Results 11 to 20 of about 801,950 (399)
Evidences of basal lactate production in the main white adipose tissue sites of rats. Effects of sex and a cafeteria diet. [PDF]
PLoS ONE, 2015 Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the rats were killed and the white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric and subcutaneous (inguinal) were ...
Sofía Arriarán +5 more
doaj +11 more sources
Clinical observations of Leber hereditary optic neuropathy with and without neurological symptoms [PDF]
Анналы клинической и экспериментальной неврологии, 2022 Three case studies of adults with Leber hereditary optic neuropathy with and without neurological symptoms are presented. An elevated blood lactate level and changes in the activity of the mitochondrial enzymes in peripheral blood lymphocytes were noted.
Sergey V. Kotov +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Current approaches for producing T cells for adoptive immunotherapy for cancer rely on interleukin (IL)-2–based strategies that generate large numbers of tumor-reactive T cells but also drive the cells toward terminal differentiation and ...
D. Hermans +19 more
semanticscholar +1 more source
The usefulness of lactate dehydrogenase measurements in current oncological practice
Cellular & Molecular Biology Letters, 2020 One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and ...
Agata Forkasiewicz +5 more
semanticscholar +1 more source
Lactate dehydrogenase: a marker of diminished antitumor immunity
Oncoimmunology, 2020 Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor and tumor necrosis due to hypoxia, the latter being associated with high ...
Sandra van Wilpe +7 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 The oxidation of NADH with the concomitant reduction of a quinone is a crucial step in the metabolism of respiring cells. In this study, we analyzed the relevance of three different NADH oxidation systems in the actinobacterial model organism ...
Tomoya Maeda +2 more
doaj +1 more source
Clinical and Diagnostic Significance of Lactate Dehydrogenase and Its Isoenzymes in Animals
Veterinary Medicine International, 2020 Lactate dehydrogenase (LDH) is widely distributed enzyme in cells of various living systems where it is involved in carbohydrate metabolism catalyzing interconversion of lactate and pyruvate with NAD+/NADH coenzyme system.
R. Klein +3 more
semanticscholar +1 more source
Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma [PDF]
Archive of Oncology, 2008 Background: A rapid increase in the turnover of malignant cells modulates the enzymes level in circulation and may be a prognostic sign of disease progression.
Bogdanović Gordana +9 more
doaj +1 more source
Microbiome, 2022 Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the ...
Savannah J. Taylor +14 more
doaj +1 more source
High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii [PDF]
, 2016 Background: Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism.
Avcı, Fatma Gizem +5 more
core +3 more sources