Results 141 to 150 of about 103,978 (290)

Dopamine D3 receptor blockade accelerates the extinction of opioid withdrawal‐induced drug‐seeking behaviours and alters microglia in dopaminoceptive nuclei

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Among all drugs of abuse, opioids cause most of the deaths and treatment seeking. Despite abundant research in multifaceted therapeutic strategies, a high rate of relapse still characterises this condition. Dopamine D3 receptor antagonists combined with cue‐exposure therapies have been proposed to ameliorate the abused drugs ...
Aurelio Franco‐García   +3 more
wiley   +1 more source

Immobilization of enzymes for synergy in polymers to produce lactose free milk. [PDF]

open access: yesSci Rep
Peta G   +4 more
europepmc   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin   +13 more
wiley   +1 more source

Real‐world insights into incretin‐based therapy: Associations between changes in taste perception and appetite regulation in individuals with obesity and overweight: A cross‐sectional study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This cross‐sectional study examined associations between self‐reported taste perception changes and appetite‐related outcomes in individuals with obesity treated with glucagon‐like peptide‐1 receptor agonist (GLP‐1 RAS) or dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 RAS in real‐world conditions.
Ali Kapan   +4 more
wiley   +1 more source

Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering

open access: yesThe FEBS Journal, EarlyView.
We present a computational metric that quantifies the electrostatic complementarity of enzymes to the charge distribution of substrates at the transition state. Implemented in BindScan, this metric accurately predicts functionally relevant mutations in glycoside hydrolases.
Aitor Vega, Antoni Planas, Xevi Biarnés
wiley   +1 more source

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