Results 21 to 30 of about 4,156 (155)

Plasma Sphingolipid Profile Associated With Subclinical Atherosclerosis and Clinical Disease Markers of Systemic Lupus Erythematosus: Potential Predictive Value

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects females more than males, with African Americans developing more severe manifestation of the disease.
Samar M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates, Jim C. Oates   +6 more
doaj   +1 more source

Sphingolipid Analysis Indicate Lactosylceramide as a Potential Biomarker of Inflammatory Bowel Disease in Children

Biomolecules, 2020
An altered ceramide composition in patients with inflammatory bowel disease (IBD) has been reported recently. The aim of this study was to evaluate the concentrations of sphingolipids in the serum of treatment-naive children with newly diagnosed IBD and ...
Aleksandra Filimoniuk, Agnieszka Blachnio-Zabielska, Monika Imierska, Dariusz Marek Lebensztejn, Urszula Daniluk   +4 more
doaj   +1 more source

Serum sphingolipid profiling as a novel biomarker for metabolic syndrome characterization

Frontiers in Cardiovascular Medicine, 2022
BackgroundSphingolipids are components of cell membrane structure, but also circulate in serum and are essential mediators of many cellular functions. While ceramides have been proposed previously as a useful biomarker for cardiometabolic disease, the ...
Loni Berkowitz, Cristian Salazar, Carol D. Ryff, Christopher L. Coe, Attilio Rigotti   +4 more
doaj   +1 more source

Lipidomics analysis of monocytes from patients with acute myocardial infarction reveals lactosylceramide as a new player in monocyte migration

, 2021
Monocyte recruitment after vascular injury and their migration through the vessel wall represent crucial events in the initiation, progression, and destabilization of atherosclerotic plaque.
Colombo, Gualtiero I, Tremoli, Elena, Barbieri, Simone, Porro, Benedetta, Fiorelli, Susanna, Cosentino, Nicola, Eligini, Sonia, Werba, José P, Manega, Chiara Maria, Marenzi, Giancarlo, Cavalca, Viviana, Anesi, Andrea, Di Minno, Alessandro   +12 more
core   +1 more source

Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease.

Journal of Lipid Research, 1996
Polycystic kidney disease (PKD) is a common genetic disease characterized by the proliferation of epithelial cells, formation of cysts, and the progression of renal deficiency.
S Chatterjee, W Y Shi, P Wilson, A Mazumdar   +3 more
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease. [PDF]

Adv Sci (Weinh)
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Huang Z, Liu YY, Sun H, Liu P.
europepmc   +2 more sources

Relationship of membrane phospholipid composition, lactosylceramide molecular species, and the specificity of CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase to the molecular species composition of GM3 ganglioside.

Journal of Lipid Research, 1995
The ceramide molecular species specificity of rat brain neuron CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase (LacCer alpha 2,3-ST) was determined using 19 molecular species of lactosylceramide incorporated into liposomes prepared ...
H. Kadowaki, M.A. Grant
doaj   +1 more source

Lactosylceramide contributes to mitochondrial dysfunction in diabetes

Journal of Lipid Research, 2016
Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we ...
Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz   +8 more
doaj   +1 more source

Lactosylceramide galactosidase: Comparison with other sphingolipid hydrolases in developing rat brain [PDF]

, 1969
Four enzyme assays were carried out with brains from rats of age 4 days to about 320 days. The enzymes were acid hydrolases: lactosylceramide galactosidases, galactosylphenol galactosidase, glucosylceramide glucosidase,a nd sphingomyelin phosphocholine ...
Brady, Roscoe O., Hof, Liselotte, Radin, Norman S., Bradley, Roy M.   +3 more
core   +1 more source

Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride

Journal of Lipid Research, 2003
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral ...
Jacques Bodennec, Selena Trajkovic-Bodennec, Anthony H. Futerman   +2 more
doaj   +1 more source