Results 121 to 130 of about 25,988 (242)

Hyptolactones and Their Biological Potential: A Systematic Review. [PDF]

J Nat Prod
Julião FGH, da Silva JA.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Antifungal Activity of Four Medium-Chain Fatty Acids and γ-Undecalactone Against <i>Candida albicans</i>. [PDF]

Curr Issues Mol Biol
Yoshida M, Terada H, Hayashi S, Haraguchi T, Watanabe M, Yamashita M, Yoshii M, Hatanaka Y, Nagao T.   +8 more
europepmc   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

The Approximate Subcutaneous LD₅₀ and Associated Lesions Induced by Ivalin, Extracted and Purified from <i>Geigeria aspera</i> Harv., in Sprague-Dawley Rats. [PDF]

Molecules
Locke S, Botha C, Clift S, Lensink A.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Diurnal and Daily Changes in the Levels of Sesquiterpene Lactone and Other Components in Lettuce Post-Harvest. [PDF]

Molecules
Kamata K, Okada H, Ohta Y.
europepmc   +1 more source

Contact Sensitization in Adults With Atopic Dermatitis: A 21‐Year Single‐Center Tertiary Experience

Contact Dermatitis, EarlyView.
A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Francesca Caroppo, Anna Zambello, Giulia Biolo, Fortunato Cassalia, Laura Ventura, Anna Belloni Fortina   +5 more
wiley   +1 more source

Novel DAG-Lactone-Based Vav1 Inhibitors Show Anti-proliferative Activity in Pancreatic Cancer Models. [PDF]

ChemMedChem
Bellomo A, Toruner M, Elhalem E, Peach ML, Gandolfi Donadío L, Giordano L, Hogenson TL, Fernandez-Zapico ME, Comin MJ.   +8 more
europepmc   +1 more source

Patch Testing in Individuals With Diabetes Using Medical Devices. Part 1—Contact Allergy to Baseline Series Allergens

Contact Dermatitis, EarlyView.
The contact allergy prevalence in individuals with diabetes and in diabetes medical device (MD) users is unknown. This study in 204 diabetes MD users (114 with rash to diabetes MDs, 90 without) aimed at investigating the contact allergy prevalence to baseline series allergens. Contact allergies to sesquiterpene lactone mix and myroxylon pereirae resin (
Thanisorn Sukakul, Josefin Ulriksdotter, Martin Mowitz, Magnus Bruze, Nils Hamnerius, Cecilia Svedman   +5 more
wiley   +1 more source