Results 11 to 20 of about 4,156 (155)

Glucosylceramide modulates membrane traffic along the endocytic pathway [PDF]

Journal of Lipid Research, 2002
Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the ...
Dan J. Sillence, Vishwajeet Puri, David L. Marks, Terry D. Butters, Raymond A. Dwek, Richard E. Pagano, Frances M. Platt   +6 more
doaj   +2 more sources

A new assay for determining ganglioside sialyltransferase activities lactosylceramide-2,3-sialyltransferase (SAT I) and monosialylganglioside-2,3-sialyltransferase (SAT IV). [PDF]

PLoS ONE, 2014
A new assay for the determination of lactosylceramide-2,3-sialyltransferase (SAT I, EC 2.4.99.9) and monosialoganglioside sialyltransferase (SAT IV, EC 2.4.99.2) is described.
Cynthia Q Sun, Ulrike Hubl, Petra Hoefakker, Madhusudan K Vasudevamurthy, Keryn D Johnson   +4 more
doaj   +2 more sources

Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation. [PDF]

PLoS ONE, 2010
The sialidase activity of neuraminidase-1 (Neu-1) is responsible for ERK 1/2 pathway activation following binding of elastin peptide on the elastin receptor complex.
Anthony Rusciani, Laurent Duca, Hervé Sartelet, Aurore Chatron-Colliet, Hélène Bobichon, Dominique Ploton, Richard Le Naour, Sébastien Blaise, Laurent Martiny, Laurent Debelle   +9 more
doaj   +2 more sources

Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study. [PDF]

PLoS ONE, 2015
Existing data on the association between being overweight and cardiovascular morbidity and mortality risk in adults are inconsistent. We prospectively and longitudinally investigated the effects of weight on arterial stiffness and plasma metabolites in ...
Minjoo Kim, Saem Jung, Sang-Hyun Lee, Jong Ho Lee   +3 more
doaj   +2 more sources

Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.

PLoS ONE, 2013
In a xenograft model wherein, live renal cancer cells were implanted under the kidney capsule in mice, revealed a 30-fold increase in tumor volume over a period of 26 days and this was accompanied with a 32-fold increase in the level of lactosylceramide (
Subroto Chatterjee, Nezar Alsaeedi, Jennifer Hou, Veera Venkata Ratnam Bandaru, Lan Wu, Marc K Halushka, Roberto Pili, Georges Ndikuyeze, Norman J Haughey   +8 more
doaj   +2 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl-Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies. [PDF]

Angew Chem Int Ed Engl
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
de Koster N, Vidal-Gironès Ò, de Graaf R, Kok K, Lelieveld LT, Hoogervorst J, Ferraz MJ, Rivas-Fernández JP, Lammers RF, Overkleeft HS, Aerts JMFG, Boot RG, Rovira C, Artola M.   +13 more
europepmc   +3 more sources

Bi-allelic inactivating variants of lactosylceramide synthase B4GALT5 responsible for a novel congenital disorder of glycosylation involving glycosphingolipids

, 2023
A 10-year-old girl of Italian ancestry presenting with developmental delay, intellectual disability, microcephalia, and bilateral cataract was found to carry compound heterozygous variants in the B4GALT5 gene encoding a galactosyltransferase producing ...
Brunetti­Pierri N., Dei Cas M., Caretti A., de Matteis M. A., Montavoci L., Cappuccio G., Trinchera M   +6 more
core   +7 more sources

Convenient and Sensitive Measurement of Lactosylceramide Synthase Activity Using Deuterated Glucosylceramide and Mass Spectrometry [PDF]

, 2023
Lactosylceramide is necessary for the biosynthesis of almost all classes of glycosphingolipids and plays a relevant role in pathways involved in neuroinflammation.
Montavoci, Linda, Casati, Sara, Malagolini, Nadia, Trinchera, Marco, Dei Cas, Michele, Sara Casati, Michele Dei Cas, Fabio Dall’Olio, Marco Trinchera, Nadia Malagolini, Linda Montavoci, Dall'Olio, Fabio   +11 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma. [PDF]

Mol Oncol
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Kerkhoff L, Moritz M, Eggert D, Worthmann A, Heeren J, Zech H, Clauditz TS, Wilczak W, Schlüter H, Betz CS, Böttcher A, Hahn J.   +11 more
europepmc   +2 more sources

Comparison of Nasal Mucus Metabolites in Chronic Rhinosinusitis With and Without Polyps and Healthy Controls. [PDF]

OTO Open
Abstract Objective To identify differences in nasal mucus metabolites from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) and healthy controls. Study Design Cross‐sectional. Setting Single institution tertiary care facility.
Armstrong MF, Bartemes KR, Hunter DE, Griesel MD, Voss SG, Choby GW, Pinheiro Neto CD, Hagan JB, Divekar RD, O'Brien EK.   +9 more
europepmc   +2 more sources