Results 121 to 130 of about 68,495 (247)

Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration

open access: yesAdvanced Therapeutics, EarlyView.
Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana   +5 more
wiley   +1 more source

Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery

open access: yesAdvanced Therapeutics, EarlyView.
Here, glycol chitosan (GC)‐coated PLGA NPs are developed to enhance oral drug delivery by enabling dual‐pathway endocytosis via clathrin‐ and caveolae‐mediated mechanisms. Alginate layering coating on GC‐PLGA further improves oral insulin delivery, achieving sustained glucose reduction in diabetic mice.
Huiwen Pang   +7 more
wiley   +1 more source

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

open access: yesAdvanced Science, EarlyView.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf   +7 more
wiley   +1 more source

Association between organic nitrogen substrates and the optical purity of d-lactic acid during the fermentation by Sporolactobacillus terrae SBT-1

open access: yesScientific Reports
The development of biotechnological lactic acid production has attracted attention to the potential production of an optically pure isomer of lactic acid, although the relationship between fermentation and the biosynthesis of highly optically pure d ...
Sitanan Thitiprasert   +7 more
doaj   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

open access: yesAdvanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen   +10 more
wiley   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun   +10 more
wiley   +1 more source

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