Results 41 to 50 of about 4,156 (155)

Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination

Frontiers in Neurology, 2019
We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right ...
Masaya Harada, Shiroh Miura, Hiroshi Kida, Taiga Moritaka, Ken-ichi Irie, Takashi Kamada, Yusuke Uchiyama, Sayuri Shima, Tatsuro Mutoh, Tomoaki Hoshino, Takayuki Taniwaki   +10 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Sphingolipid composition of human platelets

Journal of Lipid Research, 1973
Total lipid extracts from washed trypsinized human platelets were fractionated into neutral lipids, glycosphingolipids, and phosphclipids by silicic acid chromatography.
Robert V.P. Tao, Charles C. Sweeley, Graham A. Jamieson   +2 more
doaj   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Streptococcus suis Capsular Polysaccharide Inhibits Phagocytosis through Destabilization of Lipid Microdomains and Prevents Lactosylceramide-Dependent Recognition

, 2012
Streptococcus suis type 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans. S. suis infects the host through the respiratory route, reaches the bloodstream, and persists until
Marie-Rose Van Calsteren, Marcelo Gottschalk, Mathieu Houde, Mariela Segura, Fleur Gagnon   +4 more
core   +1 more source

Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis

Frontiers in Pharmacology
IntroductionCardiac hypertrophy is a compensatory stress response produced by a variety of factors, and pathologic hypertrophy can lead to irreversible, severe cardiac disease.
Chunxin Jiang, Menglei Tan, Lunmeng Lai, Yanping Wang, Zijun Chen, Qing Xie, Yunsen Li   +6 more
doaj   +1 more source

Lactosylceramide molecular species specificity of rat liver CMP-N-acetylneuraminate:lactosylceramide sialyltransferase.

Journal of Lipid Research, 1989
Six naturally occurring and three synthetic molecular species of lactosylceramide (LacCer) were used to examine the molecular species specificity of CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase in a Golgi-rich fraction of rat ...
H Kadowaki, L A Symanski, K E Rys-Sikora, R S Koff   +3 more
doaj   +1 more source

Analyses of lactosylceramide and lactosylsphingosine levels by LC/MS.

, 2013
Lactosylceramide (LacCer) level was not decreased in IFG treated 4L;C* cortex relative to the untreated mice. Increased lactosylsphingosine (LacSph) was detected in 600 mg/kg/d IFG treated cortex at 44 days.
Gregory A. Grabowski (353044), Ying Sun (23237), Jacek Bielawski (251333), Huimin Ran (353034), Brian Quinn (353037), Benjamin Liou (353035), Wujuan Zhang (353041), Matt Zamzow (353039), Kenneth D. R. Setchell (275564), Kazuyuki Kitatani (353042), Yusuf A. Hannun (116276)   +10 more
core   +1 more source

Simultaneous fractionation of four placental neutral glycosphingolipids with a continuous gradient.

Journal of Lipid Research, 1989
We describe a method for isolating milligram quantities of the four neutral glycosphingolipids, glucocerebroside, lactosylceramide, traiosylceramide, and globoside, from human placental tissue.
P Strasberg, A Grey, I Warren, M A Skomorowski   +3 more
doaj   +1 more source

Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils

, 2008
The neutral glycosphingolipid lactosylceramide (LacCer) forms lipid rafts (membrane microdomains) coupled with the Src family kinase Lyn on the plasma membranes of human neutrophils; ligand binding to LacCer activates Lyn, resulting in neutrophil ...
Kumiko Ishii, A.E.G. Prinetti, L. Mauri, Laura Mauri, Hidetake Kurihara, Fumiko Yoshizaki, Kenji Takamori, Kazuhisa Iwabuchi, N. Kaga, K. Murayama, S. Sonnino, Hideoki Ogawa, Isao Nagaoka, F. Yoshizaki, Alessandro Prinetti, Sandro Sonnino, K. Iwabuchi, H. Kurihara, Toshihide Kobayashi, Naoko Kaga, H. Ogawa, H. Nakayama, K. K. Ishii, Kimie Murayama, I. Nagaoka, Hitoshi Nakayama, K. Takamori, T. Kobayashi   +27 more
core   +1 more source