Results 81 to 90 of about 980,886 (403)

Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF)

Journal of Neuroscience, 2019
Exercise promotes learning and memory formation. These effects depend on increases in hippocampal BDNF, a growth factor associated with cognitive improvement and the alleviation of depression symptoms.
Lauretta El Hayek, M. Khalifeh, V. Zibara, Rawad Abi Assaad, N. Emmanuel, Nabil Karnib, Rim El-Ghandour, Patrick Nasrallah, Maria Bilen, Pascal Ibrahim, J. Younes, Edwina Abou Haidar, Nour Barmo, Vanessa Jabre, Joseph S. Stephan, Sama F. Sleiman   +15 more
semanticscholar   +1 more source

Tetracycline and Lactation

The Journal of the American Dental Association, 1983
The Journal of the American Dental Association 107 (1983) 12,14-12,14.
UNIVERSITY OF FLORIDA, GAINESVILLE, FLAUNIVERSITY OF FLORIDAGAINESVILLEFLA ( host institution ), Hendeles, Leslie, Trask, Philip A.   +2 more
openaire   +4 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

Frontiers in Pharmacology, 2017
Slow and continuous release of H2S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells.
Zheng-Wei Lee, Xin-Yi Teo, Zhi J. Song, Dawn S. Nin, Dawn S. Nin, Wisna Novera, Bok A. Choo, Bok A. Choo, Brian W. Dymock, Brian W. Dymock, Philip K. Moore, Philip K. Moore, Ruby Y.-J. Huang, Ruby Y.-J. Huang, Ruby Y.-J. Huang, Lih-Wen Deng, Lih-Wen Deng, Lih-Wen Deng   +17 more
doaj   +1 more source

Dual‐Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic‐Chemodynamic Therapy

Advanced Science, 2021
Increasing evidence has demonstrated that lactate and adenosine triphosphate (ATP) both play important roles in regulating abnormal metabolism in the tumor microenvironment.
Feng Tian, Shiyao Wang, Keda Shi, Xingjian Zhong, Yutian Gu, Yadi Fan, Yu Zhang, Mo Yang   +7 more
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Serum lactate as a prognostic factor in coronary artery bypass graft operation by on pump method [PDF]

, 2013
Background: Lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. This investigation was designed to integrate basic concepts about lactate acidosis with a clinically ...
Alereza, H., Alijanpour, E., Banihashem, N., Jabbari, A., Rabiee, S.M., Vafaey, H.R.   +5 more
core   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Lactate Sensors on Flexible Substrates

Biosensors, 2016
Lactate detection by an in situ sensor is of great need in clinical medicine, food processing, and athletic performance monitoring. In this paper, a flexible, easy to fabricate, and low-cost biosensor base on lactate oxidase is presented. The fabrication
Xuesong Yang, Timothy Fu, Pavan Kumar Kota, Maggie Tjia, Cuong Manh Nguyen, Jung-Chih Chiao   +5 more
doaj   +1 more source