Results 41 to 50 of about 7,301 (235)

Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride

Journal of Lipid Research, 2003
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral ...
Jacques Bodennec, Selena Trajkovic-Bodennec, Anthony H. Futerman   +2 more
doaj   +1 more source

Synthesis and biological evaluation of novel PDMP analogues [PDF]

, 2006
A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana, Busson, Roger, Futerman, Anthony H, Hillaert, Ulrik, Rozenski, Jef, Van Calenbergh, Serge   +5 more
core   +1 more source

No evidence for substrate accumulation in Parkinson brains with GBA mutations [PDF]

, 2015
To establish whether Parkinson's disease (PD) brains previously described to have decreased glucocerebrosidase activity exhibit accumulation of the lysosomal enzyme's substrate, glucosylceramide, or other changes in lipid ...
Gegg, ME, Sardi, SP, Schapira, AH, Shihabuddin, LS, Sweet, L, Wang, BH   +5 more
core   +1 more source

Sphingolipids in human synovial fluid : a lipidomic study [PDF]

, 2014
Articular synovial fluid (SF) is a complex mixture of components that regulate nutrition, communication, shock absorption, and lubrication. Alterations in its composition can be pathogenic. This lipidomic investigation aims to quantify the composition of
Kaesser, Ulrich, Klein, Heiko, Kosinska, Marta Krystyna, Lasczkowski, Gabriele, Liebisch, Gerhard, Lochnit, Guenter, Proost, Paul, Rickert, Markus, Schmitz, Gerd, Steinmeyer, Juergen, Wilhelm, Jochen   +10 more
core   +6 more sources

Glycosphingolipid levels in an unusual neurovisceral storage disease characterized by lactosylceramide galactosyl hydrolase deficiency: lactosylceramidosis

Journal of Lipid Research, 1972
The glycosphingolipid composition of brain and visceral tissue from a patient with an unusual neurovisceral lipid storage disease, characterized by a lactosylceramide galactosyl hydrolase deficiency, was determined. Analyses of erythrocytes, plasma, bone
Glyn Dawson
doaj   +1 more source

A Patient With Encephalomyeloradiculoneuropathy Exhibiting a Relapsing–Remitting Clinical Course: Correlation of Serum and Cerebrospinal Fluid Anti-Neutral Glycosphingolipids Antibodies With Clinical Relapse

Frontiers in Neurology, 2018
Several patients who had a progressive clinical course involving both the central and peripheral nervous systems have been reported, but the diagnostic marker has been remained uncertain.
Hitoki Nanaura, Hiroshi Kataoka, Sayuri Shima, Naoki Iwasa, Nobuyuki Eura, Kazuma Sugie, Tatsuro Mutoh, Satoshi Ueno   +7 more
doaj   +1 more source

Induced Pluripotent Stem Cells Derived from a CLN5 Patient Manifest Phenotypic Characteristics of Neuronal Ceroid Lipofuscinoses [PDF]

, 2017
Neuronal ceroid lipofuscinoses (NCLs) are autosomal recessive progressive encephalopathies caused by mutations in at least 14 different genes. Despite extensive studies performed in different NCL animal models, the molecular mechanisms underlying ...
Blom, Tea, Blom, Tomas, Jalanko, Anu, Kyttala, Aija, Uusi-Rauva, Kristiina, von Schantz-Fant, Carina   +5 more
core   +2 more sources

Glycosphingolipids from cultured astroblasts

Journal of Lipid Research, 1977
The glycolipids of two clonal lines astroblasts, NN clone and C6 clone, were studied. Glucosylceramide and lactosylceramide were present at very low levels in both clones, but the most common myelin glycolipids galactosylceramide and sulfatide, were not ...
J Robert, G Rebel, P Mandel
doaj   +1 more source

Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice

PLoS Genetics, 2018
It is uncertain which β4-galactosyltransferase (β4GalT; gene name, B4galt), β4GalT-5 and/or β4GalT-6, is responsible for the production of lactosylceramide (LacCer) synthase, which functions in the initial step of ganglioside biosynthesis.
T. Yoshihara, H. Satake, Toshikazu Nishie, N. Okino, T. Hatta, H. Otani, Chie Naruse, Hiroshi Suzuki, Kazushi Sugihara, E. Kamimura, N. Tokuda, K. Furukawa, Koichi Fururkawa, Makoto Ito, M. Asano   +14 more
semanticscholar   +1 more source

Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.

PLoS ONE, 2013
In a xenograft model wherein, live renal cancer cells were implanted under the kidney capsule in mice, revealed a 30-fold increase in tumor volume over a period of 26 days and this was accompanied with a 32-fold increase in the level of lactosylceramide (
Subroto Chatterjee, Nezar Alsaeedi, Jennifer Hou, Veera Venkata Ratnam Bandaru, Lan Wu, Marc K Halushka, Roberto Pili, Georges Ndikuyeze, Norman J Haughey   +8 more
doaj   +1 more source