The potential role of lactulose pharmacotherapy in the treatment and prevention of diabetes
Frontiers in Endocrinology, 2022 The non-absorbable disaccharide lactulose is mostly used in the treatment of various gastrointestinal disorders such as chronic constipation and hepatic encephalopathy.
Natural Chu +4 more
doaj +2 more sources
Low-Dose Lactulose as a Prebiotic for Improved Gut Health and Enhanced Mineral Absorption
Frontiers in Nutrition, 2021 Although medium and high doses of lactulose are used routinely for the treatment of constipation and hepatic encephalopathy, respectively, a wealth of evidence demonstrates that, at low doses, lactulose can also be used as a prebiotic to stimulate the ...
Tarkan Karakan +2 more
doaj +2 more sources
Hospitalizations and healthcare costs associated with rifaximin versus lactulose treatment among commercially insured patients with hepatic encephalopathy in the United States [PDF]
Journal of Medical Economics, 2021 Aims To assess healthcare costs and hospitalization rates associated with rifaximin therapy versus lactulose alone among patients at risk for hepatic encephalopathy (HE).
Michael L. Volk +6 more
openalex +2 more sources
Lactulose therapy for patients with cirrhosis, portal hypertension, and poor patient-reported outcomes: The Mi-Kristal trial [PDF]
Hepatology, 2023 Background and Aims: Poor patient-reported outcomes (PROs) are common in cirrhosis, including poor sleep and health-related quality of life (HRQOL). HE is a major driver of poor PROs. Many clinicians initiate lactulose therapy to address poor PROs.
Elliot B. Tapper +4 more
openalex +2 more sources
Microbiota stability in healthy individuals after single-dose lactulose challenge-A randomized controlled study. [PDF]
PLoS ONE, 2018 BACKGROUND AND AIMS:Lactulose is a common food ingredient and widely used as a treatment for constipation or hepatic encephalopathy and a substrate for hydrogen breath tests.
Sandra Y Wotzka +14 more
doaj +2 more sources
Frontiers in Microbiology, 2023 Background Minimal hepatic encephalopathy (MHE) is an early stage in the pathogenesis of hepatic encephalopathy. Intestinal microbiota is involved in the pathogenesis of hepatic encephalopathy and has become an important therapeutic target.
Ming-Wei Wang +6 more
semanticscholar +1 more source
Lactulose in cirrhosis: Current understanding of efficacy, mechanism, and practical considerations
Hepatology Communications, 2023 HE is a complication of cirrhosis characterized by neuropsychiatric and motor dysfunction, and results in decreased quality of life and increased mortality.
P. Bloom, Elliot B. Tapper
semanticscholar +1 more source
Journal of Animal Science and Biotechnology, 2023 Lactulose as an effective prebiotic protects intestinal mucosal injury. Bacillus coagulans is widely used in feed additives because of its ability to promote intestinal health.
Weijiang Zheng +4 more
semanticscholar +1 more source
Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS
Hepatology, EarlyView., 2022 The river diagram demonstrates that after transjugular intrahepatic portosystemic shunt insertion (TIPS) the majority of patients without ascites and 50% of the patients with ascites detectable at ultrasound, show the best response in the long term follow‐up.
Alexander Queck +14 more
wiley +1 more source
Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis
Nutrients, 2022 Lactulose, a galactose-fructose disaccharide, is made from the milk sugar lactose by heating or isomerization processes. Lactulose is proposed to modulate gut microbiota and thus expected to be beneficial in treating inflammatory bowel disease.
Keizo Hiraishi +9 more
semanticscholar +1 more source