Results 41 to 50 of about 102,744 (263)
Pharmaceutics, 2021 Lactose is a commonly used component of pharmaceutical medications in tablet form. It was previously shown that lactose changes conformationally after saturation in fluidized beds with active pharmaceutical ingredients obtained by repeated dilution of ...
Anna Baranova +3 more
doaj +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro +25 more
wiley +1 more source
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
Diagnostics, 2022 Tuberculosis is one of the most frequent causes of death in humans worldwide. One of the primary reasons tuberculosis remains a public health threat is that diagnosis can take weeks to months, is often not very sensitive and cannot be accomplished in ...
Maxim Lebedev +6 more
doaj +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 2017 Bu araştırma, Jersey ırkı ineklerde, California Mastitis Test (CMT) skorlarının süt verimi, süt bileşimi ve subklinik mastitis tanısı ile ilişkisini ve test skorlarının değerlendirilmesindeki farklılığın süt verimi, süt bileşimi ve subklinik mastitis ...
Filiz AKDAĞ +4 more
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What we should know about the carbohydrate component of infant formula
Медицинский совет, 2021 The article is devoted to the discussion of the carbohydrate component of infant formula for feeding healthy and sick children. The role of glycemic and non-glycemic carbohydrates is shown. In addition to lactose, the following glycemic carbohydrates can
I. N. Zakharova, A. A. Davydovskaya
doaj +1 more source
Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery
Advanced Science, EarlyView.Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie +11 more
wiley +1 more source
Powder Technology and Pharmaceutical Development: Particle Size and Particle Adhesion
KONA Powder and Particle Journal, 2013 Both the FDA (U.S. Food and Drug Administration) and ICH (International Conference on Harmonisation) have urged the incorporation of Quality by Design (QbD)1) into the manufacture of pharmaceutical products2).The performance of many pharmaceutical ...
Frank M. Etzler, Mohammad Nasir Uddin
doaj +1 more source