Results 51 to 60 of about 399,657 (248)

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning

İstanbul Medical Journal, 2019
Introduction:This study aimed to investigate lactate and lactate clearance and to determine the feasibility of the use of lactate clearance for assessing treatment efficacy in carbon monoxide (CO) poisoning.Methods:All patients aged 18 years and older ...
Seda Dağar, Emine Emektar, Hüseyin Uzunosmanoğlu, Şeref Kerem Çorbacıoğlu, Özge Öztekin, Yunsur Çevik   +5 more
doaj   +1 more source

Evaluation of microorganisms with sulfidogenic metabolic potential under anaerobic conditions

Brazilian Archives of Biology and Technology, 2012
The aim of this work was to identify groups of microorganisms that are capable of degrading organic matter utilizing sulfate as an electron acceptor.
Isabel Kimiko Sakamoto, Sandra Imaculada Maintinguer, Julia Sumiko Hirasawa, Maria Angela Tallarico Adorno, Maria Bernadete Amâncio Varesche   +4 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors

MedComm
Lactate, once dismissed as a mere by‐product of cancer metabolism, has emerged as a pivotal factor in tumor progression, exerting diverse effects on metabolic reprogramming and immune modulation. Lactate enhances tumor cell adaptability through sustained
Long Zhao, Haoyue Cui, Yutong Li, Yingjiang Ye, Zhanlong Shen   +4 more
doaj   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Relative Hyperlactatemia in the Emergency Department

Frontiers in Medicine, 2020
Objective: The clinical interpretation of lactate ≤ 2.00 mmol/L in emergency department (ED) patients is not well-characterized. This study aims to determine the optimal cutoff value for lactate within the reference range that predicts in-hospital ...
Ralphe Bou Chebl, Sarah Jamali, Nancy Mikati, Reem Al Assaad, Karim Abdel Daem, Nadim Kattouf, Rawan Safa, Maha Makki, Hani Tamim, Gilbert Abou Dagher   +9 more
doaj   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

QSOFA SCORE FOR DIAGNOSTICS OF SEPSIS. RESULTS OF THE RUSSIAN MULTI-CENTER TRIAL OF RISES

Вестник анестезиологии и реаниматологии, 2018
Subjects and methods. The multi-center, prospective, and observational trial was conducted. The following data were analyzed in the patients admitted to intensive care wards: number of qSOFAscores, the presence of SIRS criteria, levels of lactate ...
M. N. Astafieva, V. A. Rudnov, V. V. Kulаbukhov, V. A. Bаgin, N. A. Zubаrevа, M. A. Tribulev, S. Yu. Mukhаchevа   +6 more
doaj   +1 more source