causes of sepsis are being extensively sought.
Nathan Jones, Ascanio Tridente, Nina C. Dempsey-Hibbert   +2 more
doaj   +1 more source

Metabolic Assessment of Human Induced Pluripotent Stem Cells-Derived Astrocytes and Fetal Primary Astrocytes: Lactate and Glucose Turnover

Biosensors, 2022
Astrocytes represent one of the main cell types in the brain and play a crucial role in brain functions, including supplying the energy demand for neurons. Moreover, they are important regulators of metabolite levels.
Isabelle Matthiesen, Rohollah Nasiri, Alessandra Tamashiro Orrego, Thomas E. Winkler, Anna Herland   +4 more
doaj   +1 more source

Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation

Cells, 2020
Background: Renal cell carcinoma (RCC) displays a glycolytic phenotype (Warburg effect). Increased lactate production, impacting on tumor biology and microenvironment modulation, has been implicated in epigenetic mechanisms’ regulation, leading to ...
Vera Miranda-Gonçalves, Ana Lameirinhas, Catarina Macedo-Silva, João Lobo, Paula C. Dias, Verónica Ferreira, Rui Henrique, Carmen Jerónimo   +7 more
doaj   +1 more source

Identification of Lactate as a Cardiac Protectant by Inhibiting Inflammation and Cardiac Hypertrophy Using a Zebrafish Acute Heart Failure Model

Pharmaceuticals, 2021
Acute heart failure (AHF) commonly arises from decompensated chronic heart failure or sudden structural and functional breakdown causing a decrease in cardiac contractility and consequently fluid accumulation and systemic congestion.
Elijah R. Haege, Hui-Chi Huang, Cheng-chen Huang   +2 more
doaj   +1 more source