Results 71 to 80 of about 169,786 (297)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Lactobacillus terrae is a later heterotypic synonym of Lactobacillus metriopterae

International Journal of Systematic and Evolutionary Microbiology, 2019
Lactobacillus metriopterae and Lactobacillus terrae are closely related, and they share 99.5 % 16S rRNA gene sequence similarity, 98.4 % pheS gene sequence similarity, 99.6 % rpoA gene sequence similarity, 97.9 % average nucleotide identity value and 81.3 % in silico DNA-DNA hybridization value, showing that they have the same taxonomic position.
Wei Zhao, Chun Tao Gu
openaire   +3 more sources

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

β-Galactosidase from strains isolated from breast milk and infant saliva: characterization and participation in absorption of different oligosaccharides

Journal of BioScience and Biotechnology, 2019
Lactobacillus are Gram-positive anaerobic bacteria that naturally occur in the human intestinal tract. They are considered to be beneficial commensals for human health because they prevent the growth of pathogenic bacteria by lowering the intestinal pH ...
Daniela Mollova, Tonka Vasileva, Iliya Iliev   +2 more
doaj  

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

eLife, 2018
Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota.
Sara C Di Rienzi, Juliet Jacobson, Elizabeth A Kennedy, Mary E Bell, Qiaojuan Shi, Jillian L Waters, Peter Lawrence, J Thomas Brenna, Robert A Britton, Jens Walter, Ruth E Ley   +10 more
doaj   +1 more source

Gut Parabacteroides distasonis‐derived Indole‐3‐Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR‐FASN Axis in Bladder Cancer

Advanced Science, EarlyView.
Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li, Wentai Shangguan, Wenxue Huang, Jie Zhao, Yuexuan Zhu, Ming Xie, Yao Yu, Qishen Yang, Jun Zheng, Lin Yang, Qi Sun, Leqian Li, Xinhang Shi, Yongyuan Xiao, Hai Huang, Bisheng Cheng, Peng Wu   +16 more
wiley   +1 more source

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

Probiotic‐Enhanced Porous Bio‐Hybrids with Inflammatory Targeting, ROS Scavenging, and Long‐Term Drug Release for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
Probiotic‐enhanced porous bio‐hybrids (E‐xPAM@ASA), developed by coupling the drug‐loaded hairy microporous nanospheres xPAM@ASA with probiotic EcN, integrate inflammatory‐targeting, ROS scavenging, and long‐term release of 5‐ASA to improve inflammation and regulate microbiota structure in the DSS‐induced colitis model, providing an advanced strategy ...
Luna Quan, Yang Ouyang, Weiwen Liang, Zixin Chen, Dongtian Miao, Bingna Zheng, Dingcai Wu, Rongkang Huang   +7 more
wiley   +1 more source

Lactobacillus homohiochii is a later heterotypic synonym of Lactobacillus fructivorans

International Journal of Systematic and Evolutionary Microbiology, 2019
The taxonomic relationship of Lactobacillus fructivorans and Lactobacillus homohiochii was re-evaluated. The type strains of these two species shared 100 % 16S rRNA gene sequence similarity, 100 % pheS gene sequence similarity, 100 % rpoA gene sequence similarity, a 99.8 % ANI (average nucleotide identity) value and a 99.1 % in silico DNA-DNA ...
Chun Tao Gu, Wei Zhao
openaire   +3 more sources