Results 111 to 120 of about 52,713 (325)

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

bioRxiv, 2021
Emily Bell, Pragya Shah, Noam Zuela-Sopilniak, Dongsung Kim, A. Varlet, Julien L. P. Morival, A. McGregor, Philipp Isermann, P. Davidson, Joshua J. Elacqua, Jon N. Lakins, L. Vahdat, V. Weaver, M. Smolka, P. Span, J. Lammerding   +15 more
semanticscholar   +1 more source

Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation

bioRxiv, 2019
The nucleus is the largest organelle and information center of the cell; while we identify the diverse components of the cells as mechanotransduction elements, the deformation of the nucleus itself is emerging as a critical mechanosensory structure ...
Luv Kishore Srivastava, Zhaoping Ju, Ajinkya Ghagre, A. Ehrlicher   +3 more
semanticscholar   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

Cell Death and Disease, 2019
p53-mediated cellular senescence has been intensively investigated, because it is important for tumor suppressive function. In addition, p16/INK4A is well known to be critical for cellular senescence.
Min-Ho Yoon, So-mi Kang, Su-Jin Lee, Tae-Gyun Woo, A. Oh, Soyoung Park, N. Ha, Bum-Joon Park   +7 more
semanticscholar   +1 more source

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

Cancer Communications, EarlyView.
Abstract Background Phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three‐dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored.
Sunyoung Jang, Sumin Yoon, Hyeokjun Yang, Nayun Choi, Su‐Hyang Han, Lark Kyun Kim, Hyoung‐Pyo Kim, Jong Hoon Park, Daeyoup Lee, Kyung Hyun Yoo   +9 more
wiley   +1 more source

Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

Nature Communications, 2018
Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a yet unknown function.
Laura Pascual-Reguant, E. Blanco, Silvia Galan, François le Dily, Yasmina Cuartero, Gemma Serra-Bardenys, V. Di Carlo, Ane Iturbide, Joan Pau Cebrià-Costa, L. Nonell, A. G. de Herreros, L. Di Croce, M. Martí-Renom, S. Peiró   +13 more
semanticscholar   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm. [PDF]

, 1988
L. Loewinger, Frank McKeon
openalex   +1 more source

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

Nucleic Acids Research, 2018
Lamins are the main components of the nucleoskeleton. Whereas their 3D organization was recently described using cryoelectron tomography, no structural data highlights how they interact with their partners at the interface between the inner nuclear ...
C. Samson, Ambre Petitalot, Florian Celli, Isaline Herrada, V. Ropars, Marie-Hélène Le Du, N. Nhiri, E. Jacquet, A. Arteni, B. Buendia, S. Zinn-Justin   +10 more
semanticscholar   +1 more source

Lamins for differentiation [PDF]

The Journal of Cell Biology, 2006
![Graphic][1] Excess lamins delay the cell cycle.On page [83][2], Dorner et al. report that overexpression of a lamina-associated protein slows cell proliferation and promotes differentiation in vitro.
openaire   +2 more sources