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Lambert-Eaton Myasthenic Syndrome

BMJ Case Reports
Lambert-Eaton myasthenic syndrome is a disorder of neuromuscular transmission in which an autoantibody is directed against the pre-synaptic calcium channel. It presents with proximal limb weakness, greater in the legs, with or without peripheral and autonomic neuropathy. Bulbar involvement is rare and fatigueability is not a feature.
Jayarangaiah A, Lui F, Theetha Kariyanna P.   +2 more
europepmc   +12 more sources

Lambert‐Eaton myasthenic syndrome with primary thymic marginal zone B‐cell lymphoma: A case report [PDF]

Respirology Case Reports, 2023
Lambert‐Eaton myasthenic syndrome (LEMS) is an autoimmune paraneoplastic syndrome with proximal muscle weakness, that often complicates small cell lung cancer.
Toshihiko Soma, Akira Matsumoto, Tsuyoshi Shoji, Hiromichi Katakura   +3 more
doaj   +2 more sources

Nationwide survey of Lambert-Eaton myasthenic syndrome in Japan [PDF]

BMJ Neurology Open, 2022
Background There was no nationwide epidemiological study of Lambert-Eaton myasthenic syndrome (LEMS) in Japan; therefore, we conducted a nationwide survey.Methods For the first survey, we sent survey sheets to randomly selected medical departments (n ...
Yutaka Furukawa, Satoshi Kuwabara, Nagato Kuriyama, Yoshiko Nomura, Yasunari Sakai, Makoto Matsui, Yosikazu Nakamura, Hiroyuki Murai, Yumi Adachi, Hiroaki Yoshikawa, Kazuo Iwasa   +10 more
doaj   +2 more sources

Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome: New Developments in Diagnosis and Treatment [PDF]

Neuropsychiatric Disease and Treatment, 2022
Robert M Pascuzzi, Cynthia L Bodkin Indiana University School of Medicine, Indiana University Health, Indianapolis, IN, USACorrespondence: Robert M Pascuzzi, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN, 46202, USA ...
Pascuzzi RM, Bodkin CL
doaj   +2 more sources

Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report [PDF]

Radiology Case Reports, 2023
Spontaneous regression (SR) of cancer is very rare, especially of small cell lung cancer (SCLC). Recently, an association of paraneoplastic neurological syndrome (PNS) has been reported as a cause of SR of cancer, and onconeural antibodies are a possible
Michimi Otani, MD, Miki Nishimori, MD, PhD, Hitomi Iwasa, MD, PhD, Mamiko Iwamura, MD, Takayasu Izumi, MD, Kosuke Nakaji, MD, Noriko Nitta, MD, Kana Miyatake, MD, Rika Yoshimatsu, MD, PhD, Tomoaki Yamanishi, MD, Tomohiro Matsumoto, MD, PhD, Yasushi Osaki, MD, PhD, Noriko Wada, MD, Makoto Toi, MD, PhD, Marino Yamamoto, MD, PhD, Yu Nakatani, MD, Tetsuya Kubota, MD, PhD, Takuji Yamagami, MD, PhD   +17 more
doaj   +2 more sources

Lambert–Eaton myasthenic syndrome presenting with occult mediastinal small cell carcinoma and positivity for anti-CV2/CRMP5 and anti-SOX1 antibodies: a case report [PDF]

BMC Neurology
Background Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular disorder characterized by proximal muscle weakness, autonomic dysfunction and hyporeflexia.
Anna Wang, He Li, Dewen Li, Kangfeng Wang, Lijuan Zhang   +4 more
doaj   +2 more sources

Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study [PDF]

BMC Neurology
This is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm.
David P. Randall, Matthew C. Randall
doaj   +2 more sources

Efficacy of durvalumab plus chemotherapy in small-cell lung cancer with Lambert-Eaton myasthenic syndrome [PDF]

Respiratory Medicine Case Reports
Lambert-Eaton myasthenic syndrome (LEMS) is a rare disease but is often associated with small-cell lung cancer (SCLC). We discuss the case of a 65-year-old man diagnosed with SCLC-LEMS and treated with carboplatin, etoposide, and durvalumab.
Naoya Ishibashi, Toshiharu Tabata, Ryo Nonomura, Yutaka Oshima, Takanobu Sasaki, Hideki Mitomo, Takafumi Sugawara, Motoyasu Sagawa   +7 more
doaj   +2 more sources

SOX‐1 antibodies positive Lambert–Eaton myasthenic syndrome with occult small cell lung cancer: A case report [PDF]

The Clinical Respiratory Journal
Lambert–Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage.
Liming Zhao, Hongyan He, Weixin Han, Yizhe Meng, Lifei Kang, Yanqiang Chen   +5 more
doaj   +2 more sources

Lambert-Eaton myasthenic syndrome [PDF]

Postgraduate Medical Journal, 1999
SummaryThe Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltage-gated calcium channels (VGCC) which is an essential component of
U, Seneviratne, R, de Silva
openaire   +3 more sources