Results 111 to 120 of about 92,845 (317)

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Lysosome-mediated processing of chromatin in senescence [PDF]

, 2013
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are
Adams, Adams-Cioaba, Andre Ivanov, Barnhill, Barradas, Bodnar, Braig, Bridger, Butin-Israeli, Cao, Chen, Chen, Coffinier, Collado, Cosme-Blanco, Dang, David M. Nelson, De Cecco, De Cecco, De Vos, Demidenko, Di Micco, Duncan, Feldser, Feser, Fraga, Freund, Funayama, Glatz, Goldman, Graeme Hewitt, Gray-Schopfer, Gray-Schopfer, Greer, Hayflick, Hong Wu, Houben, Howard, Hunt, Ichijima, Iglesias-Bartolome, Imai, Indrani Manoharan, Ishidoh, Jeff Pawlikowski, Joao F. Passos, John van Tuyn, Kanfi, Kang, Kennedy, Klionsky, Kreiling, Krizhanovsky, Krtolica, Kuilman, Lamark, Laszlo, Lee, Maures, McManus, Michaloglou, Michishita, Narita, Narita, Narita, Omholt, O’Sullivan, Pankiv, Parisha P. Shah, Passos, Peleg, Peter D. Adams, Pollock, Pospelova, Ruhoy, Sagiv, Santos-Rosa, Scaffidi, Serrano, Shelley L. Berger, Shimi, Shimi, Siebold, Smolle, Smolle, Soutoglou, Suram, Taranjit Singh Rai, Tran, Vargas, Vergnes, Viktor I. Korolchuk, Villeponteau, Wang, Wood, Xue, Yang, Young, Zhang, Zhang, Ziegler-Birling   +100 more
core   +2 more sources

Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage

Journal of experimental & clinical cancer research : CR, 2019
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components.
Yu-Nong Li, Xiu-xing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiao-ye Hu, Lirong Li, Jingshan Shi, N. Gao   +9 more
semanticscholar   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Lamin A/C promotes DNA base excision repair.

Nucleic Acids Research, 2019
The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature aging disease Hutchinson-Gilford progeria ...
Scott Maynard, Guido Keijzers, Mansour Akbari, M. B. Ezra, Arnaldur Hall, M. Morevati, M. Scheibye-Knudsen, S. Gonzalo, J. Bartek, V. Bohr   +9 more
semanticscholar   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

Nature Communications, 2019
The nuclear lamina—a meshwork of intermediate filaments termed lamins—is primarily responsible for the mechanical stability of the nucleus in multicellular organisms.
K. Sapra, Zhao Qin, Anna Dubrovsky-Gaupp, U. Aebi, D. Müller, M. Buehler, O. Medalia   +6 more
semanticscholar   +1 more source

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]

, 2004
Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Bridger, JM, Kill, IR
core   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Anti-lamin A/C antibodies in patients with Behçet’s disease

Central European Journal of Immunology, 2018
Lamin A/C has been identified as a target antigen of anti-endothelial cell antibodies in vasculitis. Behçet’s disease (BD) is a chronic vasculitis with unclear pathogenesis.
Peng Chen, Hai Yan, Wen Zhang, Chunhe Yang, Hongwu Du   +4 more
doaj   +1 more source