Results 11 to 20 of about 231,763 (293)

Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma

Tumor Biology, 2017
Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua, Chao Liang, Jundong Zhu, Chenkui Miao, Yajie Yu, Aimin Xu, Jianzhong Zhang, Pu Li, Shuang Li, Meiling Bao, Jie Yang, Chao Qin, Zengjun Wang   +12 more
doaj   +1 more source

The utility of lactate dehydrogenase in the follow up of patients with diffuse large B-cell lymphoma

Revista Brasileira de Hematologia e Hemoterapia, 2013
Background: Serum lactate dehydrogenase is a non-specific marker for lymphoma whose prognostic significance is well established for both indolent and aggressive lymphomas at the time of diagnosis.
Basem Magdy William, Navneeth Rao Bongu, Martin Bast, Robert Gregory Bociek, Philip Jay Bierman, Julie Marie Vose, James Olen Armitage   +6 more
doaj   +1 more source

Real-world testing of serum lactate dehydrogenase among patients with metastatic colorectal cancer in the United States. [PDF]

Oncologist
Lenz HJ, Lunacsek O, Ostojic H, Pan X, Dochy E, Vassilev Z, Khan N.   +6 more
europepmc   +3 more sources

DIAGNOSTIC UTILITY OF SERUM LACTATE DEHYDROGENASE LEVELS (LDL) IN DIFFERENTIATING MEGALOBLASTIC ANEMIA FROM MYELODYSPLASTIC SYNDROMES IN PAKISTAN

Pakistan Armed Forces Medical Journal, 2021
Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan. Study Design: Comparative cross-sectional study.
Faraz Ali Rana, Helen Mary Robert, Madiha Ilyas, Asad Mahmood, Muhammad Amir, Nabeela Khan   +5 more
doaj  

Conformational features of lactate dehydrogenase: temperature effect in presence of small molecules, mathematical model

Бюллетень сибирской медицины, 2020
The aim of this work was to study the conformational changes of lactate dehydrogenase under the influence of different concentrations of intermediates (pyruvate, oxaloacetate) in the temperature gradient with the  subsequent building of a mathematical ...
F. N. Gilmiyarova, V. I. Kuzmicheva, N. A. Kolotyeva, M. V. Komarova, E. A. Ryskina, O. A. Gusyakova, D. S. Vinogradova, V. V. Salmin   +7 more
doaj   +1 more source

Evidences of basal lactate production in the main white adipose tissue sites of rats. Effects of sex and a cafeteria diet.

PLoS ONE, 2015
Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the rats were killed and the white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric and subcutaneous (inguinal) were ...
Sofía Arriarán, Silvia Agnelli, David Sabater, Xavier Remesar, José Antonio Fernández-López, Marià Alemany   +5 more
doaj   +1 more source

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Cell Reports, 2018
Summary: Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4).
Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall   +9 more
doaj   +1 more source

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

Cell Reports, 2020
Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier   +22 more
doaj   +1 more source

The D-Lactate Dehydrogenase from Sporolactobacillus inulinus Also Possessing Reversible Deamination Activity. [PDF]

PLoS ONE, 2015
Hydroxyacid dehydrogenases are responsible for the conversion of 2-keto acids to 2-hydroxyacids and have a wide range of biotechnological applications.
Lingfeng Zhu, Xiaoling Xu, Limin Wang, Hui Dong, Bo Yu   +4 more
doaj   +1 more source

A STUDY OF SERUM LACTATE AS A PREDICTOR OF SEVERITY IN DENGUE INFECTION

National Journal of Medical Research, 2023
Background: Dengue infections caused by the four antigenically distinct dengue virus serotypes (DENV1, DENV2, DENV3, DENV4) of the family Flaviviridae are the most major arboviral diseases in humans in terms of geographic spread, morbidity, and ...
Meet Ladani, Deepak Shukla, Rakesh Raval, Tejas Goyani, Srushti Vadodaria   +4 more
doaj   +1 more source